| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,763,859 | 3,240,086 | +476,227 | 0.07 | 0.43 | +0.36 | buy |
| BlackRock, Inc. | 1,801,080 | 2,078,500 | +277,420 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,564,554 | 1,995,986 | +431,432 | 2.40 | 10.78 | +8.38 | buy |
| VANGUARD GROUP INC | 1,267,286 | 1,460,933 | +193,647 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 43,211 | 1,358,675 | +1,315,464 | 0.00 | 0.02 | +0.02 | buy |
| Orbis Allan Gray Ltd | 0 | 1,255,162 | +1,255,162 | 0.00 | 1.55 | +1.55 | buy |
| BAKER BROS. ADVISORS LP | 689,488 | 1,126,488 | +437,000 | 0.26 | 1.94 | +1.68 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,374,085 | 965,313 | -1,408,772 | 0.20 | 0.43 | +0.23 | sell |
| Cormorant Asset Management, LP | 1,000,000 | 950,000 | -50,000 | 3.66 | 15.87 | +12.22 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 500,551 | 933,061 | +432,510 | 0.19 | 1.87 | +1.68 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 840,851 | 903,351 | +62,500 | 0.68 | 3.41 | +2.73 | buy |
| MORGAN STANLEY | 643,495 | 889,889 | +246,394 | 0.00 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 907,108 | 882,215 | -24,893 | 0.00 | 0.01 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,003,490 | 785,987 | -217,503 | 0.01 | 0.02 | +0.02 | sell |
| GOLDMAN SACHS GROUP INC | 593,021 | 716,184 | +123,163 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 457,032 | 562,379 | +105,347 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 76,637 | 530,751 | +454,114 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 482,861 | 522,763 | +39,902 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 1,495,986 | 492,346 | -1,003,640 | 0.17 | 0.23 | +0.06 | sell |
| Assenagon Asset Management S.A. | 409,779 | 408,787 | -992 | 0.03 | 0.18 | +0.15 | sell |
| Logos Global Management LP | 125,000 | 375,000 | +250,000 | 0.65 | 7.37 | +6.71 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 373,787 | +373,787 | 0.00 | 1.13 | +1.13 | buy |
| Soleus Capital Management, L.P. | 859,166 | 362,966 | -496,200 | 2.43 | 4.54 | +2.10 | sell |
| FRANKLIN RESOURCES INC | 314,157 | 356,074 | +41,917 | 0.00 | 0.03 | +0.02 | buy |
| Vivo Capital, LLC | 198,895 | 328,895 | +130,000 | 0.85 | 6.27 | +5.42 | buy |
| Hood River Capital Management LLC | 0 | 289,467 | +289,467 | 0.00 | 0.94 | +0.94 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 276,392 | +276,392 | 0.00 | 0.05 | +0.05 | buy |
| Pictet Asset Management Holding SA | 0 | 240,588 | +240,588 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,661 | 198,301 | +36,640 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 168,353 | 192,284 | +23,931 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 185,000 | +185,000 | 0.00 | 3.92 | +3.92 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 61,241 | 176,562 | +115,321 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 57,304 | 168,897 | +111,593 | 0.00 | 0.07 | +0.07 | buy |
| Aberdeen Group plc | 0 | 134,992 | +134,992 | 0.00 | 0.06 | +0.06 | buy |
| Sofinnova Investments, Inc. | 172,833 | 125,722 | -47,111 | 0.56 | 1.60 | +1.04 | sell |
| Candriam S.C.A. | 62,866 | 110,590 | +47,724 | 0.02 | 0.16 | +0.15 | buy |
| Woodline Partners LP | 417,669 | 105,412 | -312,257 | 0.10 | 0.12 | +0.02 | sell |
| Velan Capital Investment Management LP | 132,805 | 100,781 | -32,024 | 6.61 | 17.28 | +10.67 | sell |
| ORBIMED ADVISORS LLC | 0 | 94,500 | +94,500 | 0.00 | 0.57 | +0.57 | buy |
| UBS Group AG | 96,812 | 89,200 | -7,612 | 0.00 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 28,966 | 88,704 | +59,738 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 28,571 | 86,581 | +58,010 | 0.31 | 3.30 | +3.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 49,751 | 83,036 | +33,285 | 2.72 | 16.62 | +13.89 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 51,210 | 82,465 | +31,255 | 0.39 | 3.52 | +3.12 | buy |
| ALGERT GLOBAL LLC | 160,818 | 80,640 | -80,178 | 0.14 | 0.37 | +0.23 | sell |
