| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 480,000 | 554,000 | +74,000 | 1.16 | 0.92 | -0.23 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 40,841 | +40,841 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 33,964 | +33,964 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 28,679 | +28,679 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 126,877 | 153,646 | +26,769 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 26,341 | 45,179 | +18,838 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 15,301 | +15,301 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 14,736 | +14,736 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 35,216 | 49,306 | +14,090 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 3,868 | 17,407 | +13,539 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,430 | +2,430 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 3 | 802 | +799 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 927,706 | 927,706 | 0 | 1.33 | 0.66 | -0.67 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.18 | 0.10 | -0.08 | hold |
| Avidity Partners Management LP | 1,217,554 | 1,217,554 | 0 | 0.67 | 0.48 | -0.19 | hold |
| 5AM Venture Management, LLC | 1,472,264 | 1,472,264 | 0 | 5.79 | 4.06 | -1.73 | hold |
| Fairmount Funds Management LLC | 1,928,503 | 1,928,503 | 0 | 3.17 | 2.12 | -1.05 | hold |
| Atlas Venture Life Science Advisors, LLC | 236,979 | 236,979 | 0 | 0.50 | 0.29 | -0.21 | hold |
| FMR LLC | 2,218,212 | 2,218,212 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Jefferies Financial Group Inc. | 13,200 | 13,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 22,299 | 17,888 | -4,411 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 15,676 | 10,784 | -4,892 | 0.01 | 0.01 | -0.01 | sell |
| Nantahala Capital Management, LLC | 336,862 | 328,433 | -8,429 | 0.58 | 0.34 | -0.24 | sell |
| Laurion Capital Management LP | 36,393 | 26,267 | -10,126 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 591,636 | 504,242 | -87,394 | 1.14 | 0.48 | -0.66 | sell |
| CITADEL ADVISORS LLC | 105,561 | 0 | -105,561 | 0.00 | 0.00 | -0.00 | sell |