| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 44,508 | 819,142 | +774,634 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 37,268 | 533,015 | +495,747 | 0.20 | 1.94 | +1.74 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 828,380 | 1,235,599 | +407,219 | 0.64 | 0.68 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 535,999 | 938,579 | +402,580 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 389,546 | +389,546 | 0.00 | 0.48 | +0.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 134,717 | 395,059 | +260,342 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 744,069 | 977,145 | +233,076 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 210,000 | 440,000 | +230,000 | 1.06 | 1.36 | +0.30 | buy |
| Verition Fund Management LLC | 545,408 | 748,320 | +202,912 | 0.32 | 0.24 | -0.08 | buy |
| MARSHALL WACE, LLP | 121,024 | 248,381 | +127,357 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 177,139 | 283,424 | +106,285 | 1.75 | 1.91 | +0.16 | buy |
| Point72 Asset Management, L.P. | 954,140 | 1,051,701 | +97,561 | 0.17 | 0.14 | -0.03 | buy |
| FRANKLIN RESOURCES INC | 145,295 | 239,898 | +94,603 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 100,136 | 184,319 | +84,183 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 310,059 | 381,685 | +71,626 | 0.01 | 0.01 | -0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 350,000 | 415,000 | +65,000 | 2.83 | 2.65 | -0.18 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 12,104 | 75,433 | +63,329 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 49,510 | +49,510 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 41,358 | +41,358 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 6,689 | 47,474 | +40,785 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 98,635 | 130,997 | +32,362 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 0 | 32,000 | +32,000 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 5,000 | 32,005 | +27,005 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 26,777 | +26,777 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 24,381 | +24,381 | 0.00 | 0.20 | +0.20 | buy |
| RHUMBLINE ADVISERS | 152 | 22,192 | +22,040 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 21,882 | +21,882 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 21,077 | +21,077 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 21,000 | +21,000 | 0.00 | 0.24 | +0.24 | buy |
| NORTHERN TRUST CORP | 27,279 | 48,069 | +20,790 | 0.00 | 0.00 | +0.00 | buy |
| Ovata Capital Management Ltd | 20,000 | 40,000 | +20,000 | 0.64 | 0.90 | +0.26 | buy |
| BANK OF AMERICA CORP /DE/ | 19,004 | 38,554 | +19,550 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 4,343 | 22,807 | +18,464 | 0.01 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 18,040 | +18,040 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 16,328 | +16,328 | 0.00 | 0.12 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 35,000 | 51,312 | +16,312 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 15,945 | +15,945 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,865 | 35,308 | +15,443 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 14,041 | +14,041 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 13,342 | +13,342 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 11,950 | +11,950 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 39,565 | 51,513 | +11,948 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 51,548 | 63,361 | +11,813 | 0.01 | 0.01 | -0.00 | buy |
| Ballentine Partners, LLC | 0 | 10,911 | +10,911 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 3,449 | 14,321 | +10,872 | 0.01 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 4,244 | 12,659 | +8,415 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 152 | 7,909 | +7,757 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 7,686 | +7,686 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 27,667 | 35,223 | +7,556 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 6,406 | 13,348 | +6,942 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 6,765 | +6,765 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 6,270 | +6,270 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 5,824 | +5,824 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 654 | 6,077 | +5,423 | 0.00 | 0.00 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 12,917 | 17,441 | +4,524 | 0.37 | 0.31 | -0.06 | buy |
| MetLife Investment Management, LLC | 0 | 4,423 | +4,423 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 26,893 | 29,259 | +2,366 | 0.44 | 0.36 | -0.08 | buy |
| VIRTUS ADVISERS, LLC | 0 | 2,260 | +2,260 | 0.00 | 0.05 | +0.05 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 162,302 | 164,431 | +2,129 | 6.43 | 5.73 | -0.70 | buy |
| Russell Investments Group, Ltd. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,000 | +2,000 | 0.00 | 0.03 | +0.03 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,689 | +1,689 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,684 | +1,684 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 1,105 | +1,105 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 34,729 | 35,729 | +1,000 | 0.06 | 0.04 | -0.02 | buy |
| AMALGAMATED BANK | 0 | 597 | +597 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 23,372 | 23,966 | +594 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Asset Management Inc | 192,304 | 192,667 | +363 | 0.04 | 0.03 | -0.01 | buy |
| Pacer Advisors, Inc. | 0 | 235 | +235 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 706,126 | 706,131 | +5 | 2.05 | 1.86 | -0.19 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 131,533 | 131,533 | 0 | 0.10 | 0.07 | -0.03 | hold |
| Aberdeen Group plc | 4,999 | 4,999 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 340,000 | 340,000 | 0 | 4.65 | 3.15 | -1.50 | hold |
| Windmill Hill Asset Management Ltd | 5,268 | 5,268 | 0 | 0.12 | 0.09 | -0.02 | hold |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 6.00 | 6.85 | +0.86 | hold |
| Octagon Capital Advisors LP | 260,000 | 260,000 | 0 | 1.93 | 1.77 | -0.15 | hold |
| Velan Capital Investment Management LP | 350,666 | 350,666 | 0 | 11.57 | 8.31 | -3.26 | hold |
| BARCLAYS PLC | 16,445 | 16,371 | -74 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 109 | 0 | -109 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,848 | 1,519 | -329 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 966 | 0 | -966 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,355 | 1,561 | -1,794 | 0.01 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 266,496 | 264,688 | -1,808 | 0.16 | 0.11 | -0.06 | sell |
| SG Americas Securities, LLC | 2,465 | 0 | -2,465 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 26,008 | 22,646 | -3,362 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 3,726 | 0 | -3,726 | 0.06 | 0.00 | -0.06 | sell |
| CHASE INVESTMENT COUNSEL CORP | 3,768 | 0 | -3,768 | 0.09 | 0.00 | -0.09 | sell |
| Coastal Bridge Advisors, LLC | 3,846 | 0 | -3,846 | 0.05 | 0.00 | -0.05 | sell |
| Schonfeld Strategic Advisors LLC | 4,028 | 0 | -4,028 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 4,261 | 0 | -4,261 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,750 | 2,029 | -4,721 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 5,627 | 0 | -5,627 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 159,486 | 153,379 | -6,107 | 5.41 | 3.78 | -1.63 | sell |
| CITIGROUP INC | 15,118 | 7,611 | -7,507 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 7,612 | 0 | -7,612 | 0.00 | 0.00 | -0.00 | sell |