| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,970,638 | 6,431,329 | +460,691 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,577,662 | 2,503,190 | -74,472 | 0.02 | 0.02 | +0.00 | sell |
| Octagon Capital Advisors LP | 2,416,667 | 2,416,667 | 0 | 14.84 | 12.47 | -2.38 | hold |
| Fairmount Funds Management LLC | 3,307,191 | 2,137,191 | -1,170,000 | 11.71 | 6.70 | -5.01 | sell |
| Avidity Partners Management LP | 3,204,184 | 2,104,184 | -1,100,000 | 28.70 | 25.01 | -3.68 | sell |
| VANGUARD GROUP INC | 1,642,198 | 2,048,452 | +406,254 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,340,091 | 1,915,236 | +575,145 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,676,624 | 1,676,624 | 0 | 3.25 | 2.29 | -0.96 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,866,733 | 1,611,733 | -1,255,000 | 1.39 | 0.68 | -0.71 | sell |
| STATE STREET CORP | 671,048 | 1,507,619 | +836,571 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 835,057 | 1,273,935 | +438,878 | 0.97 | 1.68 | +0.70 | buy |
| Point72 Asset Management, L.P. | 2,041,960 | 1,166,088 | -875,872 | 0.17 | 0.08 | -0.10 | sell |
| CITADEL ADVISORS LLC | 1,013,501 | 1,068,934 | +55,433 | 0.03 | 0.03 | -0.00 | buy |
| MARSHALL WACE, LLP | 572,938 | 1,008,533 | +435,595 | 0.02 | 0.04 | +0.02 | buy |
| Polar Capital Holdings Plc | 748,003 | 1,004,728 | +256,725 | 0.14 | 0.19 | +0.05 | buy |
| VR Adviser, LLC | 960,803 | 1,000,000 | +39,197 | 2.13 | 2.04 | -0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 852,384 | 834,383 | -18,001 | 0.01 | 0.01 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 789,759 | 789,759 | 0 | 0.22 | 0.19 | -0.03 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 674,966 | 750,136 | +75,170 | 3.85 | 4.47 | +0.63 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,315,892 | 743,592 | -572,300 | 3.44 | 2.35 | -1.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 536,415 | 676,658 | +140,243 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 146,166 | 667,216 | +521,050 | 0.00 | 0.02 | +0.02 | buy |
| Catalio Capital Management, LP | 667,615 | 653,572 | -14,043 | 4.86 | 4.76 | -0.10 | sell |
| Tri Locum Partners LP | 182,867 | 622,403 | +439,536 | 1.65 | 3.33 | +1.68 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 216,135 | 616,033 | +399,898 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 137,073 | 606,620 | +469,547 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 218,771 | 577,019 | +358,248 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 34,593 | 475,749 | +441,156 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 577,750 | 474,503 | -103,247 | 5.75 | 3.24 | -2.51 | sell |
| BANK OF AMERICA CORP /DE/ | 180,025 | 465,538 | +285,513 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 450,311 | 462,826 | +12,515 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 375,000 | 375,000 | 0 | 0.91 | 0.92 | +0.01 | hold |
| Vivo Capital, LLC | 353,998 | 353,998 | 0 | 1.12 | 0.94 | -0.18 | hold |
| GREAT POINT PARTNERS LLC | 265,803 | 350,000 | +84,197 | 4.37 | 4.68 | +0.31 | buy |
| Logos Global Management LP | 200,000 | 315,000 | +115,000 | 0.78 | 0.87 | +0.09 | buy |
| Candriam S.C.A. | 301,428 | 311,150 | +9,722 | 0.06 | 0.06 | +0.00 | buy |
| Integral Health Asset Management, LLC | 150,000 | 275,000 | +125,000 | 0.43 | 0.57 | +0.14 | buy |
| TANG CAPITAL MANAGEMENT LLC | 264,692 | 264,692 | 0 | 0.40 | 0.54 | +0.14 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 193,059 | 250,812 | +57,753 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 246,788 | +246,788 | 0.00 | 0.11 | +0.11 | buy |
| Iron Triangle Partners LP | 0 | 230,730 | +230,730 | 0.00 | 1.09 | +1.09 | buy |
| MORGAN STANLEY | 77,520 | 228,016 | +150,496 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 42,698 | 213,087 | +170,389 | 0.01 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 8,689 | 210,673 | +201,984 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 157,531 | 207,246 | +49,715 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 207,119 | +207,119 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 141,129 | 205,815 | +64,686 | 0.05 | 0.05 | +0.00 | buy |
