| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Orbis Allan Gray Ltd | 1,255,162 | 2,472,480 | +1,217,318 | 1.55 | 3.36 | +1.81 | buy |
| FMR LLC | 1,358,675 | 2,160,943 | +802,268 | 0.02 | 0.04 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 1,126,488 | 1,753,198 | +626,710 | 1.94 | 3.24 | +1.30 | buy |
| BlackRock, Inc. | 2,078,500 | 2,324,929 | +246,429 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,240,086 | 3,458,863 | +218,777 | 0.43 | 0.53 | +0.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,626 | 143,082 | +138,456 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 105,412 | 200,013 | +94,601 | 0.12 | 0.24 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 562,379 | 650,904 | +88,525 | 0.01 | 0.01 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 30,000 | 117,851 | +87,851 | 0.19 | 1.01 | +0.81 | buy |
| ORBIMED ADVISORS LLC | 94,500 | 172,500 | +78,000 | 0.57 | 1.21 | +0.64 | buy |
| Hood River Capital Management LLC | 289,467 | 358,618 | +69,151 | 0.94 | 1.16 | +0.22 | buy |
| MetLife Investment Management, LLC | 12,424 | 80,930 | +68,506 | 0.02 | 0.13 | +0.12 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 903,351 | 963,351 | +60,000 | 3.41 | 3.66 | +0.25 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 53,365 | +53,365 | 0.00 | 0.18 | +0.18 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,366 | 128,254 | +52,888 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 240,588 | 286,644 | +46,056 | 0.07 | 0.10 | +0.03 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 42,163 | +42,163 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,995,986 | 2,035,986 | +40,000 | 10.78 | 12.96 | +2.18 | buy |
| Aberdeen Group plc | 134,992 | 172,484 | +37,492 | 0.06 | 0.09 | +0.03 | buy |
| NORTHERN TRUST CORP | 192,284 | 227,934 | +35,650 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 21,067 | 56,267 | +35,200 | 1.07 | 3.48 | +2.42 | buy |
| AQR CAPITAL MANAGEMENT LLC | 28,828 | 58,656 | +29,828 | 0.00 | 0.01 | +0.00 | buy |
| University of Wisconsin Foundation | 0 | 25,215 | +25,215 | 0.00 | 7.21 | +7.21 | buy |
| JPMORGAN CHASE & CO | 55,300 | 80,180 | +24,880 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 49,970 | 72,043 | +22,073 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 89,200 | 108,446 | +19,246 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,301 | 215,447 | +17,146 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 933,061 | 949,225 | +16,164 | 1.87 | 2.25 | +0.38 | buy |
| PRUDENTIAL FINANCIAL INC | 14,862 | 30,510 | +15,648 | 0.01 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,742 | +14,742 | 0.00 | 0.05 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,655 | 28,134 | +14,479 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 15,796 | 29,525 | +13,729 | 0.00 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 19,882 | 32,810 | +12,928 | 9.30 | 10.50 | +1.20 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 12,473 | +12,473 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 522,763 | 534,604 | +11,841 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 2,400 | 14,030 | +11,630 | 0.00 | 0.01 | +0.00 | buy |
| J. Goldman & Co LP | 5,550 | 15,664 | +10,114 | 0.06 | 0.23 | +0.17 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,377 | 47,432 | +10,055 | 0.02 | 0.03 | +0.01 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 10,043 | +10,043 | 0.00 | 0.02 | +0.02 | buy |
| Vivo Capital, LLC | 328,895 | 338,895 | +10,000 | 6.27 | 9.08 | +2.81 | buy |
| Burkehill Global Management, LP | 25,000 | 35,000 | +10,000 | 0.49 | 0.56 | +0.07 | buy |
| BRAIDWELL LP | 0 | 9,976 | +9,976 | 0.00 | 0.11 | +0.11 | buy |
| Bank of New York Mellon Corp | 77,897 | 87,047 | +9,150 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 22,715 | 31,220 | +8,505 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,671 | 27,477 | +7,806 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,543 | 31,161 | +7,618 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 50,811 | 57,779 | +6,968 | 0.00 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 1,732 | 8,536 | +6,804 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 35,749 | 42,441 | +6,692 | 1.20 | 1.53 | +0.32 | buy |
