| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,431,329 | 7,767,686 | +1,336,357 | 0.01 | 0.03 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,292,182 | +1,292,182 | 0.00 | 0.07 | +0.07 | buy |
| BlackRock, Inc. | 1,915,236 | 3,175,703 | +1,260,467 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 33,460 | 1,161,923 | +1,128,463 | 0.01 | 0.43 | +0.42 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,019,813 | +1,019,813 | 0.00 | 1.01 | +1.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,611,733 | 2,611,733 | +1,000,000 | 0.68 | 2.32 | +1.64 | buy |
| Cormorant Asset Management, LP | 0 | 950,000 | +950,000 | 0.00 | 4.02 | +4.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 836,000 | +836,000 | 0.00 | 0.42 | +0.42 | buy |
| CITADEL ADVISORS LLC | 1,068,934 | 1,610,483 | +541,549 | 0.03 | 0.10 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 616,033 | 1,146,948 | +530,915 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 462,826 | 968,182 | +505,356 | 0.00 | 0.02 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 0 | 485,136 | +485,136 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 474,085 | +474,085 | 0.00 | 0.08 | +0.08 | buy |
| SAMLYN CAPITAL, LLC | 0 | 431,115 | +431,115 | 0.00 | 0.62 | +0.62 | buy |
| MPM BioImpact LLC | 0 | 423,982 | +423,982 | 0.00 | 2.75 | +2.75 | buy |
| Fairmount Funds Management LLC | 2,137,191 | 2,537,191 | +400,000 | 6.70 | 15.38 | +8.68 | buy |
| Artisan Partners Limited Partnership | 0 | 382,121 | +382,121 | 0.00 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 317,312 | +317,312 | 0.00 | 0.20 | +0.20 | buy |
| LORD, ABBETT & CO. LLC | 0 | 299,210 | +299,210 | 0.00 | 0.08 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 155,163 | 429,127 | +273,964 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 248,063 | +248,063 | 0.00 | 0.21 | +0.21 | buy |
| Freestone Grove Partners LP | 0 | 239,943 | +239,943 | 0.00 | 0.15 | +0.15 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 676,658 | 916,211 | +239,553 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 115,000 | 350,000 | +235,000 | 0.34 | 1.72 | +1.38 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 225,261 | +225,261 | 0.00 | 0.31 | +0.31 | buy |
| First Turn Management, LLC | 0 | 220,921 | +220,921 | 0.00 | 2.07 | +2.07 | buy |
| Woodline Partners LP | 213,087 | 433,457 | +220,370 | 0.03 | 0.14 | +0.10 | buy |
| BARCLAYS PLC | 176,300 | 379,606 | +203,306 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 202,410 | +202,410 | 0.00 | 0.21 | +0.21 | buy |
| VR Adviser, LLC | 1,000,000 | 1,180,000 | +180,000 | 2.04 | 3.70 | +1.66 | buy |
| UBS Group AG | 606,620 | 781,282 | +174,662 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 160,000 | +160,000 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 0 | 116,444 | +116,444 | 0.00 | 0.09 | +0.09 | buy |
| DIMENSIONAL FUND ADVISORS LP | 210,673 | 325,440 | +114,767 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 75,132 | 188,412 | +113,280 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 109,238 | +109,238 | 0.00 | 0.06 | +0.06 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.56 | +0.56 | buy |
| NORTHERN TRUST CORP | 207,246 | 303,752 | +96,506 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,503,190 | 2,595,783 | +92,593 | 0.02 | 0.04 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 834,383 | 926,071 | +91,688 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 315,000 | 400,000 | +85,000 | 0.87 | 1.73 | +0.86 | buy |
| TD ASSET MANAGEMENT INC | 31,750 | 116,576 | +84,826 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 13,841 | 92,229 | +78,388 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 99,576 | 172,137 | +72,561 | 0.42 | 1.52 | +1.10 | buy |
| Polar Capital Holdings Plc | 1,004,728 | 1,076,009 | +71,281 | 0.19 | 0.39 | +0.21 | buy |
| Ensign Peak Advisors, Inc | 134,416 | 204,336 | +69,920 | 0.01 | 0.03 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 789,759 | 852,164 | +62,405 | 0.19 | 0.41 | +0.22 | buy |
