| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,533,405 | 2,763,859 | +230,454 | 0.05 | 0.07 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,974,585 | 2,374,085 | +399,500 | 0.14 | 0.20 | +0.06 | buy |
| BlackRock, Inc. | 1,590,128 | 1,801,080 | +210,952 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 752,921 | 1,564,554 | +811,633 | 1.19 | 2.40 | +1.21 | buy |
| Point72 Asset Management, L.P. | 954,075 | 1,495,986 | +541,911 | 0.09 | 0.17 | +0.08 | buy |
| VANGUARD GROUP INC | 1,215,644 | 1,267,286 | +51,642 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,473,075 | 1,003,490 | -469,585 | 0.01 | 0.01 | -0.00 | sell |
| Cormorant Asset Management, LP | 1,625,000 | 1,000,000 | -625,000 | 5.09 | 3.66 | -1.43 | sell |
| STATE STREET CORP | 698,093 | 907,108 | +209,015 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 966,740 | 859,166 | -107,574 | 2.81 | 2.43 | -0.37 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 686,931 | 840,851 | +153,920 | 0.52 | 0.68 | +0.16 | buy |
| BAKER BROS. ADVISORS LP | 689,488 | 689,488 | 0 | 0.28 | 0.26 | -0.02 | hold |
| MORGAN STANLEY | 1,226,339 | 643,495 | -582,844 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 225,992 | 593,021 | +367,029 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 530,988 | 500,551 | -30,437 | 0.18 | 0.19 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 453,403 | 482,861 | +29,458 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 451,731 | 457,032 | +5,301 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 45,952 | 417,669 | +371,717 | 0.01 | 0.10 | +0.09 | buy |
| Assenagon Asset Management S.A. | 604,298 | 409,779 | -194,519 | 0.04 | 0.03 | -0.01 | sell |
| CIBC Asset Management Inc | 388,759 | 388,759 | 0 | 0.05 | 0.06 | +0.01 | hold |
| FRANKLIN RESOURCES INC | 314,150 | 314,157 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 167,600 | 198,895 | +31,295 | 0.72 | 0.85 | +0.13 | buy |
| Sofinnova Investments, Inc. | 15,717 | 172,833 | +157,116 | 0.04 | 0.56 | +0.52 | buy |
| 5AM Venture Management, LLC | 170,000 | 170,000 | 0 | 2.75 | 3.30 | +0.55 | hold |
| NORTHERN TRUST CORP | 213,712 | 168,353 | -45,359 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,444 | 161,661 | +9,217 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 27,570 | 160,818 | +133,248 | 0.02 | 0.14 | +0.12 | buy |
| Alyeska Investment Group, L.P. | 125,000 | 141,516 | +16,516 | 0.02 | 0.02 | +0.00 | buy |
| Velan Capital Investment Management LP | 149,334 | 132,805 | -16,529 | 6.28 | 6.61 | +0.33 | sell |
| Logos Global Management LP | 225,000 | 125,000 | -100,000 | 1.26 | 0.65 | -0.61 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 109,177 | +109,177 | 0.00 | 0.28 | +0.28 | buy |
| Exome Asset Management LLC | 59,002 | 101,996 | +42,994 | 2.05 | 3.57 | +1.52 | buy |
| UBS Group AG | 86,534 | 96,812 | +10,278 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 67,288 | 95,002 | +27,714 | 1.04 | 1.23 | +0.19 | buy |
| BARCLAYS PLC | 88,724 | 76,637 | -12,087 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 70,445 | 76,218 | +5,773 | 0.07 | 0.09 | +0.02 | buy |
| Tri Locum Partners LP | 195,432 | 75,986 | -119,446 | 2.49 | 0.93 | -1.57 | sell |
| MARSHALL WACE, LLP | 0 | 68,141 | +68,141 | 0.00 | 0.00 | +0.00 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 7.23 | 5.14 | -2.09 | hold |
| Candriam S.C.A. | 63,671 | 62,866 | -805 | 0.02 | 0.02 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 55,881 | 61,241 | +5,360 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 84,713 | 60,578 | -24,135 | 0.31 | 0.27 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 109,757 | 57,901 | -51,856 | 1.21 | 0.73 | -0.48 | sell |
| Qube Research & Technologies Ltd | 0 | 57,304 | +57,304 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 52,553 | 56,288 | +3,735 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 10,000 | 51,210 | +41,210 | 0.09 | 0.39 | +0.31 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 74,087 | 49,751 | -24,336 | 4.35 | 2.72 | -1.62 | sell |
| FMR LLC | 38,100 | 43,211 | +5,111 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 63,938 | 40,884 | -23,054 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 118,121 | 39,660 | -78,461 | 0.15 | 0.05 | -0.10 | sell |
| Nuveen, LLC | 38,549 | 38,549 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 24,805 | 37,573 | +12,768 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 37,414 | +37,414 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,131 | 35,829 | -20,302 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 30,800 | 35,500 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 34,928 | +34,928 | 0.00 | 0.08 | +0.08 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 32,186 | +32,186 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 13,003 | 31,687 | +18,684 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 35,000 | 31,500 | -3,500 | 1.27 | 1.60 | +0.33 | sell |
| CONGRESS ASSET MANAGEMENT CO | 0 | 30,439 | +30,439 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,927 | 29,337 | -17,590 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 28,966 | +28,966 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 276,950 | 28,571 | -248,379 | 3.85 | 0.31 | -3.55 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,900 | 28,102 | +8,202 | 0.08 | 0.12 | +0.03 | buy |
| Knott David M Jr | 0 | 28,000 | +28,000 | 0.00 | 0.62 | +0.62 | buy |
| RHUMBLINE ADVISERS | 27,341 | 26,794 | -547 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 13,938 | 26,208 | +12,270 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 96,945 | 23,756 | -73,189 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 5,750 | 23,251 | +17,501 | 0.01 | 0.02 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,873 | 22,836 | -1,037 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 25,328 | 22,529 | -2,799 | 0.03 | 0.03 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 14,580 | 21,904 | +7,324 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 21,684 | +21,684 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 15,939 | 20,868 | +4,929 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 4,800 | 20,001 | +15,201 | 0.05 | 0.26 | +0.21 | buy |
| D. E. Shaw & Co., Inc. | 19,056 | 19,796 | +740 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,346 | 18,583 | +2,237 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 18,040 | 18,060 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 16,670 | 16,824 | +154 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 16,628 | +16,628 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 15,268 | +15,268 | 0.00 | 0.00 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 0 | 14,483 | +14,483 | 0.00 | 0.22 | +0.22 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 45,082 | 13,898 | -31,184 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 12,124 | 13,856 | +1,732 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,252 | 13,605 | +2,353 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,496 | +13,496 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 11,172 | +11,172 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,520 | 10,520 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUSSMAN STRATEGIC ADVISORS, INC. | 10,500 | 10,500 | 0 | 0.10 | 0.12 | +0.02 | hold |
| ALPS ADVISORS INC | 10,994 | 10,424 | -570 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,759 | 9,033 | -5,726 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 8,905 | +8,905 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 8,269 | +8,269 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 5,261 | 8,079 | +2,818 | 0.01 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 10,366 | 7,798 | -2,568 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 8,719 | 7,754 | -965 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 629 | 7,129 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| Phoenix Financial Ltd. | 0 | 6,817 | +6,817 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 6,495 | 6,660 | +165 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,600 | 6,600 | 0 | 0.00 | 0.00 | +0.00 | hold |