| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 0 | 1,438,070 | +1,438,070 | 0.00 | 2.45 | +2.45 | buy |
| Nantahala Capital Management, LLC | 675,000 | 1,052,894 | +377,894 | 0.90 | 1.62 | +0.72 | buy |
| Nan Fung Group Holdings Ltd | 300,000 | 630,657 | +330,657 | 5.98 | 12.82 | +6.85 | buy |
| GREAT POINT PARTNERS LLC | 0 | 300,000 | +300,000 | 0.00 | 1.81 | +1.81 | buy |
| STATE STREET CORP | 250,030 | 504,373 | +254,343 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,238,934 | 2,470,845 | +231,911 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 675,000 | 863,947 | +188,947 | 0.04 | 0.06 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 136,966 | +136,966 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 100,198 | +100,198 | 0.00 | 0.16 | +0.16 | buy |
| TCG Crossover Management, LLC | 1,745,015 | 1,839,489 | +94,474 | 1.29 | 1.30 | +0.01 | buy |
| UBS Group AG | 50,713 | 137,932 | +87,219 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 441,454 | 518,228 | +76,774 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,525 | 72,067 | +70,542 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 65,429 | +65,429 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 303,115 | 363,799 | +60,684 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 52,640 | +52,640 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 100,000 | 150,000 | +50,000 | 0.11 | 0.20 | +0.08 | buy |
| STEMPOINT CAPITAL LP | 0 | 50,000 | +50,000 | 0.00 | 0.24 | +0.24 | buy |
| HighVista Strategies LLC | 140,107 | 173,595 | +33,488 | 0.80 | 1.18 | +0.38 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 896,806 | 923,694 | +26,888 | 0.04 | 0.04 | +0.01 | buy |
| Calamos Advisors LLC | 0 | 24,063 | +24,063 | 0.00 | 0.00 | +0.00 | buy |
| MEYER HANDELMAN CO | 0 | 15,094 | +15,094 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 0 | 14,506 | +14,506 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 143,966 | 154,398 | +10,432 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 9,931 | +9,931 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 407,668 | 416,906 | +9,238 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,616 | 186,095 | +8,479 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,100 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 435 | 5,569 | +5,134 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 40,517 | 45,457 | +4,940 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,074 | 13,229 | +2,155 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,298 | 15,359 | +2,061 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 3,400 | 5,100 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,425 | 6,041 | +1,616 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 16,283 | 17,103 | +820 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 221,865 | 222,508 | +643 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,361 | 1,661 | +300 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,966 | 9,170 | +204 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 14 | 162 | +148 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,007 | 4,052 | +45 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,562 | 1,562 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 12,720 | 12,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 200,000 | 200,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,208,604 | 2,208,604 | 0 | 0.50 | 0.58 | +0.07 | hold |
| MetLife Investment Management, LLC | 11,104 | 11,104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 800,000 | 800,000 | 0 | 1.15 | 1.64 | +0.49 | hold |
| Soleus Capital Management, L.P. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Commodore Capital LP | 1,500,000 | 1,500,000 | 0 | 2.22 | 2.14 | -0.08 | hold |
| Deep Track Capital, LP | 3,352,804 | 3,352,804 | 0 | 1.70 | 1.71 | +0.00 | hold |
| Nuveen, LLC | 22,966 | 22,966 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Boxer Capital Management, LLC | 70,000 | 70,000 | 0 | 0.34 | 0.23 | -0.11 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,184 | 1,041 | -143 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 1,878 | 1,723 | -155 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 592 | 368 | -224 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 10,955 | 10,729 | -226 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 20,095 | 19,815 | -280 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 605 | 0 | -605 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 30,000 | 28,919 | -1,081 | 0.45 | 0.51 | +0.05 | sell |
| Persistent Asset Partners Ltd | 4,080 | 0 | -4,080 | 0.04 | 0.00 | -0.04 | sell |
| SG Americas Securities, LLC | 6,434 | 0 | -6,434 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 12,445 | 0 | -12,445 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 22,303 | 8,623 | -13,680 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 18,014 | 0 | -18,014 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 19,121 | 0 | -19,121 | 0.01 | 0.00 | -0.01 | sell |
| NORGES BANK | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 30,215 | 4,530 | -25,685 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 43,758 | 16,618 | -27,140 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 31,733 | 0 | -31,733 | 0.00 | 0.00 | -0.00 | sell |
| Longbow Finance SA | 82,336 | 0 | -82,336 | 0.31 | 0.00 | -0.31 | sell |
| AMERIPRISE FINANCIAL INC | 193,544 | 108,307 | -85,237 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,611,482 | 1,427,568 | -183,914 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 821,852 | 538,216 | -283,636 | 0.01 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 1,200,000 | 915,000 | -285,000 | 1.78 | 1.16 | -0.62 | sell |