| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,506,436 | 2,533,405 | +1,026,969 | 0.03 | 0.05 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,742,758 | 1,974,585 | +231,827 | 0.12 | 0.14 | +0.02 | buy |
| Cormorant Asset Management, LP | 1,745,000 | 1,625,000 | -120,000 | 5.00 | 5.09 | +0.09 | sell |
| BlackRock, Inc. | 1,416,935 | 1,590,128 | +173,193 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,095,725 | 1,473,075 | +377,350 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,213,669 | 1,226,339 | +12,670 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,087,020 | 1,215,644 | +128,624 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,139,740 | 966,740 | -173,000 | 3.38 | 2.81 | -0.58 | sell |
| Point72 Asset Management, L.P. | 333,534 | 954,075 | +620,541 | 0.04 | 0.09 | +0.06 | buy |
| PERCEPTIVE ADVISORS LLC | 980,894 | 752,921 | -227,973 | 1.32 | 1.19 | -0.13 | sell |
| STATE STREET CORP | 737,039 | 698,093 | -38,946 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 331,533 | 689,488 | +357,955 | 0.14 | 0.28 | +0.14 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 619,931 | 686,931 | +67,000 | 0.47 | 0.52 | +0.06 | buy |
| Assenagon Asset Management S.A. | 507,400 | 604,298 | +96,898 | 0.03 | 0.04 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 481,598 | 530,988 | +49,390 | 0.18 | 0.18 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 460,707 | 453,403 | -7,304 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 418,016 | 451,731 | +33,715 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 388,759 | 388,759 | 0 | 0.05 | 0.05 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 403,003 | 369,254 | -33,749 | 0.04 | 0.04 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 314,127 | 314,150 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 145,502 | 276,950 | +131,448 | 1.80 | 3.85 | +2.06 | buy |
| GOLDMAN SACHS GROUP INC | 177,264 | 225,992 | +48,728 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 225,000 | +225,000 | 0.00 | 1.26 | +1.26 | buy |
| Aberdeen Group plc | 87,903 | 214,056 | +126,153 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 165,183 | 213,712 | +48,529 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 83,659 | 195,432 | +111,773 | 1.63 | 2.49 | +0.87 | buy |
| 5AM Venture Management, LLC | 170,000 | 170,000 | 0 | 2.43 | 2.75 | +0.31 | hold |
| Vivo Capital, LLC | 0 | 167,600 | +167,600 | 0.00 | 0.72 | +0.72 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 141,080 | 152,444 | +11,364 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 185,000 | 149,334 | -35,666 | 7.21 | 6.28 | -0.92 | sell |
| Alyeska Investment Group, L.P. | 150,000 | 125,000 | -25,000 | 0.02 | 0.02 | -0.00 | sell |
| Verition Fund Management LLC | 199,657 | 118,482 | -81,175 | 0.04 | 0.03 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 46,626 | 118,121 | +71,495 | 0.06 | 0.15 | +0.09 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 140,660 | 109,757 | -30,903 | 1.31 | 1.21 | -0.11 | sell |
| Schonfeld Strategic Advisors LLC | 6,074 | 100,702 | +94,628 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,081 | 96,945 | +9,864 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 31,768 | 88,724 | +56,956 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 192,909 | 86,534 | -106,375 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 160,866 | 84,713 | -76,153 | 0.47 | 0.31 | -0.16 | sell |
| Ally Bridge Group (NY) LLC | 95,582 | 80,880 | -14,702 | 3.26 | 2.83 | -0.43 | sell |
| Pictet Asset Management Holding SA | 78,588 | 79,143 | +555 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 87,141 | 74,087 | -13,054 | 3.83 | 4.35 | +0.52 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 65,265 | 70,445 | +5,180 | 0.06 | 0.07 | +0.01 | buy |
| HighVista Strategies LLC | 39,286 | 67,288 | +28,002 | 0.57 | 1.04 | +0.47 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 7.02 | 7.23 | +0.22 | hold |
| TD ASSET MANAGEMENT INC | 37,138 | 63,938 | +26,800 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 63,671 | 63,671 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Exome Asset Management LLC | 0 | 59,002 | +59,002 | 0.00 | 2.05 | +2.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,492 | 56,131 | +23,639 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 50,776 | 55,881 | +5,105 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 46,307 | 52,553 | +6,246 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,748 | 46,927 | +12,179 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 175,727 | 45,952 | -129,775 | 0.04 | 0.01 | -0.03 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,999 | 45,082 | +5,083 | 0.01 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 18,280 | 39,036 | +20,756 | 0.03 | 0.15 | +0.12 | buy |
| Nuveen, LLC | 5,611 | 38,549 | +32,938 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 35,719 | 38,100 | +2,381 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 19,000 | 35,000 | +16,000 | 0.63 | 1.27 | +0.65 | buy |
| STEMPOINT CAPITAL LP | 0 | 32,255 | +32,255 | 0.00 | 0.44 | +0.44 | buy |
| Swiss National Bank | 27,100 | 30,800 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 21,490 | 27,570 | +6,080 | 0.02 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 24,294 | 27,341 | +3,047 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 3,298 | 25,328 | +22,030 | 0.00 | 0.03 | +0.02 | buy |
| Rafferty Asset Management, LLC | 29,245 | 24,805 | -4,440 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 24,292 | +24,292 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,708 | 23,873 | +12,165 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 22,593 | +22,593 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,793 | 21,892 | -4,901 | 0.02 | 0.03 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 19,900 | +19,900 | 0.00 | 0.08 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 12,208 | 19,056 | +6,848 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 51,116 | 18,040 | -33,076 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 14,409 | 16,670 | +2,261 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,346 | 16,346 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 11,678 | 15,939 | +4,261 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 157,640 | 15,717 | -141,923 | 0.45 | 0.04 | -0.41 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,611 | 14,759 | +148 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 11,479 | 13,938 | +2,459 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 9,489 | 13,003 | +3,514 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,861 | 12,124 | -1,737 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 12,977 | 12,008 | -969 | 0.04 | 0.04 | -0.01 | sell |
| CITIGROUP INC | 45,632 | 11,866 | -33,766 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 8,517 | 11,252 | +2,735 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 14,938 | 10,994 | -3,944 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 10,597 | 10,520 | -77 | 0.00 | 0.00 | +0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 10,500 | 10,500 | 0 | 0.10 | 0.10 | +0.00 | hold |
| CITADEL ADVISORS LLC | 62,210 | 10,366 | -51,844 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 166,074 | 10,000 | -156,074 | 1.31 | 0.09 | -1.23 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 8,798 | 8,719 | -79 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 8,503 | +8,503 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,600 | 6,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 18,808 | 6,509 | -12,299 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 0 | 6,495 | +6,495 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,040 | 6,425 | +385 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 5,750 | +5,750 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 5,611 | +5,611 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 6,108 | 5,261 | -847 | 0.01 | 0.01 | -0.00 | sell |
| Virtu Financial LLC | 0 | 5,058 | +5,058 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 84,200 | 5,000 | -79,200 | 0.00 | 0.00 | -0.00 | sell |
| Maven Securities LTD | 0 | 5,000 | +5,000 | 0.00 | 0.05 | +0.05 | buy |