| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,160,943 | 2,316,907 | +155,964 | 0.04 | 0.03 | -0.00 | buy |
| BlackRock, Inc. | 2,324,929 | 2,292,585 | -32,344 | 0.01 | 0.01 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 2,035,986 | 2,035,986 | 0 | 12.96 | 10.58 | -2.37 | hold |
| BAKER BROS. ADVISORS LP | 1,753,198 | 1,753,198 | 0 | 3.24 | 2.94 | -0.30 | hold |
| Orbis Allan Gray Ltd | 2,472,480 | 1,529,788 | -942,692 | 3.36 | 1.76 | -1.60 | sell |
| STATE STREET CORP | 884,238 | 1,026,443 | +142,205 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 815,739 | 1,015,480 | +199,741 | 0.41 | 0.48 | +0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 963,351 | 963,351 | 0 | 3.66 | 3.36 | -0.30 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 949,225 | 959,048 | +9,823 | 2.25 | 1.86 | -0.39 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 630,852 | 942,999 | +312,147 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 833,491 | 854,112 | +20,621 | 0.02 | 0.02 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 650,904 | 748,039 | +97,135 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 885,500 | 640,000 | -245,500 | 14.38 | 10.98 | -3.40 | sell |
| GOLDMAN SACHS GROUP INC | 710,734 | 548,830 | -161,904 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 534,604 | 546,930 | +12,326 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 61,397 | 537,548 | +476,151 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 358,618 | 425,167 | +66,549 | 1.16 | 1.03 | -0.13 | buy |
| NORGES BANK | 0 | 346,969 | +346,969 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 276,123 | 327,124 | +51,001 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 286,644 | 291,689 | +5,045 | 0.10 | 0.09 | -0.00 | buy |
| Polar Capital Holdings Plc | 0 | 279,131 | +279,131 | 0.00 | 0.26 | +0.26 | buy |
| Vivo Capital, LLC | 338,895 | 271,116 | -67,779 | 9.08 | 8.29 | -0.79 | sell |
| Logos Global Management LP | 285,000 | 260,000 | -25,000 | 4.73 | 3.75 | -0.98 | sell |
| NORTHERN TRUST CORP | 227,934 | 240,887 | +12,953 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 128,254 | 237,315 | +109,061 | 0.02 | 0.04 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 172,500 | 230,100 | +57,600 | 1.21 | 1.46 | +0.25 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 220,008 | +220,008 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 215,447 | 220,008 | +4,561 | 0.01 | 0.01 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 662 | 218,898 | +218,236 | 0.00 | 0.24 | +0.24 | buy |
| Woodline Partners LP | 200,013 | 200,013 | 0 | 0.24 | 0.21 | -0.04 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 143,082 | 188,409 | +45,327 | 0.03 | 0.03 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 170,000 | 185,000 | +15,000 | 3.21 | 3.03 | -0.18 | buy |
| Soleus Capital Management, L.P. | 330,517 | 177,517 | -153,000 | 4.31 | 2.05 | -2.26 | sell |
| Aberdeen Group plc | 172,484 | 166,399 | -6,085 | 0.09 | 0.08 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 175,237 | 160,477 | -14,760 | 0.04 | 0.04 | -0.00 | sell |
| Qube Research & Technologies Ltd | 128,228 | 152,475 | +24,247 | 0.06 | 0.06 | -0.00 | buy |
| MARSHALL WACE, LLP | 45,149 | 137,008 | +91,859 | 0.02 | 0.04 | +0.02 | buy |
| UBS Group AG | 108,446 | 131,046 | +22,600 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 174,350 | 125,867 | -48,483 | 0.01 | 0.01 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 28,134 | 122,227 | +94,093 | 0.01 | 0.04 | +0.03 | buy |
| Nuveen, LLC | 72,043 | 108,032 | +35,989 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 7,388 | 107,409 | +100,021 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 80,930 | 90,543 | +9,613 | 0.13 | 0.14 | +0.00 | buy |
| Neuberger Berman Group LLC | 25,960 | 89,468 | +63,508 | 0.01 | 0.02 | +0.01 | buy |
| Velan Capital Investment Management LP | 100,781 | 88,781 | -12,000 | 20.34 | 18.21 | -2.13 | sell |
| Bank of New York Mellon Corp | 87,047 | 85,376 | -1,671 | 0.01 | 0.00 | -0.00 | sell |
| First Turn Management, LLC | 42,441 | 83,528 | +41,087 | 1.53 | 2.99 | +1.46 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 84,901 | 82,796 | -2,105 | 19.46 | 19.32 | -0.14 | sell |
