| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,767,686 | 8,199,893 | +432,207 | 0.03 | 0.03 | +0.00 | buy |
| BlackRock, Inc. | 3,175,703 | 4,123,822 | +948,119 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,292,182 | 3,888,456 | +2,596,274 | 0.07 | 0.25 | +0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,595,783 | 3,229,882 | +634,099 | 0.04 | 0.05 | +0.01 | buy |
| Fairmount Funds Management LLC | 2,537,191 | 2,537,191 | 0 | 15.38 | 16.35 | +0.97 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,146,948 | 2,514,946 | +1,367,998 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,398,913 | 2,357,440 | +958,527 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 2,104,184 | 2,104,184 | 0 | 35.76 | 32.85 | -2.91 | hold |
| Octagon Capital Advisors LP | 1,946,667 | 1,841,667 | -105,000 | 18.08 | 16.48 | -1.60 | sell |
| TCG Crossover Management, LLC | 1,676,624 | 1,676,624 | 0 | 4.03 | 3.93 | -0.10 | hold |
| FRED ALGER MANAGEMENT, LLC | 1,161,923 | 1,302,493 | +140,570 | 0.43 | 0.42 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 916,211 | 1,258,502 | +342,291 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 1,180,000 | 1,180,000 | 0 | 3.70 | 3.49 | -0.21 | hold |
| UBS Group AG | 781,282 | 1,140,260 | +358,978 | 0.01 | 0.02 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,019,813 | 1,125,313 | +105,500 | 1.01 | 1.14 | +0.13 | buy |
| JENNISON ASSOCIATES LLC | 485,136 | 1,021,763 | +536,627 | 0.03 | 0.06 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,076,009 | 1,018,726 | -57,283 | 0.39 | 0.28 | -0.11 | sell |
| CITADEL ADVISORS LLC | 1,610,483 | 974,911 | -635,572 | 0.10 | 0.05 | -0.04 | sell |
| FRANKLIN RESOURCES INC | 968,182 | 968,983 | +801 | 0.02 | 0.02 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 852,164 | 852,164 | 0 | 0.41 | 0.42 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 926,071 | 834,150 | -91,921 | 0.01 | 0.02 | +0.01 | sell |
| Logos Global Management LP | 400,000 | 800,000 | +400,000 | 1.73 | 3.36 | +1.63 | buy |
| Cormorant Asset Management, LP | 950,000 | 750,000 | -200,000 | 4.02 | 3.75 | -0.27 | sell |
| BRAIDWELL LP | 899,364 | 594,562 | -304,802 | 2.52 | 2.14 | -0.37 | sell |
| AMERIPRISE FINANCIAL INC | 429,127 | 531,999 | +102,872 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 433,457 | 500,548 | +67,091 | 0.14 | 0.15 | +0.01 | buy |
| BARCLAYS PLC | 379,606 | 431,753 | +52,147 | 0.01 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 299,210 | 422,185 | +122,975 | 0.08 | 0.12 | +0.04 | buy |
| MPM BioImpact LLC | 423,982 | 420,002 | -3,980 | 2.75 | 2.50 | -0.25 | sell |
| NORTHERN TRUST CORP | 303,752 | 411,791 | +108,039 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 400,000 | +50,000 | 1.72 | 1.91 | +0.18 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 654,746 | 390,000 | -264,746 | 6.47 | 4.23 | -2.24 | sell |
| GOLDMAN SACHS GROUP INC | 548,010 | 382,161 | -165,849 | 0.01 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 365,963 | +365,963 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 305,440 | 365,963 | +60,523 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 362,470 | 362,470 | 0 | 2.74 | 2.10 | -0.64 | hold |
| Vivo Capital, LLC | 353,998 | 353,998 | 0 | 2.47 | 3.15 | +0.68 | hold |
| DIMENSIONAL FUND ADVISORS LP | 325,440 | 321,503 | -3,937 | 0.01 | 0.01 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 314,914 | +314,914 | 0.00 | 0.10 | +0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 317,312 | 295,266 | -22,046 | 0.20 | 0.17 | -0.03 | sell |
| First Turn Management, LLC | 220,921 | 285,771 | +64,850 | 2.07 | 2.98 | +0.91 | buy |
| Assenagon Asset Management S.A. | 0 | 280,649 | +280,649 | 0.00 | 0.04 | +0.04 | buy |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 1.13 | 1.17 | +0.04 | hold |
| Artisan Partners Limited Partnership | 382,121 | 258,269 | -123,852 | 0.05 | 0.04 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 188,779 | 256,833 | +68,054 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 188,412 | 256,393 | +67,981 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 248,063 | 248,063 | 0 | 0.21 | 0.21 | -0.00 | hold |
| EMERALD ADVISERS, LLC | 0 | 247,805 | +247,805 | 0.00 | 0.57 | +0.57 | buy |
