| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 537,828 | 1,245,228 | +707,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 74,400 | 498,920 | +424,520 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 20,398 | 407,706 | +387,308 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 366,851 | +366,851 | 0.00 | 0.30 | +0.30 | buy |
| Octagon Capital Advisors LP | 1,380,667 | 1,746,667 | +366,000 | 5.04 | 7.46 | +2.42 | buy |
| JANUS HENDERSON GROUP PLC | 375,044 | 675,664 | +300,620 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 0 | 250,333 | +250,333 | 0.00 | 0.06 | +0.06 | buy |
| FMR LLC | 4,161,045 | 4,402,420 | +241,375 | 0.01 | 0.01 | -0.00 | buy |
| Avidity Partners Management LP | 2,717,554 | 2,917,231 | +199,677 | 2.90 | 3.21 | +0.31 | buy |
| Vestal Point Capital, LP | 455,000 | 600,000 | +145,000 | 1.13 | 1.16 | +0.03 | buy |
| GREAT POINT PARTNERS LLC | 625,000 | 757,929 | +132,929 | 2.92 | 3.76 | +0.84 | buy |
| Bank of New York Mellon Corp | 8,426 | 80,935 | +72,509 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 68,567 | +68,567 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 18,491 | 54,689 | +36,198 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 32,138 | +32,138 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 10,345 | 39,504 | +29,159 | 0.08 | 0.21 | +0.13 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 25,010 | +25,010 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 23,389 | +23,389 | 0.00 | 0.11 | +0.11 | buy |
| ALPS ADVISORS INC | 0 | 22,915 | +22,915 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,992,028 | 3,013,423 | +21,395 | 7.21 | 8.56 | +1.35 | buy |
| Swiss National Bank | 0 | 17,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 12,900 | +12,900 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 0 | 11,135 | +11,135 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 10,319 | +10,319 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,238 | +10,238 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 10,152 | +10,152 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 9,711 | +9,711 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 9,700 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 9,469 | +9,469 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 9,102 | +9,102 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,959 | 30,432 | +8,473 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 8,116 | +8,116 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 8,054 | +8,054 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 6,085 | +6,085 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 4,333 | +4,333 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 3,358 | +3,358 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 15,495 | 18,374 | +2,879 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,342 | +2,342 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 827 | +827 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 10,784 | 10,784 | 0 | 0.02 | 0.02 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.83 | 0.70 | -0.13 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,333,000 | 2,333,000 | 0 | 0.89 | 0.80 | -0.09 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RTW INVESTMENTS, LP | 666,667 | 666,667 | 0 | 0.30 | 0.27 | -0.03 | hold |
| VR Adviser, LLC | 2,094,373 | 2,094,373 | 0 | 2.99 | 3.45 | +0.46 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.25 | 0.27 | +0.02 | hold |
| Fairmount Funds Management LLC | 2,762,837 | 2,762,837 | 0 | 9.03 | 8.08 | -0.96 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| EntryPoint Capital, LLC | 363 | 0 | -363 | 0.01 | 0.00 | -0.01 | sell |
| MACQUARIE GROUP LTD | 1,824 | 0 | -1,824 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 21,728 | 19,726 | -2,002 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 24,125 | 20,976 | -3,149 | 0.01 | 0.01 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,897 | 0 | -3,897 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 4,012 | 0 | -4,012 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 112,930 | 108,199 | -4,731 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 14,403 | 8,499 | -5,904 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 14,505 | 8,409 | -6,096 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 6,686 | 0 | -6,686 | 0.05 | 0.00 | -0.05 | sell |
| XTX Topco Ltd | 7,219 | 0 | -7,219 | 0.03 | 0.00 | -0.03 | sell |
| LMR Partners LLP | 7,478 | 0 | -7,478 | 0.01 | 0.00 | -0.01 | sell |
| Jefferies Financial Group Inc. | 7,600 | 0 | -7,600 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 7,786 | 0 | -7,786 | 0.01 | 0.00 | -0.01 | sell |
| 5AM Venture Management, LLC | 1,242,029 | 1,232,965 | -9,064 | 8.34 | 7.14 | -1.21 | sell |
| Y-Intercept (Hong Kong) Ltd | 12,090 | 0 | -12,090 | 0.03 | 0.00 | -0.03 | sell |
| Brevan Howard Capital Management LP | 12,253 | 0 | -12,253 | 0.03 | 0.00 | -0.03 | sell |
| Virtu Financial LLC | 12,995 | 0 | -12,995 | 0.03 | 0.00 | -0.03 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 13,371 | 0 | -13,371 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,642 | 0 | -13,642 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 13,942 | 0 | -13,942 | 0.01 | 0.00 | -0.01 | sell |
| Marathon Trading Investment Management LLC | 14,500 | 0 | -14,500 | 0.17 | 0.00 | -0.17 | sell |
| JPMORGAN CHASE & CO | 16,018 | 0 | -16,018 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 22,736 | 6,085 | -16,651 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 16,996 | 0 | -16,996 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 105,704 | 88,604 | -17,100 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 21,000 | 0 | -21,000 | 0.15 | 0.00 | -0.15 | sell |
| CITADEL ADVISORS LLC | 24,829 | 0 | -24,829 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 25,536 | 0 | -25,536 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 37,971 | 10,500 | -27,471 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 36,367 | 6,317 | -30,050 | 0.01 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 34,174 | 0 | -34,174 | 0.01 | 0.00 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 43,456 | 0 | -43,456 | 0.35 | 0.00 | -0.35 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 298,000 | 250,000 | -48,000 | 0.02 | 0.01 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 186,979 | 136,979 | -50,000 | 0.52 | 0.37 | -0.14 | sell |
| Qube Research & Technologies Ltd | 67,846 | 11,205 | -56,641 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 80,000 | 0 | -80,000 | 0.02 | 0.00 | -0.02 | sell |
| JANE STREET GROUP, LLC | 82,051 | 0 | -82,051 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 100,000 | 0 | -100,000 | 0.26 | 0.00 | -0.26 | sell |
| GOLDMAN SACHS GROUP INC | 170,217 | 41,869 | -128,348 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 352,100 | 174,200 | -177,900 | 0.03 | 0.01 | -0.02 | sell |
| Walleye Capital LLC | 190,266 | 0 | -190,266 | 0.06 | 0.00 | -0.06 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 205,487 | 0 | -205,487 | 0.01 | 0.00 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 216,968 | 0 | -216,968 | 3.62 | 0.00 | -3.62 | sell |
| MILLENNIUM MANAGEMENT LLC | 277,213 | 0 | -277,213 | 0.01 | 0.00 | -0.01 | sell |