| Swiss National Bank | 40,500 | 46,700 | +6,200 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,343 | 8,517 | +6,174 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,843 | 16,286 | +5,443 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 5,000 | +5,000 | 0.00 | 0.04 | +0.04 | buy |
| Atom Investors LP | 16,487 | 21,196 | +4,709 | 0.39 | 0.49 | +0.10 | buy |
| RHUMBLINE ADVISERS | 28,324 | 32,879 | +4,555 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 552 | 5,060 | +4,508 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 31,163 | 35,438 | +4,275 | 0.93 | 1.20 | +0.27 | buy |
| Ensign Peak Advisors, Inc | 64,283 | 68,383 | +4,100 | 0.03 | 0.04 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 3,316 | 7,388 | +4,072 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 98 | 4,049 | +3,951 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 3,948 | +3,948 | 0.00 | 0.09 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 3,831 | +3,831 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 3,589 | +3,589 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 3,512 | +3,512 | 0.00 | 0.01 | +0.01 | buy |
| FORA Capital, LLC | 0 | 3,412 | +3,412 | 0.00 | 0.08 | +0.08 | buy |
| HOMESTEAD ADVISERS CORP | 0 | 3,300 | +3,300 | 0.00 | 0.03 | +0.03 | buy |
| LPL Financial LLC | 0 | 2,923 | +2,923 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,288 | 38,145 | +2,857 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 2,670 | +2,670 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 25,070 | 27,700 | +2,630 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 20,612 | 23,112 | +2,500 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,559 | 27,744 | +2,185 | 0.01 | 0.01 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 4,505 | 6,681 | +2,176 | 0.02 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 882,215 | 884,238 | +2,023 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 1,956 | +1,956 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 83,036 | 84,901 | +1,865 | 16.62 | 19.46 | +2.84 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 2,082 | 3,855 | +1,773 | 0.09 | 1.81 | +1.72 | buy |
| Bellevue Group AG | 0 | 1,757 | +1,757 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,660 | +1,660 | 0.00 | 0.02 | +0.02 | buy |
| Hudson Bay Capital Management LP | 0 | 1,640 | +1,640 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 1,501 | +1,501 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | 8,749 | +1,449 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 1,393 | +1,393 | 0.00 | 0.07 | +0.07 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 1,344 | +1,344 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 1,344 | +1,344 | 0.00 | 0.01 | +0.01 | buy |
| Integrated Quantitative Investments LLC | 0 | 1,253 | +1,253 | 0.00 | 0.07 | +0.07 | buy |
| Fieldview Capital Management, LLC | 0 | 1,223 | +1,223 | 0.00 | 0.12 | +0.12 | buy |
| Mariner, LLC | 0 | 1,177 | +1,177 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 1,146 | +1,146 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 0 | 1,060 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 7,018 | 8,058 | +1,040 | 0.01 | 0.01 | +0.00 | buy |
| Amundi | 790 | 1,802 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| Gallagher Fiduciary Advisors, LLC | 0 | 990 | +990 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 972 | +972 | 0.00 | 0.00 | +0.00 | buy |
| Brick & Kyle, Associates | 0 | 966 | +966 | 0.00 | 0.10 | +0.10 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,057 | 6,989 | +932 | 0.01 | 0.02 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 925 | +925 | 0.00 | 0.68 | +0.68 | buy |
| Daiwa Securities Group Inc. | 72 | 946 | +874 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 837 | +837 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 13,298 | 14,132 | +834 | 0.00 | 0.00 | +0.00 | buy |