| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 738,666 | +738,666 | 0.00 | 0.03 | +0.03 | buy |
| Verition Fund Management LLC | 0 | 703,000 | +703,000 | 0.00 | 0.16 | +0.16 | buy |
| Point72 Asset Management, L.P. | 0 | 692,252 | +692,252 | 0.00 | 0.05 | +0.05 | buy |
| PFM Health Sciences, LP | 0 | 656,548 | +656,548 | 0.00 | 0.88 | +0.88 | buy |
| Cormorant Asset Management, LP | 0 | 633,345 | +633,345 | 0.00 | 0.68 | +0.68 | buy |
| VANGUARD GROUP INC | 0 | 370,938 | +370,938 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 0 | 353,626 | +353,626 | 0.00 | 0.54 | +0.54 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 346,665 | +346,665 | 0.00 | 1.47 | +1.47 | buy |
| Velan Capital Investment Management LP | 0 | 345,666 | +345,666 | 0.00 | 5.45 | +5.45 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 299,636 | +299,636 | 0.00 | 3.76 | +3.76 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 283,841 | +283,841 | 0.00 | 1.95 | +1.95 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 278,862 | +278,862 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 248,761 | +248,761 | 0.00 | 2.72 | +2.72 | buy |
| Ikarian Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 1.22 | +1.22 | buy |
| CIBC Asset Management Inc | 0 | 173,868 | +173,868 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 98,049 | +98,049 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 92,958 | +92,958 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 80,804 | +80,804 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 70,424 | +70,424 | 0.00 | 0.93 | +0.93 | buy |
| Blackstone Inc. | 0 | 70,273 | +70,273 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 66,488 | +66,488 | 0.00 | 0.01 | +0.01 | buy |
| 72 Investment Holdings, LLC | 0 | 65,933 | +65,933 | 0.00 | 6.52 | +6.52 | buy |
| CITADEL ADVISORS LLC | 0 | 56,479 | +56,479 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 48,842 | +48,842 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 48,284 | +48,284 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 46,710 | +46,710 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 0 | 30,708 | +30,708 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 30,037 | +30,037 | 0.00 | 0.12 | +0.12 | buy |
| Qube Research & Technologies Ltd | 0 | 25,104 | +25,104 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 23,524 | +23,524 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 22,346 | +22,346 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 22,278 | +22,278 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 21,152 | +21,152 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 0 | 19,364 | +19,364 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 18,000 | +18,000 | 0.00 | 0.02 | +0.02 | buy |
| Wildcat Capital Management, LLC | 0 | 16,756 | +16,756 | 0.00 | 0.13 | +0.13 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 15,705 | +15,705 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 13,710 | +13,710 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 13,139 | +13,139 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 11,531 | +11,531 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 11,481 | +11,481 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 10,576 | +10,576 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 9,426 | +9,426 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 9,245 | +9,245 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,392 | +1,392 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 115 | +115 | 0.00 | 0.00 | +0.00 | buy |
| FSA Wealth Management LLC | 0 | 21 | +21 | 0.00 | 0.00 | 0.00 | buy |