| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 870,000 | 1,693,219 | +823,219 | 2.65 | 7.16 | +4.50 | buy |
| VR Adviser, LLC | 706,131 | 989,985 | +283,854 | 2.13 | 5.23 | +3.10 | buy |
| PERCEPTIVE ADVISORS LLC | 1,164,035 | 1,329,735 | +165,700 | 1.42 | 2.82 | +1.40 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 57,500 | 67,500 | +10,000 | 2.68 | 5.23 | +2.55 | buy |
| BAKER BROS. ADVISORS LP | 323,105 | 331,533 | +8,428 | 0.19 | 0.27 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 67,045 | 72,516 | +5,471 | 0.87 | 1.25 | +0.38 | buy |
| ALPS ADVISORS INC | 13,429 | 15,066 | +1,637 | 0.01 | 0.01 | +0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 4,006 | 4,047 | +41 | 0.00 | 0.01 | +0.00 | buy |
| PCG Wealth Advisors, LLC | 17,359 | 17,282 | -77 | 0.39 | 0.49 | +0.11 | sell |
| FRED ALGER MANAGEMENT, LLC | 10,423 | 9,496 | -927 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 31,605 | 30,677 | -928 | 0.33 | 0.44 | +0.11 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 166,056 | 164,912 | -1,144 | 0.08 | 0.10 | +0.02 | sell |
| VIRTUS ADVISERS, LLC | 2,297 | 1,001 | -1,296 | 0.06 | 0.03 | -0.03 | sell |
| Capital Research Global Investors | 997,094 | 993,569 | -3,525 | 0.01 | 0.02 | +0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 21,000 | 10,500 | -10,500 | 0.30 | 0.24 | -0.06 | sell |
| Soleus Capital Management, L.P. | 259,398 | 243,540 | -15,858 | 1.24 | 1.42 | +0.18 | sell |
| Ally Bridge Group (NY) LLC | 73,185 | 44,982 | -28,203 | 2.25 | 2.97 | +0.71 | sell |
| STEMPOINT CAPITAL LP | 174,034 | 134,178 | -39,856 | 3.00 | 2.59 | -0.41 | sell |
| Candriam S.C.A. | 162,031 | 117,970 | -44,061 | 0.05 | 0.05 | -0.00 | sell |
| Velan Capital Investment Management LP | 350,666 | 300,000 | -50,666 | 21.90 | 19.92 | -1.98 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 152,307 | 91,583 | -60,724 | 1.39 | 1.27 | -0.12 | sell |
| PFM Health Sciences, LP | 183,092 | 119,509 | -63,583 | 0.60 | 0.57 | -0.03 | sell |
| Pale Fire Capital SE | 67,284 | 3,369 | -63,915 | 0.61 | 0.06 | -0.55 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 368,000 | 303,000 | -65,000 | 3.11 | 3.99 | +0.88 | sell |
| 5AM Venture Management, LLC | 340,000 | 170,000 | -170,000 | 4.04 | 3.12 | -0.92 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 854,083 | 605,010 | -249,073 | 0.09 | 0.08 | -0.01 | sell |