| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 3,240,086 | 3,458,863 | +218,777 | 0.43 | 0.53 | +0.10 | buy |
| Orbis Allan Gray Ltd | 1,255,162 | 2,472,480 | +1,217,318 | 1.55 | 3.36 | +1.81 | buy |
| BlackRock, Inc. | 2,078,500 | 2,324,929 | +246,429 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 1,358,675 | 2,160,943 | +802,268 | 0.02 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,995,986 | 2,035,986 | +40,000 | 10.78 | 12.96 | +2.18 | buy |
| BAKER BROS. ADVISORS LP | 1,126,488 | 1,753,198 | +626,710 | 1.94 | 3.24 | +1.30 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 903,351 | 963,351 | +60,000 | 3.41 | 3.66 | +0.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,061 | 949,225 | +16,164 | 1.87 | 2.25 | +0.38 | buy |
| Cormorant Asset Management, LP | 950,000 | 885,500 | -64,500 | 15.87 | 14.38 | -1.49 | sell |
| STATE STREET CORP | 882,215 | 884,238 | +2,023 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 889,889 | 833,491 | -56,398 | 0.02 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 965,313 | 815,739 | -149,574 | 0.43 | 0.41 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 716,184 | 710,734 | -5,450 | 0.03 | 0.03 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 562,379 | 650,904 | +88,525 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 785,987 | 630,852 | -155,135 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 522,763 | 534,604 | +11,841 | 0.01 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 373,787 | 373,787 | 0 | 1.13 | 1.28 | +0.15 | hold |
| Hood River Capital Management LLC | 289,467 | 358,618 | +69,151 | 0.94 | 1.16 | +0.22 | buy |
| Vivo Capital, LLC | 328,895 | 338,895 | +10,000 | 6.27 | 9.08 | +2.81 | buy |
| Soleus Capital Management, L.P. | 362,966 | 330,517 | -32,449 | 4.54 | 4.31 | -0.23 | sell |
| Pictet Asset Management Holding SA | 240,588 | 286,644 | +46,056 | 0.07 | 0.10 | +0.03 | buy |
| Logos Global Management LP | 375,000 | 285,000 | -90,000 | 7.37 | 4.73 | -2.64 | sell |
| FRANKLIN RESOURCES INC | 356,074 | 276,123 | -79,951 | 0.03 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 192,284 | 227,934 | +35,650 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,301 | 215,447 | +17,146 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 105,412 | 200,013 | +94,601 | 0.12 | 0.24 | +0.12 | buy |
| T. Rowe Price Investment Management, Inc. | 276,392 | 175,237 | -101,155 | 0.05 | 0.04 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 176,562 | 174,350 | -2,212 | 0.01 | 0.01 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 94,500 | 172,500 | +78,000 | 0.57 | 1.21 | +0.64 | buy |
| Aberdeen Group plc | 134,992 | 172,484 | +37,492 | 0.06 | 0.09 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 185,000 | 170,000 | -15,000 | 3.92 | 3.21 | -0.71 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,626 | 143,082 | +138,456 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,366 | 128,254 | +52,888 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 168,897 | 128,228 | -40,669 | 0.07 | 0.06 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 30,000 | 117,851 | +87,851 | 0.19 | 1.01 | +0.81 | buy |
| UBS Group AG | 89,200 | 108,446 | +19,246 | 0.01 | 0.01 | +0.00 | buy |
| Velan Capital Investment Management LP | 100,781 | 100,781 | 0 | 17.28 | 20.34 | +3.06 | hold |
| Bank of New York Mellon Corp | 77,897 | 87,047 | +9,150 | 0.00 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 83,036 | 84,901 | +1,865 | 16.62 | 19.46 | +2.84 | buy |
| MetLife Investment Management, LLC | 12,424 | 80,930 | +68,506 | 0.02 | 0.13 | +0.12 | buy |
| JPMORGAN CHASE & CO | 55,300 | 80,180 | +24,880 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 74,376 | 72,178 | -2,198 | 0.06 | 0.07 | +0.00 | sell |
| Nuveen, LLC | 49,970 | 72,043 | +22,073 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 86,581 | 71,581 | -15,000 | 3.30 | 3.30 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 82,465 | 71,552 | -10,913 | 3.52 | 2.72 | -0.80 | sell |
| Ensign Peak Advisors, Inc | 64,283 | 68,383 | +4,100 | 0.03 | 0.04 | +0.01 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 38.42 | 42.83 | +4.40 | hold |
| Sofinnova Investments, Inc. | 125,722 | 63,680 | -62,042 | 1.60 | 1.03 | -0.57 | sell |
| Candriam S.C.A. | 110,590 | 63,628 | -46,962 | 0.16 | 0.11 | -0.06 | sell |
