| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 331,533 | 689,488 | +357,955 | 0.14 | 0.28 | +0.14 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,742,758 | 1,974,585 | +231,827 | 0.12 | 0.14 | +0.02 | buy |
| Ikarian Capital, LLC | 145,502 | 276,950 | +131,448 | 0.68 | 2.24 | +1.56 | buy |
| Aberdeen Group plc | 87,903 | 214,056 | +126,153 | 0.01 | 0.02 | +0.01 | buy |
| Tri Locum Partners LP | 83,659 | 195,432 | +111,773 | 1.63 | 2.49 | +0.87 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 619,931 | 686,931 | +67,000 | 0.46 | 0.52 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 481,598 | 530,988 | +49,390 | 0.18 | 0.18 | +0.00 | buy |
| HighVista Strategies LLC | 39,286 | 67,288 | +28,002 | 0.57 | 1.04 | +0.47 | buy |
| B Group, Inc. | 19,000 | 35,000 | +16,000 | 0.63 | 1.27 | +0.65 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 65,265 | 70,445 | +5,180 | 0.06 | 0.07 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 4,044 | 4,091 | +47 | 0.01 | 0.02 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 2,316 | 2,088 | -228 | 0.02 | 0.03 | +0.01 | sell |
| PROFUND ADVISORS LLC | 6,108 | 5,261 | -847 | 0.01 | 0.01 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 87,141 | 74,087 | -13,054 | 3.83 | 4.35 | +0.52 | sell |
| Ally Bridge Group (NY) LLC | 95,582 | 80,880 | -14,702 | 3.26 | 2.83 | -0.43 | sell |
| Alyeska Investment Group, L.P. | 150,000 | 125,000 | -25,000 | 0.02 | 0.02 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 140,660 | 109,757 | -30,903 | 1.23 | 1.08 | -0.14 | sell |
| Velan Capital Investment Management LP | 185,000 | 149,334 | -35,666 | 7.21 | 6.28 | -0.92 | sell |
| PFM Health Sciences, LP | 160,866 | 84,713 | -76,153 | 0.44 | 0.30 | -0.14 | sell |
| Cormorant Asset Management, LP | 1,745,000 | 1,625,000 | -120,000 | 4.97 | 5.09 | +0.12 | sell |
| Woodline Partners LP | 175,727 | 45,952 | -129,775 | 0.04 | 0.01 | -0.03 | sell |
| Sofinnova Investments, Inc. | 157,640 | 15,717 | -141,923 | 0.39 | 0.04 | -0.35 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 166,074 | 10,000 | -156,074 | 1.31 | 0.09 | -1.23 | sell |
| Soleus Capital Management, L.P. | 1,139,740 | 966,740 | -173,000 | 3.38 | 2.81 | -0.58 | sell |
| PERCEPTIVE ADVISORS LLC | 980,894 | 752,921 | -227,973 | 1.31 | 1.17 | -0.14 | sell |