| Pictet Asset Management Holding SA | 4,924 | 247,295 | +242,371 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 116,576 | 225,334 | +108,758 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 225,261 | 225,261 | 0 | 0.31 | 0.29 | -0.02 | hold |
| LMR Partners LLP | 116,444 | 223,995 | +107,551 | 0.09 | 0.16 | +0.07 | buy |
| Candriam S.C.A. | 213,522 | 204,214 | -9,308 | 0.09 | 0.09 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 85,502 | 200,851 | +115,349 | 1.38 | 3.39 | +2.01 | buy |
| Qube Research & Technologies Ltd | 30,354 | 196,924 | +166,570 | 0.00 | 0.02 | +0.02 | buy |
| SAMLYN CAPITAL, LLC | 431,115 | 196,326 | -234,789 | 0.62 | 0.32 | -0.30 | sell |
| Nicholas Investment Partners, LP | 51,250 | 186,769 | +135,519 | 0.31 | 1.03 | +0.71 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000 | 185,000 | +25,000 | 0.02 | 0.03 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 204,336 | 174,187 | -30,149 | 0.03 | 0.03 | -0.00 | sell |
| TimesSquare Capital Management, LLC | 0 | 166,357 | +166,357 | 0.00 | 0.24 | +0.24 | buy |
| Atika Capital Management LLC | 128,800 | 165,000 | +36,200 | 1.71 | 1.60 | -0.11 | buy |
| Artia Global Partners LP | 162,990 | 162,990 | 0 | 3.08 | 3.02 | -0.06 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 474,085 | 162,005 | -312,080 | 0.08 | 0.03 | -0.05 | sell |
| Neuberger Berman Group LLC | 59,076 | 157,574 | +98,498 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 52,247 | 150,592 | +98,345 | 0.01 | 0.04 | +0.03 | buy |
| Russell Investments Group, Ltd. | 129,065 | 143,341 | +14,276 | 0.01 | 0.01 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 131,344 | +131,344 | 0.00 | 2.12 | +2.12 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 131,018 | +131,018 | 0.00 | 0.45 | +0.45 | buy |
| MARSHALL WACE, LLP | 341,929 | 128,743 | -213,186 | 0.03 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 172,137 | 121,222 | -50,915 | 1.52 | 1.03 | -0.49 | sell |
| Tri Locum Partners LP | 145,543 | 120,712 | -24,831 | 1.71 | 1.45 | -0.27 | sell |
| Nuveen, LLC | 217,482 | 119,460 | -98,022 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 115,000 | +115,000 | 0.00 | 0.21 | +0.21 | buy |
| Patient Square Capital LP | 93,882 | 108,000 | +14,118 | 1.40 | 1.63 | +0.23 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 107,455 | +107,455 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 97,455 | 106,376 | +8,921 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 100,000 | 0 | 0.56 | 0.39 | -0.17 | hold |
| FIRST TRUST ADVISORS LP | 0 | 94,152 | +94,152 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 92,229 | 92,280 | +51 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 261,962 | 91,838 | -170,124 | 0.02 | 0.01 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 15,662 | 88,315 | +72,653 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 79,096 | 87,860 | +8,764 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 81,627 | 86,127 | +4,500 | 0.85 | 0.79 | -0.05 | buy |
| Invesco Ltd. | 130,747 | 85,603 | -45,144 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 60,435 | 75,396 | +14,961 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 82,129 | 74,552 | -7,577 | 1.24 | 1.31 | +0.06 | sell |
| Swiss National Bank | 69,000 | 73,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 31,460 | 69,756 | +38,296 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 65,683 | +65,683 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 40,824 | 65,295 | +24,471 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 100,044 | 63,866 | -36,178 | 0.27 | 0.16 | -0.10 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,238 | 62,829 | -2,409 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,972 | 60,048 | +12,076 | 0.01 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 370,045 | 59,254 | -310,791 | 4.48 | 0.99 | -3.49 | sell |
| RHUMBLINE ADVISERS | 45,186 | 58,521 | +13,335 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 25,875 | 57,042 | +31,167 | 0.02 | 0.05 | +0.03 | buy |
| CITIGROUP INC | 7,685 | 56,844 | +49,159 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 36,206 | 55,281 | +19,075 | 0.01 | 0.03 | +0.01 | buy |
| HighVista Strategies LLC | 35,587 | 51,125 | +15,538 | 0.82 | 1.14 | +0.31 | buy |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.21 | 0.18 | -0.03 | hold |