| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 2,357,702 | +2,357,702 | 0.00 | 1.38 | +1.38 | buy |
| Point72 Asset Management, L.P. | 193,600 | 1,486,944 | +1,293,344 | 0.01 | 0.08 | +0.06 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,866,400 | 2,866,733 | +1,000,333 | 0.54 | 0.87 | +0.33 | buy |
| Vestal Point Capital, LP | 1,075,000 | 1,700,069 | +625,069 | 1.39 | 2.20 | +0.81 | buy |
| Candriam S.C.A. | 0 | 248,610 | +248,610 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 2,110,167 | 2,341,667 | +231,500 | 7.82 | 5.80 | -2.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 190,334 | +190,334 | 0.00 | 0.72 | +0.72 | buy |
| Sio Capital Management, LLC | 0 | 116,997 | +116,997 | 0.00 | 0.64 | +0.64 | buy |
| Hudson Bay Capital Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 74,372 | +74,372 | 0.00 | 0.28 | +0.28 | buy |
| CITADEL ADVISORS LLC | 422,038 | 470,880 | +48,842 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 4,439,281 | 4,482,609 | +43,328 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,522 | 47,378 | +30,856 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 486,263 | 517,018 | +30,755 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 82,890 | 106,931 | +24,041 | 0.02 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 78,173 | 93,287 | +15,114 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 114,000 | 126,627 | +12,627 | 0.26 | 0.26 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 10,997 | +10,997 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 180,000 | 189,000 | +9,000 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 60,337 | 67,982 | +7,645 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,986 | +6,986 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 11,521 | 15,978 | +4,457 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 30,542 | 34,820 | +4,278 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 43,996 | 47,817 | +3,821 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 9,243 | 12,969 | +3,726 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 14,013 | 16,748 | +2,735 | 0.03 | 0.03 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,818 | 15,379 | +1,561 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 75 | 1,585 | +1,510 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 167,021 | 168,102 | +1,081 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,468 | 10,491 | +1,023 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 72,890 | 73,638 | +748 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,716 | 15,334 | +618 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 17,683 | 18,285 | +602 | 0.08 | 0.06 | -0.02 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 455 | +455 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 124 | 214 | +90 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 18 | 90 | +72 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 45 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,342 | 2,342 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.38 | 0.27 | -0.12 | hold |
| GREAT POINT PARTNERS LLC | 275,000 | 275,000 | 0 | 2.83 | 2.71 | -0.11 | hold |
| HighVista Strategies LLC | 31,387 | 31,387 | 0 | 0.25 | 0.22 | -0.04 | hold |
| Parkside Financial Bank & Trust | 385 | 385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Arax Advisory Partners | 32 | 32 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 1,744,373 | 1,744,373 | 0 | 2.61 | 2.69 | +0.08 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.26 | 0.24 | -0.02 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,689,707 | 2,689,707 | 0 | 6.90 | 7.22 | +0.32 | hold |
| Woodline Partners LP | 300,504 | 300,504 | 0 | 0.04 | 0.04 | -0.01 | hold |
| 5AM Venture Management, LLC | 1,027,711 | 1,027,711 | 0 | 5.35 | 7.05 | +1.70 | hold |
| Fairmount Funds Management LLC | 2,700,691 | 2,700,691 | 0 | 5.85 | 7.60 | +1.75 | hold |
| TCG Crossover Management, LLC | 1,501,624 | 1,501,624 | 0 | 3.20 | 3.72 | +0.52 | hold |
| Catalio Capital Management, LP | 763,471 | 763,471 | 0 | 3.64 | 3.43 | -0.21 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,765 | 5,765 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CROWLEY WEALTH MANAGEMENT, INC. | 221 | 221 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,700 | 9,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 827 | 827 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 7 | 1 | -6 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 9 | 0 | -9 | 0.00 | 0.00 | 0.00 | sell |
| Caitong International Asset Management Co., Ltd | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 11,081 | 10,985 | -96 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 11,883 | 11,709 | -174 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 23,932 | 23,684 | -248 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 14,372 | 14,093 | -279 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 711 | 384 | -327 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,026 | 12,680 | -346 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,379 | 1,003 | -376 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 12,129 | 11,683 | -446 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 35,933 | 35,045 | -888 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 1,200 | 0 | -1,200 | 0.03 | 0.00 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,695 | 1,358 | -1,337 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| KBC Group NV | 1,593 | 0 | -1,593 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 20,011 | 17,896 | -2,115 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 9,653 | 7,101 | -2,552 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,025 | 0 | -3,025 | 0.03 | 0.00 | -0.03 | sell |
| AlphaQuest LLC | 4,197 | 0 | -4,197 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 28,459 | 23,872 | -4,587 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 10,036 | 4,784 | -5,252 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,055 | 1,732 | -6,323 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 53,861 | 47,429 | -6,432 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 12,319 | 3,891 | -8,428 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 245,523 | 235,533 | -9,990 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 10,601 | 0 | -10,601 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 42,766 | 31,141 | -11,625 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 14,400 | 0 | -14,400 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 25,000 | 0 | -25,000 | 1.07 | 0.00 | -1.07 | sell |
| Ally Bridge Group (NY) LLC | 106,434 | 80,584 | -25,850 | 1.99 | 1.32 | -0.67 | sell |
| Cubist Systematic Strategies, LLC | 54,766 | 21,818 | -32,948 | 0.02 | 0.01 | -0.01 | sell |
| BlackRock, Inc. | 1,650,882 | 1,615,801 | -35,081 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 116,049 | 79,168 | -36,881 | 0.00 | 0.00 | -0.00 | sell |