| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 0 | 2,992,028 | +2,992,028 | 0.00 | 7.21 | +7.21 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,333,000 | +2,333,000 | 0.00 | 0.89 | +0.89 | buy |
| FMR LLC | 2,218,212 | 4,161,045 | +1,942,833 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 1,217,554 | 2,717,554 | +1,500,000 | 0.48 | 2.90 | +2.41 | buy |
| VR Adviser, LLC | 927,706 | 2,094,373 | +1,166,667 | 0.66 | 2.99 | +2.33 | buy |
| Fairmount Funds Management LLC | 1,928,503 | 2,762,837 | +834,334 | 2.12 | 9.03 | +6.92 | buy |
| Octagon Capital Advisors LP | 554,000 | 1,380,667 | +826,667 | 0.92 | 5.04 | +4.11 | buy |
| RTW INVESTMENTS, LP | 0 | 666,667 | +666,667 | 0.00 | 0.30 | +0.30 | buy |
| GREAT POINT PARTNERS LLC | 0 | 625,000 | +625,000 | 0.00 | 2.92 | +2.92 | buy |
| VANGUARD GROUP INC | 153,646 | 537,828 | +384,182 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 375,044 | +375,044 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 352,100 | +352,100 | 0.00 | 0.03 | +0.03 | buy |
| Vestal Point Capital, LP | 135,000 | 455,000 | +320,000 | 0.15 | 1.13 | +0.98 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 298,000 | +298,000 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 33,964 | 277,213 | +243,249 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 216,968 | +216,968 | 0.00 | 3.62 | +3.62 | buy |
| Walleye Capital LLC | 0 | 190,266 | +190,266 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,679 | 205,487 | +176,808 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 170,217 | +170,217 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 112,930 | +112,930 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.26 | +0.26 | buy |
| JANE STREET GROUP, LLC | 0 | 82,051 | +82,051 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 80,000 | +80,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 802 | 67,846 | +67,044 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 49,306 | 105,704 | +56,398 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 43,456 | +43,456 | 0.00 | 0.35 | +0.35 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 37,971 | +37,971 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 37,100 | +37,100 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 34,174 | +34,174 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 45,179 | 74,400 | +29,221 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 24,829 | +24,829 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,125 | +24,125 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,959 | +21,959 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 21,000 | +21,000 | 0.00 | 0.15 | +0.15 | buy |
| STATE STREET CORP | 0 | 20,398 | +20,398 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 16,996 | +16,996 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 16,018 | +16,018 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 15,495 | +15,495 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 14,505 | +14,505 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 14,500 | +14,500 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 3 | 14,403 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 13,942 | +13,942 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 13,642 | +13,642 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,371 | +13,371 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,995 | +12,995 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 12,253 | +12,253 | 0.00 | 0.03 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,090 | +12,090 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 10,345 | +10,345 | 0.00 | 0.08 | +0.08 | buy |
| Bank of New York Mellon Corp | 0 | 8,426 | +8,426 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 7,786 | +7,786 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 7,478 | +7,478 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 7,219 | +7,219 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 14,736 | 21,728 | +6,992 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 6,686 | +6,686 | 0.00 | 0.05 | +0.05 | buy |
| CITIGROUP INC | 17,407 | 22,736 | +5,329 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 15,301 | 18,491 | +3,190 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,824 | +1,824 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,430 | 3,897 | +1,467 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 363 | +363 | 0.00 | 0.01 | +0.01 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 10,784 | 10,784 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.10 | 0.25 | +0.15 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ADAR1 Capital Management, LLC | 481 | 0 | -481 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 26,267 | 25,536 | -731 | 0.01 | 0.02 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 40,841 | 36,367 | -4,474 | 0.00 | 0.01 | +0.00 | sell |
| Jefferies Financial Group Inc. | 13,200 | 7,600 | -5,600 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 17,888 | 4,012 | -13,876 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 236,979 | 186,979 | -50,000 | 0.29 | 0.52 | +0.22 | sell |
| 5AM Venture Management, LLC | 1,472,264 | 1,242,029 | -230,235 | 4.06 | 8.34 | +4.28 | sell |
| TANG CAPITAL MANAGEMENT LLC | 504,242 | 264,692 | -239,550 | 0.48 | 0.83 | +0.34 | sell |
| Nantahala Capital Management, LLC | 328,433 | 0 | -328,433 | 0.34 | 0.00 | -0.34 | sell |