| Artia Global Partners LP | 108,723 | 205,090 | +96,367 | 0.75 | 1.36 | +0.61 | buy |
| Nuveen, LLC | 43,241 | 190,615 | +147,374 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 128,253 | 182,619 | +54,366 | 0.04 | 0.04 | +0.00 | buy |
| Atom Investors LP | 61,038 | 181,860 | +120,822 | 0.18 | 0.60 | +0.41 | buy |
| BARCLAYS PLC | 204,369 | 176,300 | -28,069 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 103,755 | 155,163 | +51,408 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 31,614 | 154,678 | +123,064 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 125,000 | 150,000 | +25,000 | 1.32 | 1.32 | +0.01 | buy |
| Atika Capital Management LLC | 0 | 134,528 | +134,528 | 0.00 | 0.77 | +0.77 | buy |
| Ensign Peak Advisors, Inc | 134,416 | 134,416 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALGERT GLOBAL LLC | 0 | 130,326 | +130,326 | 0.00 | 0.08 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 262,100 | 115,000 | -147,100 | 0.96 | 0.34 | -0.62 | sell |
| Invesco Ltd. | 44,929 | 101,489 | +56,560 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 67,840 | 99,576 | +31,736 | 0.23 | 0.42 | +0.19 | buy |
| Rhenman & Partners Asset Management AB | 173,627 | 98,627 | -75,000 | 0.76 | 0.38 | -0.38 | sell |
| Russell Investments Group, Ltd. | 1,618 | 88,289 | +86,671 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 87,926 | +87,926 | 0.00 | 0.11 | +0.11 | buy |
| Neuberger Berman Group LLC | 0 | 87,782 | +87,782 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 86,337 | 84,636 | -1,701 | 0.38 | 0.39 | +0.01 | sell |
| STEMPOINT CAPITAL LP | 41,382 | 79,284 | +37,902 | 0.33 | 0.56 | +0.23 | buy |
| Bank of New York Mellon Corp | 62,430 | 75,132 | +12,702 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 62,321 | 72,767 | +10,446 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 17,331 | 57,875 | +40,544 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 11,930 | 51,700 | +39,770 | 0.01 | 0.04 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,061 | 51,466 | +39,405 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 54,225 | 48,484 | -5,741 | 0.52 | 0.51 | -0.01 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 48,477 | +48,477 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 48,400 | +48,400 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 45,906 | +45,906 | 0.00 | 0.11 | +0.11 | buy |
| JANE STREET GROUP, LLC | 0 | 45,833 | +45,833 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 68,124 | 42,639 | -25,485 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 43,291 | 41,304 | -1,987 | 0.32 | 0.32 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 21,868 | 39,480 | +17,612 | 0.00 | 0.01 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 37,221 | 37,221 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALPS ADVISORS INC | 15,631 | 35,206 | +19,575 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 45,304 | 33,460 | -11,844 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 32,100 | +32,100 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,405 | 32,039 | +23,634 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 27,658 | 31,750 | +4,092 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 31,400 | +31,400 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,003 | 31,029 | +5,026 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,383 | 28,968 | +16,585 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 26,249 | +26,249 | 0.00 | 0.58 | +0.58 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,782 | 25,598 | +6,816 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 11,124 | 23,694 | +12,570 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 20,379 | 23,380 | +3,001 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,340 | +21,340 | 0.00 | 0.03 | +0.03 | buy |
| ArrowMark Colorado Holdings LLC | 20,788 | 20,788 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Lighthouse Investment Partners, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 0 | 18,565 | +18,565 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 15,875 | 17,925 | +2,050 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 6,313 | 17,333 | +11,020 | 0.01 | 0.02 | +0.01 | buy |