| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,431,329 | 7,767,686 | +1,336,357 | 0.01 | 0.03 | +0.02 | buy |
| BlackRock, Inc. | 1,915,236 | 3,175,703 | +1,260,467 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,611,733 | 2,611,733 | +1,000,000 | 0.68 | 2.32 | +1.64 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,503,190 | 2,595,783 | +92,593 | 0.02 | 0.04 | +0.02 | buy |
| Fairmount Funds Management LLC | 2,137,191 | 2,537,191 | +400,000 | 6.70 | 15.38 | +8.68 | buy |
| Avidity Partners Management LP | 2,104,184 | 2,104,184 | 0 | 25.01 | 35.76 | +10.75 | hold |
| Octagon Capital Advisors LP | 2,416,667 | 1,946,667 | -470,000 | 12.47 | 18.08 | +5.61 | sell |
| TCG Crossover Management, LLC | 1,676,624 | 1,676,624 | 0 | 2.29 | 4.03 | +1.74 | hold |
| CITADEL ADVISORS LLC | 1,068,934 | 1,610,483 | +541,549 | 0.03 | 0.10 | +0.07 | buy |
| STATE STREET CORP | 1,507,619 | 1,398,913 | -108,706 | 0.00 | 0.00 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 1,292,182 | +1,292,182 | 0.00 | 0.07 | +0.07 | buy |
| VR Adviser, LLC | 1,000,000 | 1,180,000 | +180,000 | 2.04 | 3.70 | +1.66 | buy |
| FRED ALGER MANAGEMENT, LLC | 33,460 | 1,161,923 | +1,128,463 | 0.01 | 0.43 | +0.42 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616,033 | 1,146,948 | +530,915 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,004,728 | 1,076,009 | +71,281 | 0.19 | 0.39 | +0.21 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,019,813 | +1,019,813 | 0.00 | 1.01 | +1.01 | buy |
| FRANKLIN RESOURCES INC | 462,826 | 968,182 | +505,356 | 0.00 | 0.02 | +0.02 | buy |
| Cormorant Asset Management, LP | 0 | 950,000 | +950,000 | 0.00 | 4.02 | +4.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 834,383 | 926,071 | +91,688 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 676,658 | 916,211 | +239,553 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,273,935 | 899,364 | -374,571 | 1.68 | 2.52 | +0.84 | sell |
| BAKER BROS. ADVISORS LP | 789,759 | 852,164 | +62,405 | 0.19 | 0.41 | +0.22 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 836,000 | +836,000 | 0.00 | 0.42 | +0.42 | buy |
| UBS Group AG | 606,620 | 781,282 | +174,662 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 750,136 | 654,746 | -95,390 | 4.47 | 6.47 | +2.00 | sell |
| Point72 Asset Management, L.P. | 1,166,088 | 643,599 | -522,489 | 0.08 | 0.09 | +0.02 | sell |
| Catalio Capital Management, LP | 653,572 | 560,308 | -93,264 | 4.76 | 9.82 | +5.06 | sell |
| GOLDMAN SACHS GROUP INC | 577,019 | 548,010 | -29,009 | 0.00 | 0.01 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 485,136 | +485,136 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 474,085 | +474,085 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 213,087 | 433,457 | +220,370 | 0.03 | 0.14 | +0.10 | buy |
| SAMLYN CAPITAL, LLC | 0 | 431,115 | +431,115 | 0.00 | 0.62 | +0.62 | buy |
| AMERIPRISE FINANCIAL INC | 155,163 | 429,127 | +273,964 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 423,982 | +423,982 | 0.00 | 2.75 | +2.75 | buy |
| Logos Global Management LP | 315,000 | 400,000 | +85,000 | 0.87 | 1.73 | +0.86 | buy |
| Artisan Partners Limited Partnership | 0 | 382,121 | +382,121 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 176,300 | 379,606 | +203,306 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 474,503 | 370,045 | -104,458 | 3.24 | 4.48 | +1.23 | sell |
| Bain Capital Life Sciences Investors, LLC | 743,592 | 362,470 | -381,122 | 2.35 | 2.74 | +0.40 | sell |
| Vivo Capital, LLC | 353,998 | 353,998 | 0 | 0.94 | 2.47 | +1.53 | hold |
| Affinity Asset Advisors, LLC | 115,000 | 350,000 | +235,000 | 0.34 | 1.72 | +1.38 | buy |
| MARSHALL WACE, LLP | 1,008,533 | 341,929 | -666,604 | 0.04 | 0.03 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 210,673 | 325,440 | +114,767 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 317,312 | +317,312 | 0.00 | 0.20 | +0.20 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,812 | 305,440 | +54,628 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 207,246 | 303,752 | +96,506 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 299,210 | +299,210 | 0.00 | 0.08 | +0.08 | buy |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.54 | 1.13 | +0.59 | hold |
