| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 37,268 | 533,015 | +495,747 | 0.20 | 1.94 | +1.74 | buy |
| Vestal Point Capital, LP | 210,000 | 440,000 | +230,000 | 1.06 | 1.36 | +0.30 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 177,139 | 283,424 | +106,285 | 1.52 | 1.60 | +0.08 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 350,000 | 415,000 | +65,000 | 2.83 | 2.65 | -0.18 | buy |
| Ovata Capital Management Ltd | 20,000 | 40,000 | +20,000 | 0.64 | 0.90 | +0.26 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 51,548 | 63,361 | +11,813 | 0.01 | 0.01 | -0.00 | buy |
| PCG Wealth Advisors, LLC | 12,917 | 17,441 | +4,524 | 0.37 | 0.31 | -0.06 | buy |
| STEMPOINT CAPITAL LP | 26,893 | 29,259 | +2,366 | 0.44 | 0.36 | -0.08 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 162,302 | 164,431 | +2,129 | 6.43 | 5.73 | -0.71 | buy |
| VR Adviser, LLC | 706,126 | 706,131 | +5 | 2.05 | 1.86 | -0.19 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 266,496 | 264,688 | -1,808 | 0.16 | 0.11 | -0.06 | sell |
| Ally Bridge Group (NY) LLC | 159,486 | 153,379 | -6,107 | 5.41 | 3.78 | -1.63 | sell |
| PFM Health Sciences, LP | 477,605 | 453,146 | -24,459 | 1.37 | 0.93 | -0.44 | sell |
| Tri Locum Partners LP | 106,494 | 75,319 | -31,175 | 2.25 | 0.79 | -1.47 | sell |
| FRED ALGER MANAGEMENT, LLC | 47,041 | 2,595 | -44,446 | 0.01 | 0.00 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 821,589 | 750,230 | -71,359 | 0.88 | 0.75 | -0.13 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 190,556 | 67,296 | -123,260 | 3.26 | 0.69 | -2.57 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,393,028 | 1,134,083 | -258,945 | 0.16 | 0.09 | -0.07 | sell |
| Cormorant Asset Management, LP | 1,310,000 | 685,000 | -625,000 | 3.51 | 1.64 | -1.87 | sell |