| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 870,000 | 1,693,219 | +823,219 | 2.65 | 7.16 | +4.50 | buy |
| BlackRock, Inc. | 1,302,435 | 1,462,445 | +160,010 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,164,035 | 1,329,735 | +165,700 | 1.44 | 2.85 | +1.41 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,120,080 | 1,208,522 | +88,442 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 80,500 | 1,163,526 | +1,083,026 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,038,994 | 1,063,639 | +24,645 | 0.00 | 0.00 | +0.00 | buy |
| Capital Research Global Investors | 997,094 | 993,569 | -3,525 | 0.01 | 0.02 | +0.00 | sell |
| VR Adviser, LLC | 706,131 | 989,985 | +283,854 | 2.13 | 5.23 | +3.10 | buy |
| JANUS HENDERSON GROUP PLC | 523,566 | 929,523 | +405,957 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 789,624 | 768,655 | -20,969 | 0.00 | 0.00 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 761,955 | 761,955 | 0 | 0.51 | 0.78 | +0.27 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 854,083 | 605,010 | -249,073 | 0.09 | 0.08 | -0.01 | sell |
| Assenagon Asset Management S.A. | 10,096 | 559,082 | +548,986 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 1,033,244 | 521,273 | -511,971 | 0.21 | 0.11 | -0.10 | sell |
| Verition Fund Management LLC | 559,151 | 464,508 | -94,643 | 0.22 | 0.18 | -0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 398,838 | 406,711 | +7,873 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 445,233 | 389,835 | -55,398 | 0.01 | 0.01 | -0.00 | sell |
| CIBC Asset Management Inc | 248,939 | 366,756 | +117,817 | 0.05 | 0.09 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 323,105 | 331,533 | +8,428 | 0.19 | 0.27 | +0.08 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 368,000 | 303,000 | -65,000 | 3.11 | 3.99 | +0.88 | sell |
| Velan Capital Investment Management LP | 350,666 | 300,000 | -50,666 | 21.90 | 19.92 | -1.98 | sell |
| GOLDMAN SACHS GROUP INC | 279,620 | 279,395 | -225 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 259,398 | 243,540 | -15,858 | 1.24 | 1.42 | +0.18 | sell |
| Alyeska Investment Group, L.P. | 0 | 226,788 | +226,788 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 273,895 | 188,367 | -85,528 | 0.00 | 0.00 | -0.00 | sell |
| 5AM Venture Management, LLC | 340,000 | 170,000 | -170,000 | 4.04 | 3.12 | -0.92 | sell |
| NORTHERN TRUST CORP | 152,267 | 167,590 | +15,323 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 166,056 | 164,912 | -1,144 | 0.08 | 0.10 | +0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,994 | 157,925 | +128,931 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,169 | 150,892 | +146,723 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 137,052 | 142,892 | +5,840 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 174,034 | 134,178 | -39,856 | 3.00 | 2.59 | -0.41 | sell |
| UBS Group AG | 29,550 | 120,267 | +90,717 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 183,092 | 119,509 | -63,583 | 0.60 | 0.70 | +0.10 | sell |
| NORGES BANK | 5,000 | 118,900 | +113,900 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 162,031 | 117,970 | -44,061 | 0.05 | 0.05 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 75,187 | 116,062 | +40,875 | 0.02 | 0.03 | +0.02 | buy |
| Polar Asset Management Partners Inc. | 0 | 98,617 | +98,617 | 0.00 | 0.11 | +0.11 | buy |
| CITIGROUP INC | 83,350 | 95,047 | +11,697 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 48,034 | 93,190 | +45,156 | 0.00 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 152,307 | 91,583 | -60,724 | 1.43 | 1.30 | -0.13 | sell |
| Walleye Capital LLC | 55,613 | 89,613 | +34,000 | 0.03 | 0.07 | +0.03 | buy |
| Invesco Ltd. | 107,713 | 86,983 | -20,730 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 18,040 | 78,627 | +60,587 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 67,045 | 72,516 | +5,471 | 0.87 | 1.25 | +0.38 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 57,500 | 67,500 | +10,000 | 2.68 | 5.23 | +2.55 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 8.16 | 10.33 | +2.18 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 219,907 | 63,934 | -155,973 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 170,095 | 58,305 | -111,790 | 0.01 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 43,898 | 52,898 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 46,364 | 47,993 | +1,629 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 48,207 | 46,856 | -1,351 | 0.00 | 0.00 | +0.00 | sell |