| Invesco Ltd. | 77,088 | 61,397 | -15,691 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 28,828 | 58,656 | +29,828 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 50,811 | 57,779 | +6,968 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 21,067 | 56,267 | +35,200 | 1.07 | 3.48 | +2.42 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 53,365 | +53,365 | 0.00 | 0.18 | +0.18 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,377 | 47,432 | +10,055 | 0.02 | 0.03 | +0.01 | buy |
| Swiss National Bank | 40,500 | 46,700 | +6,200 | 0.01 | 0.01 | +0.00 | buy |
| Boxer Capital Management, LLC | 46,457 | 46,457 | 0 | 3.00 | 1.97 | -1.03 | hold |
| Exome Asset Management LLC | 58,122 | 45,469 | -12,653 | 8.46 | 8.62 | +0.16 | sell |
| MARSHALL WACE, LLP | 69,242 | 45,149 | -24,093 | 0.02 | 0.02 | -0.00 | sell |
| First Turn Management, LLC | 35,749 | 42,441 | +6,692 | 1.20 | 1.53 | +0.32 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 42,163 | +42,163 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 69,712 | 40,130 | -29,582 | 0.01 | 0.01 | -0.01 | sell |
| Integral Health Asset Management, LLC | 40,000 | 40,000 | 0 | 0.60 | 0.68 | +0.08 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 67,100 | 38,640 | -28,460 | 0.31 | 0.21 | -0.10 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,288 | 38,145 | +2,857 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 41,629 | 36,838 | -4,791 | 0.37 | 0.38 | +0.01 | sell |
| PFM Health Sciences, LP | 31,163 | 35,438 | +4,275 | 0.93 | 1.20 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 46,146 | 35,146 | -11,000 | 0.01 | 0.01 | -0.00 | sell |
| Burkehill Global Management, LP | 25,000 | 35,000 | +10,000 | 0.49 | 0.56 | +0.07 | buy |
| FIRST TRUST ADVISORS LP | 88,704 | 33,335 | -55,369 | 0.02 | 0.01 | -0.01 | sell |
| B Group, Inc. | 33,237 | 33,237 | 0 | 7.26 | 7.94 | +0.68 | hold |
| RHUMBLINE ADVISERS | 28,324 | 32,879 | +4,555 | 0.01 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 19,882 | 32,810 | +12,928 | 9.30 | 10.50 | +1.20 | buy |
| AMERIPRISE FINANCIAL INC | 22,715 | 31,220 | +8,505 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,543 | 31,161 | +7,618 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 14,862 | 30,510 | +15,648 | 0.01 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,291 | 30,093 | -3,198 | 0.01 | 0.01 | +0.00 | sell |
| LORD, ABBETT & CO. LLC | 30,756 | 29,619 | -1,137 | 0.03 | 0.03 | +0.00 | sell |
| SEI INVESTMENTS CO | 15,796 | 29,525 | +13,729 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,655 | 28,134 | +14,479 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,559 | 27,744 | +2,185 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 25,070 | 27,700 | +2,630 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,671 | 27,477 | +7,806 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 25,841 | 26,323 | +482 | 1.96 | 2.34 | +0.38 | buy |
| Neuberger Berman Group LLC | 25,678 | 25,960 | +282 | 0.01 | 0.01 | +0.00 | buy |
| University of Wisconsin Foundation | 0 | 25,215 | +25,215 | 0.00 | 7.21 | +7.21 | buy |
| CONGRESS ASSET MANAGEMENT CO | 31,246 | 24,839 | -6,407 | 0.06 | 0.06 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 23,251 | 23,251 | 0 | 0.11 | 0.11 | +0.01 | hold |
| Russell Investments Group, Ltd. | 20,612 | 23,112 | +2,500 | 0.01 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 41,731 | 21,688 | -20,043 | 2.30 | 1.26 | -1.04 | sell |
| Atom Investors LP | 16,487 | 21,196 | +4,709 | 0.39 | 0.49 | +0.10 | buy |
| Informed Momentum Co LLC | 20,941 | 18,995 | -1,946 | 0.69 | 0.71 | +0.02 | sell |
| Legal & General Group Plc | 17,981 | 18,482 | +501 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 23,098 | 17,598 | -5,500 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,974 | 17,587 | -3,387 | 0.16 | 0.13 | -0.03 | sell |
| Creative Planning | 10,843 | 16,286 | +5,443 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 80,640 | 16,168 | -64,472 | 0.37 | 0.08 | -0.29 | sell |
| TFG Asset Management GP Ltd | 22,952 | 15,952 | -7,000 | 1.43 | 1.01 | -0.42 | sell |
| J. Goldman & Co LP | 5,550 | 15,664 | +10,114 | 0.06 | 0.23 | +0.17 | buy |
| Rafferty Asset Management, LLC | 22,240 | 15,188 | -7,052 | 0.02 | 0.02 | -0.00 | sell |