| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Tri Locum Partners LP | 182,867 | 622,403 | +439,536 | 1.65 | 3.33 | +1.68 | buy |
| BRAIDWELL LP | 835,057 | 1,273,935 | +438,878 | 0.97 | 1.68 | +0.70 | buy |
| Polar Capital Holdings Plc | 748,003 | 1,004,728 | +256,725 | 0.14 | 0.19 | +0.05 | buy |
| Integral Health Asset Management, LLC | 150,000 | 275,000 | +125,000 | 0.43 | 0.57 | +0.14 | buy |
| Atom Investors LP | 61,038 | 181,860 | +120,822 | 0.18 | 0.60 | +0.41 | buy |
| Logos Global Management LP | 200,000 | 315,000 | +115,000 | 0.78 | 0.87 | +0.09 | buy |
| Artia Global Partners LP | 108,723 | 205,090 | +96,367 | 0.75 | 1.36 | +0.61 | buy |
| GREAT POINT PARTNERS LLC | 265,803 | 350,000 | +84,197 | 4.31 | 4.68 | +0.36 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 674,966 | 750,136 | +75,170 | 3.85 | 4.47 | +0.63 | buy |
| VR Adviser, LLC | 960,803 | 1,000,000 | +39,197 | 2.13 | 2.04 | -0.09 | buy |
| STEMPOINT CAPITAL LP | 41,382 | 79,284 | +37,902 | 0.33 | 0.56 | +0.23 | buy |
| PFM Health Sciences, LP | 67,840 | 99,576 | +31,736 | 0.21 | 0.41 | +0.20 | buy |
| Patient Square Capital LP | 125,000 | 150,000 | +25,000 | 1.32 | 1.32 | +0.01 | buy |
| Candriam S.C.A. | 301,428 | 311,150 | +9,722 | 0.06 | 0.06 | +0.00 | buy |
| Palumbo Wealth Management LLC | 6,650 | 14,967 | +8,317 | 0.08 | 0.15 | +0.07 | buy |
| Virtus Investment Advisers, LLC | 5,899 | 6,315 | +416 | 0.07 | 0.07 | +0.00 | buy |
| Informed Momentum Co LLC | 86,337 | 84,636 | -1,701 | 0.38 | 0.39 | +0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 43,291 | 41,304 | -1,987 | 0.32 | 0.32 | -0.01 | sell |
| RBF Capital, LLC | 7,000 | 5,000 | -2,000 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 54,225 | 48,484 | -5,741 | 0.52 | 0.51 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 25,000 | 16,708 | -8,292 | 1.02 | 0.47 | -0.55 | sell |
| FRED ALGER MANAGEMENT, LLC | 45,304 | 33,460 | -11,844 | 0.01 | 0.01 | -0.00 | sell |
| Catalio Capital Management, LP | 667,615 | 653,572 | -14,043 | 4.86 | 4.76 | -0.10 | sell |
| Rhenman & Partners Asset Management AB | 173,627 | 98,627 | -75,000 | 0.76 | 0.38 | -0.38 | sell |
| Sio Capital Management, LLC | 577,750 | 474,503 | -103,247 | 5.75 | 3.08 | -2.68 | sell |
| Affinity Asset Advisors, LLC | 262,100 | 115,000 | -147,100 | 0.96 | 0.34 | -0.62 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,315,892 | 743,592 | -572,300 | 3.44 | 2.35 | -1.09 | sell |
| Avidity Partners Management LP | 3,204,184 | 2,104,184 | -1,100,000 | 28.70 | 25.01 | -3.68 | sell |
| Fairmount Funds Management LLC | 3,307,191 | 2,137,191 | -1,170,000 | 11.71 | 6.70 | -5.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,866,733 | 1,611,733 | -1,255,000 | 1.39 | 0.68 | -0.71 | sell |