| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 750,230 | 1,164,035 | +413,805 | 0.75 | 1.42 | +0.67 | buy |
| BAKER BROS. ADVISORS LP | 131,533 | 323,105 | +191,572 | 0.07 | 0.19 | +0.12 | buy |
| Cormorant Asset Management, LP | 685,000 | 870,000 | +185,000 | 1.64 | 2.65 | +1.02 | buy |
| STEMPOINT CAPITAL LP | 29,259 | 174,034 | +144,775 | 0.36 | 3.00 | +2.65 | buy |
| FRED ALGER MANAGEMENT, LLC | 2,595 | 10,423 | +7,828 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 24,381 | 31,605 | +7,224 | 0.20 | 0.33 | +0.13 | buy |
| ALPS ADVISORS INC | 13,342 | 13,429 | +87 | 0.00 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,260 | 2,297 | +37 | 0.05 | 0.06 | +0.02 | buy |
| PCG Wealth Advisors, LLC | 17,441 | 17,359 | -82 | 0.31 | 0.39 | +0.07 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 67,296 | 67,045 | -251 | 0.69 | 0.87 | +0.18 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 63,361 | 39,999 | -23,362 | 0.01 | 0.01 | -0.00 | sell |
| Ovata Capital Management Ltd | 40,000 | 9,777 | -30,223 | 0.90 | 0.24 | -0.66 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 415,000 | 368,000 | -47,000 | 2.65 | 3.11 | +0.46 | sell |
| Ally Bridge Group (NY) LLC | 153,379 | 73,185 | -80,194 | 3.78 | 2.25 | -1.53 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 264,688 | 166,056 | -98,632 | 0.11 | 0.08 | -0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 164,431 | 57,500 | -106,931 | 5.73 | 2.68 | -3.05 | sell |
| Octagon Capital Advisors LP | 260,000 | 130,000 | -130,000 | 1.77 | 1.20 | -0.58 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 283,424 | 152,307 | -131,117 | 1.60 | 1.39 | -0.20 | sell |
| PFM Health Sciences, LP | 453,146 | 183,092 | -270,054 | 0.93 | 0.60 | -0.33 | sell |
| Soleus Capital Management, L.P. | 533,015 | 259,398 | -273,617 | 1.94 | 1.16 | -0.79 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,134,083 | 854,083 | -280,000 | 0.09 | 0.09 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,235,599 | 761,955 | -473,644 | 0.68 | 0.51 | -0.17 | sell |