| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 689,488 | 1,126,488 | +437,000 | 0.26 | 1.94 | +1.68 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 500,551 | 933,061 | +432,510 | 0.19 | 1.87 | +1.68 | buy |
| PERCEPTIVE ADVISORS LLC | 1,564,554 | 1,995,986 | +431,432 | 2.39 | 10.49 | +8.09 | buy |
| Logos Global Management LP | 125,000 | 375,000 | +250,000 | 0.65 | 7.37 | +6.71 | buy |
| Vivo Capital, LLC | 198,895 | 328,895 | +130,000 | 0.85 | 6.27 | +5.42 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 840,851 | 903,351 | +62,500 | 0.68 | 3.40 | +2.72 | buy |
| Ikarian Capital, LLC | 28,571 | 86,581 | +58,010 | 0.31 | 3.30 | +3.00 | buy |
| Candriam S.C.A. | 62,866 | 110,590 | +47,724 | 0.02 | 0.16 | +0.15 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 49,751 | 83,036 | +33,285 | 2.72 | 16.62 | +13.89 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 51,210 | 82,465 | +31,255 | 0.39 | 3.52 | +3.12 | buy |
| SummitTX Capital, L.P. | 34,928 | 41,629 | +6,701 | 0.08 | 0.37 | +0.29 | buy |
| B Group, Inc. | 31,500 | 33,237 | +1,737 | 1.60 | 7.26 | +5.66 | buy |
| China Universal Asset Management Co., Ltd. | 3,689 | 4,875 | +1,186 | 0.02 | 0.11 | +0.09 | buy |
| CONGRESS ASSET MANAGEMENT CO | 30,439 | 31,246 | +807 | 0.01 | 0.06 | +0.05 | buy |
| Coastal Bridge Advisors, LLC | 3,846 | 4,154 | +308 | 0.02 | 0.09 | +0.08 | buy |
| GF FUND MANAGEMENT CO. LTD. | 453 | 490 | +37 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 3,900 | 3,500 | -400 | 0.00 | 0.01 | +0.00 | sell |
| Lion Point Capital, LP | 5,700 | 4,450 | -1,250 | 1.72 | 6.79 | +5.07 | sell |
| Virtus Investment Advisers, LLC | 2,527 | 989 | -1,538 | 0.04 | 0.08 | +0.04 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 10,500 | 8,400 | -2,100 | 0.12 | 0.60 | +0.48 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 13,898 | 10,140 | -3,758 | 0.00 | 0.01 | +0.01 | sell |
| PFM Health Sciences, LP | 60,578 | 31,163 | -29,415 | 0.25 | 0.92 | +0.67 | sell |
| Velan Capital Investment Management LP | 132,805 | 100,781 | -32,024 | 6.61 | 17.28 | +10.67 | sell |
| Exome Asset Management LLC | 101,996 | 58,122 | -43,874 | 3.57 | 8.46 | +4.89 | sell |
| Sofinnova Investments, Inc. | 172,833 | 125,722 | -47,111 | 0.50 | 1.60 | +1.10 | sell |
| Cormorant Asset Management, LP | 1,000,000 | 950,000 | -50,000 | 3.66 | 12.95 | +9.29 | sell |
| Alyeska Investment Group, L.P. | 141,516 | 74,376 | -67,140 | 0.02 | 0.06 | +0.04 | sell |
| HighVista Strategies LLC | 95,002 | 25,841 | -69,161 | 1.23 | 1.96 | +0.73 | sell |
| READYSTATE ASSET MANAGEMENT LP | 109,177 | 36,792 | -72,385 | 0.28 | 0.48 | +0.20 | sell |
| Soleus Capital Management, L.P. | 859,166 | 362,966 | -496,200 | 2.43 | 4.54 | +2.10 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,374,085 | 965,313 | -1,408,772 | 0.20 | 0.43 | +0.23 | sell |