| ADAR1 Capital Management, LLC | 0 | 55,000 | +55,000 | 0.00 | 0.28 | +0.28 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,812 | 305,440 | +54,628 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 5,216 | 59,077 | +53,861 | 0.00 | 0.04 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 0 | 52,247 | +52,247 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 0 | 51,250 | +51,250 | 0.00 | 0.31 | +0.31 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.21 | +0.21 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| Cinctive Capital Management LP | 45,906 | 94,408 | +48,502 | 0.11 | 0.52 | +0.41 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,073 | 60,435 | +48,362 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,900 | 47,972 | +41,072 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 41,304 | 82,129 | +40,825 | 0.32 | 1.24 | +0.93 | buy |
| LPL Financial LLC | 0 | 40,824 | +40,824 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 88,289 | 129,065 | +40,776 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,598 | 65,238 | +39,640 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 31,400 | 69,000 | +37,600 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 35,045 | +35,045 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 10,800 | 41,087 | +30,287 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 101,489 | 130,747 | +29,258 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,466 | 80,001 | +28,535 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 190,615 | 217,482 | +26,867 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 26,757 | +26,757 | 0.00 | 0.13 | +0.13 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 25,875 | +25,875 | 0.00 | 0.02 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 5,379 | 31,184 | +25,805 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,887 | 40,584 | +24,697 | 0.00 | 0.00 | +0.00 | buy |
| SIG BROKERAGE, LP | 0 | 20,292 | +20,292 | 0.00 | 0.48 | +0.48 | buy |
| Qube Research & Technologies Ltd | 10,294 | 30,354 | +20,060 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 18,126 | +18,126 | 0.00 | 0.00 | +0.00 | buy |
| Darwin Global Management, Ltd. | 0 | 17,357 | +17,357 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 2,012 | 19,064 | +17,052 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,831 | 31,460 | +15,629 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 15,088 | +15,088 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 31,029 | 45,186 | +14,157 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 12,532 | +12,532 | 0.00 | 0.10 | +0.10 | buy |
| Lisanti Capital Growth, LLC | 0 | 12,410 | +12,410 | 0.00 | 0.26 | +0.26 | buy |
| SummitTX Capital, L.P. | 87,926 | 100,044 | +12,118 | 0.11 | 0.27 | +0.16 | buy |
| DIADEMA PARTNERS LP | 0 | 10,000 | +10,000 | 0.00 | 0.35 | +0.35 | buy |
| Arizona State Retirement System | 0 | 9,595 | +9,595 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 8,400 | 16,500 | +8,100 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 13,590 | 21,627 | +8,037 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF HAWAII | 0 | 7,904 | +7,904 | 0.00 | 0.03 | +0.03 | buy |
| J. Goldman & Co LP | 0 | 7,716 | +7,716 | 0.00 | 0.03 | +0.03 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 7,600 | +7,600 | 0.00 | 0.14 | +0.14 | buy |
| Polymer Capital Management (US) LLC | 0 | 7,339 | +7,339 | 0.00 | 0.09 | +0.09 | buy |
| AMERICAN CENTURY COMPANIES INC | 72,767 | 79,096 | +6,329 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 79,284 | 85,502 | +6,218 | 0.56 | 1.38 | +0.82 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 16,175 | 22,310 | +6,135 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 6,077 | +6,077 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,555 | 19,529 | +5,974 | 0.00 | 0.01 | +0.01 | buy |
| Fieldview Capital Management, LLC | 0 | 5,973 | +5,973 | 0.00 | 0.15 | +0.15 | buy |
| KLP KAPITALFORVALTNING AS | 3,400 | 8,900 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 5,443 | +5,443 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 5,197 | +5,197 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 5,100 | +5,100 | 0.00 | 1.04 | +1.04 | buy |