| Alyeska Investment Group, L.P. | 72,178 | 80,846 | +8,668 | 0.07 | 0.07 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,500 | 74,253 | +72,753 | 0.03 | 1.17 | +1.14 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 53,365 | 74,207 | +20,842 | 0.18 | 0.23 | +0.05 | buy |
| Ensign Peak Advisors, Inc | 68,383 | 72,952 | +4,569 | 0.04 | 0.04 | -0.00 | buy |
| Ikarian Capital, LLC | 71,581 | 72,842 | +1,261 | 3.30 | 3.99 | +0.69 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,700 | 71,518 | +43,818 | 0.00 | 0.01 | +0.00 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 42.83 | 44.18 | +1.36 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 71,552 | 65,679 | -5,873 | 2.72 | 2.45 | -0.27 | sell |
| AMERIPRISE FINANCIAL INC | 31,220 | 64,295 | +33,075 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 57,779 | 64,263 | +6,484 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 5,320 | 61,980 | +56,660 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 63,628 | 60,856 | -2,772 | 0.11 | 0.09 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 58,656 | 58,446 | -210 | 0.01 | 0.01 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 56,840 | +56,840 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 23,112 | 50,944 | +27,832 | 0.01 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 47,432 | 48,118 | +686 | 0.03 | 0.02 | -0.00 | buy |
| Boxer Capital Management, LLC | 46,457 | 46,457 | 0 | 1.97 | 1.17 | -0.79 | hold |
| Swiss National Bank | 46,700 | 46,100 | -600 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 117,851 | 46,030 | -71,821 | 1.01 | 0.64 | -0.37 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 42,163 | 45,370 | +3,207 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 80,180 | 44,085 | -36,095 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 2,010 | 42,501 | +40,491 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 29,525 | 40,117 | +10,592 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 40,000 | 40,000 | 0 | 0.68 | 0.55 | -0.13 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 38,640 | 38,684 | +44 | 0.21 | 0.17 | -0.03 | buy |
| PFM Health Sciences, LP | 35,438 | 38,575 | +3,137 | 1.20 | 1.12 | -0.08 | buy |
| STEMPOINT CAPITAL LP | 56,267 | 37,243 | -19,024 | 3.48 | 2.16 | -1.33 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,145 | 36,187 | -1,958 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 35,000 | 35,000 | 0 | 0.56 | 0.42 | -0.14 | hold |
| University of Wisconsin Foundation | 25,215 | 34,730 | +9,515 | 7.21 | 9.21 | +1.99 | buy |
| B Group, Inc. | 33,237 | 33,237 | 0 | 7.94 | 6.32 | -1.62 | hold |
| RHUMBLINE ADVISERS | 32,879 | 32,347 | -532 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 31,161 | 31,574 | +413 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 26,323 | 30,210 | +3,887 | 2.34 | 2.31 | -0.04 | buy |
| LORD, ABBETT & CO. LLC | 29,619 | 29,662 | +43 | 0.03 | 0.03 | -0.00 | buy |
| Clearbridge Investments, LLC | 0 | 27,981 | +27,981 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 11,614 | 27,889 | +16,275 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 45,469 | 27,205 | -18,264 | 8.62 | 5.62 | -3.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,744 | 27,185 | -559 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 35,146 | 27,162 | -7,984 | 0.01 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 27,058 | +27,058 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,477 | 26,603 | -874 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,093 | 26,147 | -3,946 | 0.01 | 0.01 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 25,790 | +25,790 | 0.00 | 0.28 | +0.28 | buy |
| Allianz Asset Management GmbH | 14,030 | 25,744 | +11,714 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 24,739 | +24,739 | 0.00 | 0.02 | +0.02 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 24,390 | +24,390 | 0.00 | 0.22 | +0.22 | buy |
| CITIGROUP INC | 5,646 | 23,599 | +17,953 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 3,173 | 21,164 | +17,991 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 23,251 | 21,126 | -2,125 | 0.11 | 0.11 | +0.00 | sell |
| SummitTX Capital, L.P. | 36,838 | 19,779 | -17,059 | 0.38 | 0.17 | -0.20 | sell |
| PRUDENTIAL FINANCIAL INC | 30,510 | 19,541 | -10,969 | 0.01 | 0.01 | -0.00 | sell |