| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 1,501,624 | +1,501,624 | 0.00 | 3.20 | +3.20 | buy |
| BRAIDWELL LP | 493,687 | 1,206,589 | +712,902 | 0.38 | 0.78 | +0.40 | buy |
| Vestal Point Capital, LP | 395,000 | 1,075,000 | +680,000 | 0.85 | 1.39 | +0.54 | buy |
| Octagon Capital Advisors LP | 1,746,667 | 2,110,167 | +363,500 | 7.66 | 7.82 | +0.17 | buy |
| CITADEL ADVISORS LLC | 59,301 | 422,038 | +362,737 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 180,000 | +180,000 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,023,143 | 1,159,776 | +136,633 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 949,334 | 1,085,648 | +136,314 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 80,606 | 208,067 | +127,461 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 106,434 | +106,434 | 0.00 | 1.99 | +1.99 | buy |
| MILLENNIUM MANAGEMENT LLC | 34,754 | 90,436 | +55,682 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 30,000 | 82,890 | +52,890 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 250,504 | 300,504 | +50,000 | 0.06 | 0.04 | -0.01 | buy |
| MORGAN STANLEY | 67,285 | 116,049 | +48,764 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 202,600 | 245,523 | +42,923 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,403,148 | 4,439,281 | +36,133 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 28,428 | 53,861 | +25,433 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,522 | +16,522 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17,394 | 30,542 | +13,148 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 19,808 | 31,387 | +11,579 | 0.19 | 0.25 | +0.07 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 9,243 | +9,243 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 12,832 | 20,011 | +7,179 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 53,785 | 60,337 | +6,552 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 1,644,819 | 1,650,882 | +6,063 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 50,248 | 54,766 | +4,518 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,656 | 13,026 | +4,370 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,125 | 4,197 | +3,072 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,695 | +2,695 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,956 | 12,319 | +2,363 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,821 | 9,468 | +1,647 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 22,297 | 23,932 | +1,635 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 42,367 | 43,996 | +1,629 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 0 | 1,593 | +1,593 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 12,474 | 14,013 | +1,539 | 0.03 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 10,639 | 12,129 | +1,490 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 34,617 | 35,933 | +1,316 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 485,121 | 486,263 | +1,142 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 165,929 | 167,021 | +1,092 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 41,684 | 42,766 | +1,082 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 8,839 | 9,653 | +814 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 10,731 | 11,521 | +790 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 78 | 711 | +633 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,939 | 14,372 | +433 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,364 | 14,716 | +352 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 6 | 124 | +118 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 65 | 75 | +10 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 5 | 9 | +4 | 0.00 | 0.00 | 0.00 | buy |
| BESSEMER GROUP INC | 14,829 | 14,829 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,342 | 2,342 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.52 | 0.38 | -0.14 | hold |
| GREAT POINT PARTNERS LLC | 275,000 | 275,000 | 0 | 2.27 | 2.83 | +0.55 | hold |
| Parkside Financial Bank & Trust | 385 | 385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RTW INVESTMENTS, LP | 666,667 | 666,667 | 0 | 0.26 | 0.22 | -0.04 | hold |
| VR Adviser, LLC | 1,744,373 | 1,744,373 | 0 | 2.50 | 2.61 | +0.11 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 208,697 | 208,697 | 0 | 0.31 | 0.26 | -0.05 | hold |
| Fairmount Funds Management LLC | 2,700,691 | 2,700,691 | 0 | 6.00 | 5.85 | -0.14 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,100 | 37,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,700 | 9,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 827 | 827 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 20 | 10 | -10 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 73 | 18 | -55 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 73,015 | 72,890 | -125 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 203 | 0 | -203 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,422 | 3,025 | -397 | 0.04 | 0.03 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 11,189 | 10,601 | -588 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 12,780 | 11,883 | -897 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,323 | 1,379 | -944 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,407 | 8,055 | -1,352 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 30,647 | 28,459 | -2,188 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 821,131 | 818,843 | -2,288 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 17,300 | 14,400 | -2,900 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 3,112 | 0 | -3,112 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 3,141 | 0 | -3,141 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,163 | 11,081 | -4,082 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 7,753 | 0 | -7,753 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 7,961 | 0 | -7,961 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 22,089 | 13,818 | -8,271 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 8,568 | 0 | -8,568 | 0.04 | 0.00 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,883 | 0 | -8,883 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 9,633 | 0 | -9,633 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 88,031 | 78,173 | -9,858 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 10,784 | 0 | -10,784 | 0.02 | 0.00 | -0.02 | sell |
| ROYAL BANK OF CANADA | 28,931 | 10,036 | -18,895 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 20,316 | 0 | -20,316 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,294,969 | 1,274,638 | -20,331 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 150,000 | 114,000 | -36,000 | 0.33 | 0.26 | -0.08 | sell |
| Avidity Partners Management LP | 2,917,231 | 2,873,000 | -44,231 | 4.07 | 6.24 | +2.17 | sell |
| MARSHALL WACE, LLP | 53,848 | 0 | -53,848 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 55,416 | 0 | -55,416 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 76,979 | 0 | -76,979 | 0.20 | 0.00 | -0.20 | sell |
| ADAR1 Capital Management, LLC | 118,738 | 17,683 | -101,055 | 0.54 | 0.08 | -0.47 | sell |
| 5AM Venture Management, LLC | 1,231,619 | 1,027,711 | -203,908 | 6.97 | 5.35 | -1.62 | sell |
| Point72 Asset Management, L.P. | 437,700 | 193,600 | -244,100 | 0.04 | 0.01 | -0.03 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,013,423 | 2,689,707 | -323,716 | 8.58 | 6.90 | -1.69 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,333,000 | 1,866,400 | -466,600 | 0.74 | 0.54 | -0.19 | sell |