| Bank of New York Mellon Corp | 56,288 | 77,897 | +21,609 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 20,868 | 77,088 | +56,220 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 15,268 | 75,366 | +60,098 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 141,516 | 74,376 | -67,140 | 0.02 | 0.06 | +0.04 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 69,712 | +69,712 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 68,141 | 69,242 | +1,101 | 0.00 | 0.02 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 67,100 | +67,100 | 0.00 | 0.31 | +0.31 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 66,230 | +66,230 | 0.00 | 0.03 | +0.03 | buy |
| 72 Investment Holdings, LLC | 65,933 | 65,933 | 0 | 5.14 | 38.42 | +33.28 | hold |
| Ensign Peak Advisors, Inc | 0 | 64,283 | +64,283 | 0.00 | 0.03 | +0.03 | buy |
| Exome Asset Management LLC | 101,996 | 58,122 | -43,874 | 3.57 | 8.46 | +4.89 | sell |
| JPMORGAN CHASE & CO | 26,208 | 55,300 | +29,092 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,856 | 50,811 | +36,955 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 38,549 | 49,970 | +11,421 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 46,457 | +46,457 | 0.00 | 3.00 | +3.00 | buy |
| TD ASSET MANAGEMENT INC | 40,884 | 46,146 | +5,262 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 41,731 | +41,731 | 0.00 | 2.30 | +2.30 | buy |
| SummitTX Capital, L.P. | 34,928 | 41,629 | +6,701 | 0.08 | 0.37 | +0.30 | buy |
| Swiss National Bank | 35,500 | 40,500 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.60 | +0.60 | buy |
| D. E. Shaw & Co., Inc. | 19,796 | 37,481 | +17,685 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 37,377 | +37,377 | 0.00 | 0.02 | +0.02 | buy |
| Empowered Funds, LLC | 0 | 36,852 | +36,852 | 0.00 | 0.09 | +0.09 | buy |
| READYSTATE ASSET MANAGEMENT LP | 109,177 | 36,792 | -72,385 | 0.28 | 0.48 | +0.20 | sell |
| First Turn Management, LLC | 0 | 35,749 | +35,749 | 0.00 | 1.20 | +1.20 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,756 | 35,288 | +11,532 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 7,798 | 34,917 | +27,119 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 6,357 | 33,300 | +26,943 | 0.02 | 0.43 | +0.41 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,829 | 33,291 | -2,538 | 0.00 | 0.01 | +0.01 | sell |
| B Group, Inc. | 31,500 | 33,237 | +1,737 | 1.60 | 7.26 | +5.66 | buy |
| CONGRESS ASSET MANAGEMENT CO | 30,439 | 31,246 | +807 | 0.01 | 0.06 | +0.05 | buy |
| PFM Health Sciences, LP | 60,578 | 31,163 | -29,415 | 0.27 | 0.93 | +0.66 | sell |
| LORD, ABBETT & CO. LLC | 0 | 30,756 | +30,756 | 0.00 | 0.03 | +0.03 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 30,000 | +30,000 | 0.00 | 0.19 | +0.19 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,904 | 28,828 | +6,924 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,794 | 28,324 | +1,530 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 95,002 | 25,841 | -69,161 | 1.23 | 1.96 | +0.73 | sell |
| Neuberger Berman Group LLC | 0 | 25,678 | +25,678 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,836 | 25,559 | +2,723 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 13,605 | 25,235 | +11,630 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 18,060 | 25,070 | +7,010 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 25,000 | +25,000 | 0.00 | 0.49 | +0.49 | buy |
| DIMENSIONAL FUND ADVISORS LP | 37,414 | 23,543 | -13,871 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 23,251 | 23,251 | 0 | 0.02 | 0.11 | +0.09 | hold |
| TWO SIGMA INVESTMENTS, LP | 5,508 | 23,098 | +17,590 | 0.00 | 0.01 | +0.01 | buy |
| TFG Asset Management GP Ltd | 0 | 22,952 | +22,952 | 0.00 | 1.43 | +1.43 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 22,715 | +22,715 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 37,573 | 22,240 | -15,333 | 0.01 | 0.02 | +0.02 | sell |
| Man Group plc | 0 | 21,170 | +21,170 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 21,067 | +21,067 | 0.00 | 1.07 | +1.07 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 39,660 | 20,974 | -18,686 | 0.05 | 0.16 | +0.11 | sell |
| Informed Momentum Co LLC | 0 | 20,941 | +20,941 | 0.00 | 0.69 | +0.69 | buy |
| Russell Investments Group, Ltd. | 4,404 | 20,612 | +16,208 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 19,882 | +19,882 | 0.00 | 9.30 | +9.30 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,583 | 19,671 | +1,088 | 0.00 | 0.01 | +0.00 | buy |