| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,866,400 | 2,866,733 | +1,000,333 | 0.54 | 0.87 | +0.33 | buy |
| Vestal Point Capital, LP | 1,075,000 | 1,700,069 | +625,069 | 1.39 | 2.20 | +0.81 | buy |
| Octagon Capital Advisors LP | 2,110,167 | 2,341,667 | +231,500 | 7.82 | 8.36 | +0.53 | buy |
| Rhenman & Partners Asset Management AB | 114,000 | 126,627 | +12,627 | 0.26 | 0.26 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 180,000 | 189,000 | +9,000 | 0.01 | 0.01 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 17,683 | 18,285 | +602 | 0.08 | 0.06 | -0.02 | buy |
| ALPS ADVISORS INC | 23,932 | 23,684 | -248 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 106,434 | 80,584 | -25,850 | 1.99 | 1.32 | -0.67 | sell |
| BRAIDWELL LP | 1,206,589 | 375,355 | -831,234 | 0.78 | 0.24 | -0.54 | sell |
| Avidity Partners Management LP | 2,873,000 | 1,720,902 | -1,152,098 | 6.24 | 6.44 | +0.20 | sell |