| MILLENNIUM MANAGEMENT LLC | 667,216 | 261,962 | -405,254 | 0.02 | 0.02 | -0.00 | sell |
| RTW INVESTMENTS, LP | 0 | 248,063 | +248,063 | 0.00 | 0.21 | +0.21 | buy |
| Freestone Grove Partners LP | 0 | 239,943 | +239,943 | 0.00 | 0.15 | +0.15 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 475,749 | 235,748 | -240,001 | 0.01 | 0.01 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 225,261 | +225,261 | 0.00 | 0.31 | +0.31 | buy |
| First Turn Management, LLC | 0 | 220,921 | +220,921 | 0.00 | 2.07 | +2.07 | buy |
| Nuveen, LLC | 190,615 | 217,482 | +26,867 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 311,150 | 213,522 | -97,628 | 0.06 | 0.09 | +0.03 | sell |
| Ensign Peak Advisors, Inc | 134,416 | 204,336 | +69,920 | 0.01 | 0.03 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 202,410 | +202,410 | 0.00 | 0.21 | +0.21 | buy |
| BANK OF AMERICA CORP /DE/ | 465,538 | 188,779 | -276,759 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 75,132 | 188,412 | +113,280 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 99,576 | 172,137 | +72,561 | 0.42 | 1.52 | +1.10 | buy |
| Artia Global Partners LP | 205,090 | 162,990 | -42,100 | 1.36 | 3.08 | +1.73 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 160,000 | +160,000 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 205,815 | 153,585 | -52,230 | 0.05 | 0.08 | +0.03 | sell |
| Integral Health Asset Management, LLC | 275,000 | 150,000 | -125,000 | 0.57 | 0.67 | +0.09 | sell |
| D. E. Shaw & Co., Inc. | 154,678 | 149,609 | -5,069 | 0.00 | 0.01 | +0.01 | sell |
| Tri Locum Partners LP | 622,403 | 145,543 | -476,860 | 3.33 | 1.71 | -1.62 | sell |
| Invesco Ltd. | 101,489 | 130,747 | +29,258 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 88,289 | 129,065 | +40,776 | 0.00 | 0.01 | +0.01 | buy |
| Atika Capital Management LLC | 134,528 | 128,800 | -5,728 | 0.77 | 1.71 | +0.93 | sell |
| TD ASSET MANAGEMENT INC | 31,750 | 116,576 | +84,826 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 116,444 | +116,444 | 0.00 | 0.09 | +0.09 | buy |
| Hudson Bay Capital Management LP | 0 | 109,238 | +109,238 | 0.00 | 0.06 | +0.06 | buy |
| Atom Investors LP | 181,860 | 107,753 | -74,107 | 0.60 | 0.65 | +0.05 | sell |
| SummitTX Capital, L.P. | 87,926 | 100,044 | +12,118 | 0.11 | 0.27 | +0.16 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.56 | +0.56 | buy |
| MORGAN STANLEY | 228,016 | 97,455 | -130,561 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 45,906 | 94,408 | +48,502 | 0.11 | 0.52 | +0.41 | buy |
| Patient Square Capital LP | 150,000 | 93,882 | -56,118 | 1.32 | 1.40 | +0.07 | sell |
| SEI INVESTMENTS CO | 13,841 | 92,229 | +78,388 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 246,788 | 85,530 | -161,258 | 0.11 | 0.07 | -0.04 | sell |
| STEMPOINT CAPITAL LP | 79,284 | 85,502 | +6,218 | 0.56 | 1.38 | +0.82 | buy |
| MOODY ALDRICH PARTNERS LLC | 41,304 | 82,129 | +40,825 | 0.32 | 1.24 | +0.93 | buy |
| Rhenman & Partners Asset Management AB | 98,627 | 81,627 | -17,000 | 0.38 | 0.85 | +0.47 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,466 | 80,001 | +28,535 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 72,767 | 79,096 | +6,329 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 84,636 | 76,640 | -7,996 | 0.39 | 0.74 | +0.35 | sell |
| Schonfeld Strategic Advisors LLC | 182,619 | 73,468 | -109,151 | 0.04 | 0.05 | +0.01 | sell |
| Swiss National Bank | 31,400 | 69,000 | +37,600 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 375,000 | 67,282 | -307,718 | 0.92 | 0.35 | -0.57 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,598 | 65,238 | +39,640 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,073 | 60,435 | +48,362 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 5,216 | 59,077 | +53,861 | 0.00 | 0.04 | +0.03 | buy |
| Neuberger Berman Group LLC | 87,782 | 59,076 | -28,706 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 55,000 | +55,000 | 0.00 | 0.28 | +0.28 | buy |
| Alyeska Investment Group, L.P. | 0 | 52,247 | +52,247 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 0 | 51,250 | +51,250 | 0.00 | 0.31 | +0.31 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.21 | +0.21 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,900 | 47,972 | +41,072 | 0.00 | 0.01 | +0.01 | buy |