| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nicholas Investment Partners, LP | 51,250 | 186,769 | +135,519 | 0.31 | 1.03 | +0.71 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,019,813 | 1,125,313 | +105,500 | 1.01 | 1.14 | +0.13 | buy |
| Alyeska Investment Group, L.P. | 52,247 | 150,592 | +98,345 | 0.01 | 0.04 | +0.03 | buy |
| Atika Capital Management LLC | 128,800 | 165,000 | +36,200 | 1.36 | 1.06 | -0.30 | buy |
| HighVista Strategies LLC | 35,587 | 51,125 | +15,538 | 0.82 | 1.14 | +0.31 | buy |
| Legato Capital Management LLC | 12,532 | 26,046 | +13,514 | 0.10 | 0.21 | +0.11 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 4,119 | 9,333 | +5,214 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 81,627 | 86,127 | +4,500 | 0.85 | 0.79 | -0.05 | buy |
| SIG BROKERAGE, LP | 20,292 | 24,600 | +4,308 | 0.04 | 0.05 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 364 | 379 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Grove Bank & Trust | 59 | 61 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 423,982 | 420,002 | -3,980 | 2.75 | 2.50 | -0.25 | sell |
| Rock Springs Capital Management LP | 26,757 | 20,326 | -6,431 | 0.13 | 0.10 | -0.04 | sell |
| MOODY ALDRICH PARTNERS LLC | 82,129 | 74,552 | -7,577 | 1.24 | 1.31 | +0.06 | sell |
| Candriam S.C.A. | 213,522 | 204,214 | -9,308 | 0.09 | 0.09 | -0.00 | sell |
| SummitTX Capital, L.P. | 100,044 | 63,866 | -36,178 | 0.26 | 0.16 | -0.10 | sell |
| Informed Momentum Co LLC | 76,640 | 39,080 | -37,560 | 0.74 | 0.34 | -0.40 | sell |
| PFM Health Sciences, LP | 172,137 | 121,222 | -50,915 | 1.32 | 1.01 | -0.30 | sell |
| Artisan Partners Limited Partnership | 382,121 | 258,269 | -123,852 | 0.05 | 0.04 | -0.01 | sell |
| Cormorant Asset Management, LP | 950,000 | 750,000 | -200,000 | 4.00 | 3.75 | -0.26 | sell |
| SAMLYN CAPITAL, LLC | 431,115 | 196,326 | -234,789 | 0.62 | 0.31 | -0.31 | sell |
| Sio Capital Management, LLC | 370,045 | 59,254 | -310,791 | 4.45 | 0.96 | -3.50 | sell |