| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,544,188 | 5,970,638 | +1,426,450 | 0.00 | 0.01 | +0.01 | buy |
| Fairmount Funds Management LLC | 2,707,191 | 3,307,191 | +600,000 | 6.53 | 11.71 | +5.18 | buy |
| Avidity Partners Management LP | 1,742,902 | 3,204,184 | +1,461,282 | 6.51 | 28.70 | +22.19 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,866,733 | 2,866,733 | 0 | 0.90 | 1.39 | +0.49 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 74,351 | 2,577,662 | +2,503,311 | 0.00 | 0.02 | +0.02 | buy |
| Octagon Capital Advisors LP | 2,341,667 | 2,416,667 | +75,000 | 9.57 | 14.84 | +5.27 | buy |
| Point72 Asset Management, L.P. | 1,392,517 | 2,041,960 | +649,443 | 0.06 | 0.17 | +0.11 | buy |
| TCG Crossover Management, LLC | 1,501,624 | 1,676,624 | +175,000 | 3.20 | 3.25 | +0.05 | buy |
| VANGUARD GROUP INC | 1,446,081 | 1,642,198 | +196,117 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,358,781 | 1,340,091 | -18,690 | 0.00 | 0.00 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,482,250 | 1,315,892 | -1,166,358 | 5.79 | 3.44 | -2.35 | sell |
| Vestal Point Capital, LP | 3,200,000 | 1,180,000 | -2,020,000 | 3.14 | 2.11 | -1.03 | sell |
| CITADEL ADVISORS LLC | 665,044 | 1,013,501 | +348,457 | 0.01 | 0.03 | +0.02 | buy |
| VR Adviser, LLC | 1,000,000 | 960,803 | -39,197 | 1.40 | 2.13 | +0.73 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,174,822 | 852,384 | -322,438 | 0.01 | 0.01 | +0.00 | sell |
| BRAIDWELL LP | 0 | 835,057 | +835,057 | 0.00 | 0.97 | +0.97 | buy |
| BAKER BROS. ADVISORS LP | 789,759 | 789,759 | 0 | 0.14 | 0.22 | +0.08 | hold |
| Polar Capital Holdings Plc | 0 | 748,003 | +748,003 | 0.00 | 0.14 | +0.14 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 95,806 | 674,966 | +579,160 | 0.37 | 3.85 | +3.48 | buy |
| STATE STREET CORP | 820,137 | 671,048 | -149,089 | 0.00 | 0.00 | +0.00 | sell |
| Catalio Capital Management, LP | 746,527 | 667,615 | -78,912 | 2.92 | 4.86 | +1.94 | sell |
| Sio Capital Management, LLC | 236,070 | 577,750 | +341,680 | 1.76 | 5.75 | +3.99 | buy |
| MARSHALL WACE, LLP | 0 | 572,938 | +572,938 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 484,900 | 536,415 | +51,515 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 450,311 | +450,311 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 443,703 | +443,703 | 0.00 | 0.04 | +0.04 | buy |
| Nantahala Capital Management, LLC | 0 | 375,000 | +375,000 | 0.00 | 0.91 | +0.91 | buy |
| 5AM Venture Management, LLC | 984,725 | 365,053 | -619,672 | 7.05 | 5.26 | -1.79 | sell |
| Vivo Capital, LLC | 0 | 353,998 | +353,998 | 0.00 | 1.12 | +1.12 | buy |
| Ikarian Capital, LLC | 0 | 346,001 | +346,001 | 0.00 | 2.75 | +2.75 | buy |
| Candriam S.C.A. | 240,576 | 301,428 | +60,852 | 0.03 | 0.06 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 0 | 265,803 | +265,803 | 0.00 | 4.37 | +4.37 | buy |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.25 | 0.40 | +0.15 | hold |
| Affinity Asset Advisors, LLC | 0 | 262,100 | +262,100 | 0.00 | 0.96 | +0.96 | buy |
| GOLDMAN SACHS GROUP INC | 364,592 | 218,771 | -145,821 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,692 | 216,135 | +205,443 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.18 | 0.34 | +0.16 | hold |
| BARCLAYS PLC | 64,821 | 204,369 | +139,548 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 200,000 | +200,000 | 0.00 | 0.78 | +0.78 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 164,313 | 193,059 | +28,746 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 182,867 | +182,867 | 0.00 | 1.65 | +1.65 | buy |
| BANK OF AMERICA CORP /DE/ | 165,125 | 180,025 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 126,627 | 173,627 | +47,000 | 0.30 | 0.76 | +0.46 | buy |
| NORTHERN TRUST CORP | 160,315 | 157,531 | -2,784 | 0.00 | 0.00 | +0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.43 | +0.43 | buy |
| MILLENNIUM MANAGEMENT LLC | 195,357 | 146,166 | -49,191 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 26,133 | 141,129 | +114,996 | 0.00 | 0.05 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 138,963 | +138,963 | 0.00 | 0.14 | +0.14 | buy |
