| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,700,069 | 3,200,000 | +1,499,931 | 2.20 | 3.14 | +0.94 | buy |
| BAKER BROS. ADVISORS LP | 0 | 789,759 | +789,759 | 0.00 | 0.14 | +0.14 | buy |
| VANGUARD GROUP INC | 1,108,875 | 1,446,081 | +337,206 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 73,430 | 364,592 | +291,162 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 195,357 | +195,357 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 470,880 | 665,044 | +194,164 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 172,039 | +172,039 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,025,622 | 1,174,822 | +149,200 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 134,416 | +134,416 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 116,997 | 236,070 | +119,073 | 0.64 | 1.76 | +1.12 | buy |
| Woodline Partners LP | 300,504 | 400,504 | +100,000 | 0.04 | 0.04 | +0.00 | buy |
| UBS Group AG | 47,429 | 131,481 | +84,052 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 75,079 | +75,079 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 93,287 | 165,125 | +71,838 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,482,609 | 4,544,188 | +61,579 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 759,679 | 820,137 | +60,458 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 79,168 | 137,849 | +58,681 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 56,261 | +56,261 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,358 | 49,531 | +48,173 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 75,000 | 115,425 | +40,425 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 31,141 | 64,821 | +33,680 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 29,214 | +29,214 | 0.00 | 0.12 | +0.12 | buy |
| XTX Topco Ltd | 0 | 27,003 | +27,003 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 22,945 | +22,945 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,720,902 | 1,742,902 | +22,000 | 6.44 | 6.51 | +0.07 | buy |
| Cubist Systematic Strategies, LLC | 21,818 | 43,381 | +21,563 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 10,985 | 30,709 | +19,724 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 2,700,691 | 2,707,191 | +6,500 | 7.60 | 6.53 | -1.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 67,982 | 74,351 | +6,369 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 47,817 | 54,140 | +6,323 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,680 | 18,009 | +5,329 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 5,028 | +5,028 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 15,978 | 20,940 | +4,962 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 23,872 | 28,522 | +4,650 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,003 | 4,320 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 3,187 | +3,187 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 1,014 | +1,014 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 356 | +356 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,491 | 10,692 | +201 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 137 | +137 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,964 | +135 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 384 | 486 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 385 | 410 | +25 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,342 | 2,342 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 12,969 | 12,969 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.27 | 0.25 | -0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,866,733 | 2,866,733 | 0 | 0.87 | 0.90 | +0.03 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 14,093 | 14,093 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rhenman & Partners Asset Management AB | 126,627 | 126,627 | 0 | 0.26 | 0.30 | +0.03 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.24 | 0.18 | -0.06 | hold |
| Octagon Capital Advisors LP | 2,341,667 | 2,341,667 | 0 | 5.80 | 9.57 | +3.77 | hold |
| TCG Crossover Management, LLC | 1,501,624 | 1,501,624 | 0 | 3.72 | 3.20 | -0.52 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CROWLEY WEALTH MANAGEMENT, INC. | 221 | 221 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 827 | 827 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 111 | 106 | -5 | 0.00 | 0.00 | -0.00 | sell |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| TD PRIVATE CLIENT WEALTH LLC | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 27 | 8 | -19 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 45 | 15 | -30 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 90 | 50 | -40 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 214 | 126 | -88 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,585 | 1,441 | -144 | 0.00 | 0.00 | -0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 455 | 0 | -455 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,732 | 1,219 | -513 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 74,372 | 73,266 | -1,106 | 0.28 | 0.26 | -0.02 | sell |
| Police & Firemen's Retirement System of New Jersey | 5,765 | 4,230 | -1,535 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,891 | 1,829 | -2,062 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 6,986 | 4,875 | -2,111 | 0.03 | 0.03 | -0.00 | sell |
| JPMORGAN CHASE & CO | 11,683 | 9,378 | -2,305 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,379 | 12,326 | -3,053 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,334 | 12,091 | -3,243 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 17,896 | 14,488 | -3,408 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 35,045 | 31,501 | -3,544 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 168,102 | 164,313 | -3,789 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 189,000 | 185,000 | -4,000 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 4,784 | 0 | -4,784 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,700 | 4,100 | -5,600 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 23,684 | 17,366 | -6,318 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 73,638 | 66,712 | -6,926 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 7,101 | 0 | -7,101 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 16,748 | 8,913 | -7,835 | 0.03 | 0.01 | -0.02 | sell |
| Candriam S.C.A. | 248,610 | 240,576 | -8,034 | 0.03 | 0.03 | -0.00 | sell |
| HRT FINANCIAL LP | 10,997 | 0 | -10,997 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 11,709 | 0 | -11,709 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 31,387 | 15,861 | -15,526 | 0.22 | 0.11 | -0.11 | sell |
| Nuveen, LLC | 64,381 | 47,693 | -16,688 | 0.00 | 0.00 | -0.00 | sell |
| Catalio Capital Management, LP | 763,471 | 746,527 | -16,944 | 3.43 | 2.92 | -0.52 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,378 | 30,067 | -17,311 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 18,285 | 0 | -18,285 | 0.06 | 0.00 | -0.06 | sell |