| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,611,733 | 2,611,733 | +1,000,000 | 0.68 | 2.32 | +1.64 | buy |
| Fairmount Funds Management LLC | 2,137,191 | 2,537,191 | +400,000 | 6.70 | 15.38 | +8.68 | buy |
| Affinity Asset Advisors, LLC | 115,000 | 350,000 | +235,000 | 0.34 | 1.72 | +1.38 | buy |
| VR Adviser, LLC | 1,000,000 | 1,180,000 | +180,000 | 2.04 | 3.70 | +1.66 | buy |
| Logos Global Management LP | 315,000 | 400,000 | +85,000 | 0.87 | 1.73 | +0.86 | buy |
| PFM Health Sciences, LP | 99,576 | 172,137 | +72,561 | 0.42 | 1.52 | +1.10 | buy |
| Polar Capital Holdings Plc | 1,004,728 | 1,076,009 | +71,281 | 0.19 | 0.39 | +0.21 | buy |
| BAKER BROS. ADVISORS LP | 789,759 | 852,164 | +62,405 | 0.19 | 0.41 | +0.22 | buy |
| Cinctive Capital Management LP | 45,906 | 94,408 | +48,502 | 0.11 | 0.52 | +0.41 | buy |
| SummitTX Capital, L.P. | 87,926 | 100,044 | +12,118 | 0.11 | 0.27 | +0.16 | buy |
| ANTIPODES PARTNERS Ltd | 459 | 364 | -95 | 0.00 | 0.00 | +0.00 | sell |
| Shay Capital LLC | 11,000 | 9,500 | -1,500 | 0.07 | 0.11 | +0.04 | sell |
| RBF Capital, LLC | 5,000 | 3,000 | -2,000 | 0.01 | 0.01 | +0.00 | sell |
| BIT Capital GmbH | 15,000 | 12,000 | -3,000 | 0.03 | 0.06 | +0.03 | sell |
| Palumbo Wealth Management LLC | 14,967 | 10,360 | -4,607 | 0.15 | 0.21 | +0.06 | sell |
| Atika Capital Management LLC | 134,528 | 128,800 | -5,728 | 0.77 | 1.71 | +0.93 | sell |
| Informed Momentum Co LLC | 84,636 | 76,640 | -7,996 | 0.39 | 0.74 | +0.35 | sell |
| HighVista Strategies LLC | 48,484 | 35,587 | -12,897 | 0.51 | 0.82 | +0.31 | sell |
| Rhenman & Partners Asset Management AB | 98,627 | 81,627 | -17,000 | 0.38 | 0.85 | +0.47 | sell |
| Patient Square Capital LP | 150,000 | 93,882 | -56,118 | 1.32 | 1.40 | +0.07 | sell |
| Atom Investors LP | 181,860 | 107,753 | -74,107 | 0.60 | 0.65 | +0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 750,136 | 654,746 | -95,390 | 4.47 | 6.47 | +2.00 | sell |
| Candriam S.C.A. | 311,150 | 213,522 | -97,628 | 0.06 | 0.09 | +0.03 | sell |
| Sio Capital Management, LLC | 474,503 | 370,045 | -104,458 | 3.24 | 4.48 | +1.23 | sell |
| Integral Health Asset Management, LLC | 275,000 | 150,000 | -125,000 | 0.57 | 0.67 | +0.09 | sell |
| Nantahala Capital Management, LLC | 375,000 | 67,282 | -307,718 | 0.92 | 0.35 | -0.57 | sell |
| Bain Capital Life Sciences Investors, LLC | 743,592 | 362,470 | -381,122 | 2.35 | 2.74 | +0.40 | sell |
| Octagon Capital Advisors LP | 2,416,667 | 1,946,667 | -470,000 | 12.47 | 18.08 | +5.61 | sell |
| Tri Locum Partners LP | 622,403 | 145,543 | -476,860 | 3.33 | 1.71 | -1.62 | sell |