| First Turn Management, LLC | 0 | 45,536 | +45,536 | 0.00 | 0.63 | +0.63 | buy |
| Pictet Asset Management Holding SA | 0 | 45,427 | +45,427 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 73,185 | 44,982 | -28,203 | 2.25 | 2.97 | +0.71 | sell |
| Schonfeld Strategic Advisors LLC | 28,451 | 43,100 | +14,649 | 0.01 | 0.02 | +0.01 | buy |
| Simplify Asset Management Inc. | 0 | 43,085 | +43,085 | 0.00 | 0.23 | +0.23 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 39,999 | 39,999 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,139 | 38,483 | +3,344 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 37,130 | 37,288 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 37,269 | +37,269 | 0.00 | 0.59 | +0.59 | buy |
| JANE STREET GROUP, LLC | 38,545 | 37,144 | -1,401 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 35,359 | 33,629 | -1,730 | 0.01 | 0.01 | +0.00 | sell |
| Qube Research & Technologies Ltd | 44,703 | 31,999 | -12,704 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 31,605 | 30,677 | -928 | 0.33 | 0.44 | +0.11 | sell |
| Ensign Peak Advisors, Inc | 0 | 27,650 | +27,650 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,490 | 26,503 | -11,987 | 0.05 | 0.05 | -0.00 | sell |
| Swiss National Bank | 25,100 | 26,100 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 23,116 | 22,769 | -347 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,766 | 20,066 | -2,700 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,868 | 18,615 | +2,747 | 0.00 | 0.00 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 17,359 | 17,282 | -77 | 0.39 | 0.49 | +0.11 | sell |
| SIMPLEX TRADING, LLC | 12,418 | 16,854 | +4,436 | 0.02 | 0.04 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 10,313 | 15,594 | +5,281 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,315 | 15,324 | +5,009 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 13,429 | 15,066 | +1,637 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 13,829 | 14,439 | +610 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,451 | 12,726 | +275 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 11,634 | +11,634 | 0.00 | 0.03 | +0.03 | buy |
| Jump Financial, LLC | 0 | 11,188 | +11,188 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,877 | 11,135 | +258 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 10,951 | 10,951 | 0 | 0.22 | 0.31 | +0.10 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,648 | 10,682 | -1,966 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 10,131 | 10,675 | +544 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 21,000 | 10,500 | -10,500 | 0.30 | 0.24 | -0.06 | sell |
| Woodline Partners LP | 0 | 9,948 | +9,948 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 7,814 | 9,693 | +1,879 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 10,423 | 9,496 | -927 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 15,432 | 9,115 | -6,317 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 5,866 | 8,612 | +2,746 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 9,220 | 8,574 | -646 | 0.00 | 0.00 | +0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 8,481 | +8,481 | 0.00 | 0.06 | +0.06 | buy |
| Ellsworth Advisors, LLC | 0 | 8,150 | +8,150 | 0.00 | 0.16 | +0.16 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,000 | 7,847 | +847 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 14,658 | 7,782 | -6,876 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,268 | 6,704 | -18,564 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 7,047 | 6,559 | -488 | 0.02 | 0.02 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 3,771 | 6,338 | +2,567 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,270 | 6,040 | -230 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 883 | 5,873 | +4,990 | 0.00 | 0.01 | +0.01 | buy |