| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALLIANCEBERNSTEIN L.P. | 25,010 | 1,023,143 | +998,133 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 407,706 | 821,131 | +413,425 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 675,664 | 949,334 | +273,670 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 174,200 | 437,700 | +263,500 | 0.01 | 0.04 | +0.03 | buy |
| Rhenman & Partners Asset Management AB | 0 | 150,000 | +150,000 | 0.00 | 0.33 | +0.33 | buy |
| NORTHERN TRUST CORP | 54,689 | 202,600 | +147,911 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 366,851 | 493,687 | +126,836 | 0.30 | 0.38 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 0 | 118,738 | +118,738 | 0.00 | 0.54 | +0.54 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,567 | 165,929 | +97,362 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 18,374 | 88,031 | +69,657 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 67,285 | +67,285 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 59,301 | +59,301 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 53,785 | +53,785 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,245,228 | 1,294,969 | +49,741 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 41,869 | 80,606 | +38,737 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 34,754 | +34,754 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,499 | 41,684 | +33,185 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 30,647 | +30,647 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 20,976 | 50,248 | +29,272 | 0.01 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 28,931 | +28,931 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 20,316 | +20,316 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 8,409 | 28,428 | +20,019 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 19,808 | +19,808 | 0.00 | 0.19 | +0.19 | buy |
| Squarepoint Ops LLC | 0 | 15,163 | +15,163 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 14,364 | +14,364 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 30,432 | 42,367 | +11,935 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,319 | 22,089 | +11,770 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,085 | 17,394 | +11,309 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,639 | +10,639 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 8,656 | +8,656 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,085 | 13,939 | +7,854 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 7,821 | +7,821 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 4,333 | 8,839 | +4,506 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 9,469 | 12,832 | +3,363 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 6,317 | 9,633 | +3,316 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 3,141 | +3,141 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,112 | +3,112 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 32,138 | 34,617 | +2,479 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,323 | +2,323 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,054 | 9,956 | +1,902 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1 | 1,125 | +1,124 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,402,420 | 4,403,148 | +728 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,500 | 11,189 | +689 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 385 | +385 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 203 | +203 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 250,333 | 250,504 | +171 | 0.06 | 0.06 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,358 | 3,422 | +64 | 0.04 | 0.04 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 20 | +15 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,342 | 2,342 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 10,784 | 10,784 | 0 | 0.02 | 0.02 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.70 | 0.52 | -0.18 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,333,000 | 2,333,000 | 0 | 0.80 | 0.74 | -0.06 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RTW INVESTMENTS, LP | 666,667 | 666,667 | 0 | 0.27 | 0.26 | -0.00 | hold |
| Swiss National Bank | 17,300 | 17,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.27 | 0.31 | +0.04 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,013,423 | 3,013,423 | 0 | 8.56 | 8.58 | +0.02 | hold |
| Avidity Partners Management LP | 2,917,231 | 2,917,231 | 0 | 3.21 | 4.07 | +0.87 | hold |
| Octagon Capital Advisors LP | 1,746,667 | 1,746,667 | 0 | 7.46 | 7.66 | +0.20 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,700 | 9,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 827 | 827 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quarry LP | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 12,859 | 12,780 | -79 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 8,116 | 7,961 | -155 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,102 | 8,883 | -219 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,711 | 9,407 | -304 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 11,135 | 10,731 | -404 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 12,900 | 12,474 | -426 | 0.03 | 0.03 | -0.00 | sell |
| ALPS ADVISORS INC | 22,915 | 22,297 | -618 | 0.00 | 0.00 | +0.00 | sell |
| 5AM Venture Management, LLC | 1,232,965 | 1,231,619 | -1,346 | 7.14 | 6.97 | -0.17 | sell |
| Qube Research & Technologies Ltd | 11,205 | 7,753 | -3,452 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 80,935 | 73,015 | -7,920 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 10,152 | 0 | -10,152 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 10,238 | 0 | -10,238 | 0.02 | 0.00 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 498,920 | 485,121 | -13,799 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 19,726 | 0 | -19,726 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 23,389 | 0 | -23,389 | 0.11 | 0.00 | -0.11 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 39,504 | 8,568 | -30,936 | 0.21 | 0.04 | -0.17 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 88,604 | 55,416 | -33,188 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 108,199 | 53,848 | -54,351 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 136,979 | 76,979 | -60,000 | 0.37 | 0.20 | -0.18 | sell |
| Fairmount Funds Management LLC | 2,762,837 | 2,700,691 | -62,146 | 8.08 | 6.00 | -2.08 | sell |
| Vestal Point Capital, LP | 600,000 | 395,000 | -205,000 | 1.16 | 0.85 | -0.30 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000 | 0 | -250,000 | 0.01 | 0.00 | -0.01 | sell |
| VR Adviser, LLC | 2,094,373 | 1,744,373 | -350,000 | 3.45 | 2.50 | -0.95 | sell |
| GREAT POINT PARTNERS LLC | 757,929 | 275,000 | -482,929 | 3.76 | 2.27 | -1.49 | sell |