| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 671,048 | 1,507,619 | +836,571 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,340,091 | 1,915,236 | +575,145 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 146,166 | 667,216 | +521,050 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 137,073 | 606,620 | +469,547 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,970,638 | 6,431,329 | +460,691 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 34,593 | 475,749 | +441,156 | 0.00 | 0.01 | +0.01 | buy |
| Tri Locum Partners LP | 182,867 | 622,403 | +439,536 | 1.65 | 3.33 | +1.68 | buy |
| BRAIDWELL LP | 835,057 | 1,273,935 | +438,878 | 0.97 | 1.68 | +0.70 | buy |
| MARSHALL WACE, LLP | 572,938 | 1,008,533 | +435,595 | 0.02 | 0.04 | +0.02 | buy |
| VANGUARD GROUP INC | 1,642,198 | 2,048,452 | +406,254 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 216,135 | 616,033 | +399,898 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 218,771 | 577,019 | +358,248 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 180,025 | 465,538 | +285,513 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 748,003 | 1,004,728 | +256,725 | 0.14 | 0.19 | +0.05 | buy |
| ExodusPoint Capital Management, LP | 0 | 246,788 | +246,788 | 0.00 | 0.11 | +0.11 | buy |
| Iron Triangle Partners LP | 0 | 230,730 | +230,730 | 0.00 | 1.09 | +1.09 | buy |
| Squarepoint Ops LLC | 0 | 207,119 | +207,119 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 8,689 | 210,673 | +201,984 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 42,698 | 213,087 | +170,389 | 0.01 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 77,520 | 228,016 | +150,496 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 43,241 | 190,615 | +147,374 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 536,415 | 676,658 | +140,243 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 134,528 | +134,528 | 0.00 | 0.77 | +0.77 | buy |
| ALGERT GLOBAL LLC | 0 | 130,326 | +130,326 | 0.00 | 0.08 | +0.08 | buy |
| Integral Health Asset Management, LLC | 150,000 | 275,000 | +125,000 | 0.43 | 0.57 | +0.14 | buy |
| D. E. Shaw & Co., Inc. | 31,614 | 154,678 | +123,064 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 61,038 | 181,860 | +120,822 | 0.18 | 0.60 | +0.41 | buy |
| Logos Global Management LP | 200,000 | 315,000 | +115,000 | 0.78 | 0.87 | +0.09 | buy |
| Artia Global Partners LP | 108,723 | 205,090 | +96,367 | 0.75 | 1.36 | +0.61 | buy |
| SummitTX Capital, L.P. | 0 | 87,926 | +87,926 | 0.00 | 0.11 | +0.11 | buy |
| Neuberger Berman Group LLC | 0 | 87,782 | +87,782 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,618 | 88,289 | +86,671 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 265,803 | 350,000 | +84,197 | 4.37 | 4.68 | +0.31 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 674,966 | 750,136 | +75,170 | 3.85 | 4.47 | +0.63 | buy |
| Walleye Capital LLC | 141,129 | 205,815 | +64,686 | 0.05 | 0.05 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 193,059 | 250,812 | +57,753 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 44,929 | 101,489 | +56,560 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,013,501 | 1,068,934 | +55,433 | 0.03 | 0.03 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 128,253 | 182,619 | +54,366 | 0.04 | 0.04 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 103,755 | 155,163 | +51,408 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 157,531 | 207,246 | +49,715 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 48,477 | +48,477 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 48,400 | +48,400 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 45,906 | +45,906 | 0.00 | 0.11 | +0.11 | buy |
| JANE STREET GROUP, LLC | 0 | 45,833 | +45,833 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 17,331 | 57,875 | +40,544 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 11,930 | 51,700 | +39,770 | 0.01 | 0.04 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,061 | 51,466 | +39,405 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 960,803 | 1,000,000 | +39,197 | 2.13 | 2.04 | -0.09 | buy |
| STEMPOINT CAPITAL LP | 41,382 | 79,284 | +37,902 | 0.33 | 0.56 | +0.23 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 32,100 | +32,100 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 67,840 | 99,576 | +31,736 | 0.23 | 0.42 | +0.19 | buy |
| Swiss National Bank | 0 | 31,400 | +31,400 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 26,249 | +26,249 | 0.00 | 0.58 | +0.58 | buy |
| Patient Square Capital LP | 125,000 | 150,000 | +25,000 | 1.32 | 1.32 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,405 | 32,039 | +23,634 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,340 | +21,340 | 0.00 | 0.03 | +0.03 | buy |
| Lighthouse Investment Partners, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 15,631 | 35,206 | +19,575 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 18,565 | +18,565 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 21,868 | 39,480 | +17,612 | 0.00 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 16,829 | +16,829 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 12,383 | 28,968 | +16,585 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 14,790 | +14,790 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,220 | 15,887 | +14,667 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 13,948 | +13,948 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,342 | +13,342 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 62,430 | 75,132 | +12,702 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 11,124 | 23,694 | +12,570 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 450,311 | 462,826 | +12,515 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,497 | 13,590 | +12,093 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 12,073 | +12,073 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 6,313 | 17,333 | +11,020 | 0.01 | 0.02 | +0.01 | buy |
| Shay Capital LLC | 0 | 11,000 | +11,000 | 0.00 | 0.07 | +0.07 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,510 | +10,510 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 62,321 | 72,767 | +10,446 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 10,294 | +10,294 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 9,739 | +9,739 | 0.00 | 0.19 | +0.19 | buy |
| Candriam S.C.A. | 301,428 | 311,150 | +9,722 | 0.06 | 0.06 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 9,715 | +9,715 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 7,248 | 16,175 | +8,927 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 8,400 | +8,400 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 6,650 | 14,967 | +8,317 | 0.08 | 0.15 | +0.07 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 7,008 | +7,008 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,782 | 25,598 | +6,816 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 6,001 | +6,001 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 5,216 | +5,216 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,003 | 31,029 | +5,026 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 27,658 | 31,750 | +4,092 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 9,613 | 13,555 | +3,942 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,276 | +3,276 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 20,379 | 23,380 | +3,001 | 0.01 | 0.01 | +0.00 | buy |
| Quarry LP | 0 | 2,400 | +2,400 | 0.00 | 0.02 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 15,875 | 17,925 | +2,050 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 2,012 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,716 | 6,538 | +1,822 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,488 | 15,831 | +1,343 | 0.00 | 0.00 | +0.00 | buy |