| Caption Management, LLC | 0 | 138,561 | +138,561 | 0.00 | 0.32 | +0.32 | buy |
| UBS Group AG | 131,481 | 137,073 | +5,592 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 134,416 | 134,416 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 172,039 | 128,253 | -43,786 | 0.02 | 0.04 | +0.01 | sell |
| Patient Square Capital LP | 0 | 125,000 | +125,000 | 0.00 | 1.32 | +1.32 | buy |
| Artia Global Partners LP | 0 | 108,723 | +108,723 | 0.00 | 0.75 | +0.75 | buy |
| AMERIPRISE FINANCIAL INC | 56,261 | 103,755 | +47,494 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 86,337 | +86,337 | 0.00 | 0.38 | +0.38 | buy |
| MORGAN STANLEY | 137,849 | 77,520 | -60,329 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 185,000 | 77,000 | -108,000 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 11,670 | 68,479 | +56,809 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,378 | 68,124 | +58,746 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 67,840 | +67,840 | 0.00 | 0.23 | +0.23 | buy |
| Bank of New York Mellon Corp | 66,712 | 62,430 | -4,282 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 54,140 | 62,321 | +8,181 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 61,038 | +61,038 | 0.00 | 0.18 | +0.18 | buy |
| HighVista Strategies LLC | 15,861 | 54,225 | +38,364 | 0.11 | 0.52 | +0.41 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 45,304 | +45,304 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 20,940 | 44,929 | +23,989 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 73,266 | 43,291 | -29,975 | 0.26 | 0.32 | +0.06 | sell |
| Nuveen, LLC | 47,693 | 43,241 | -4,452 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 400,504 | 42,698 | -357,806 | 0.04 | 0.01 | -0.03 | sell |
| STEMPOINT CAPITAL LP | 0 | 41,382 | +41,382 | 0.00 | 0.33 | +0.33 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,221 | +121 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 49,531 | 34,593 | -14,938 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 31,614 | +31,614 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 27,658 | +27,658 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 31,501 | 26,003 | -5,498 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 25,000 | +25,000 | 0.00 | 1.02 | +1.02 | buy |
| Longaeva Partners L.P. | 0 | 25,000 | +25,000 | 0.00 | 0.21 | +0.21 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 21,868 | +21,868 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Engineers Gate Manager LP | 0 | 20,379 | +20,379 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 18,782 | +18,782 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,568 | +18,568 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 28,522 | 17,331 | -11,191 | 0.00 | 0.00 | +0.00 | sell |
| BESSEMER GROUP INC | 14,964 | 16,134 | +1,170 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 15,875 | +15,875 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 15,734 | +15,734 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 17,366 | 15,631 | -1,735 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 14,488 | 14,488 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 0 | 14,275 | +14,275 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 13,939 | +13,939 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 12,326 | 12,383 | +57 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,067 | 12,061 | -18,006 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 11,930 | +11,930 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 11,245 | +11,245 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 11,124 | +11,124 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 14,093 | 9,613 | -4,480 | 0.00 | 0.00 | +0.00 | sell |
| SCS Capital Management LLC | 0 | 9,375 | +9,375 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 8,689 | +8,689 | 0.00 | 0.00 | +0.00 | buy |