| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 3,352,804 | +3,352,804 | 0.00 | 1.48 | +1.48 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,776,958 | +1,776,958 | 0.00 | 0.35 | +0.35 | buy |
| TCG Crossover Management, LLC | 0 | 1,745,016 | +1,745,016 | 0.00 | 1.36 | +1.36 | buy |
| Commodore Capital LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 1.16 | +1.16 | buy |
| Logos Global Management LP | 0 | 1,130,000 | +1,130,000 | 0.00 | 1.76 | +1.76 | buy |
| JPMORGAN CHASE & CO | 0 | 1,032,603 | +1,032,603 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 975,000 | +975,000 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 968,274 | +968,274 | 0.00 | 0.03 | +0.03 | buy |
| Vivo Capital, LLC | 0 | 800,000 | +800,000 | 0.00 | 1.02 | +1.02 | buy |
| JENNISON ASSOCIATES LLC | 0 | 739,040 | +739,040 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 675,000 | +675,000 | 0.00 | 0.03 | +0.03 | buy |
| Nantahala Capital Management, LLC | 0 | 675,000 | +675,000 | 0.00 | 0.66 | +0.66 | buy |
| CITADEL ADVISORS LLC | 0 | 539,370 | +539,370 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 538,169 | +538,169 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 400,000 | +400,000 | 0.00 | 0.34 | +0.34 | buy |
| FMR LLC | 0 | 369,100 | +369,100 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 344,657 | +344,657 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 343,523 | +343,523 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 0 | 300,000 | +300,000 | 0.00 | 7.95 | +7.95 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 282,644 | +282,644 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 255,526 | +255,526 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 200,000 | +200,000 | 0.00 | 0.02 | +0.02 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.12 | +0.12 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 77,450 | +77,450 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.16 | +0.16 | buy |
| Boxer Capital Management, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.35 | +0.35 | buy |
| HRT FINANCIAL LP | 0 | 58,815 | +58,815 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.31 | +0.31 | buy |
| TD ASSET MANAGEMENT INC | 0 | 36,780 | +36,780 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 34,003 | +34,003 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 0 | 30,839 | +30,839 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 30,345 | +30,345 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.49 | +0.49 | buy |
| Hudson Bay Capital Management LP | 0 | 27,097 | +27,097 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,825 | +20,825 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 17,763 | +17,763 | 0.00 | 0.09 | +0.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 17,488 | +17,488 | 0.00 | 0.00 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 15,270 | +15,270 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 14,535 | +14,535 | 0.00 | 0.04 | +0.04 | buy |
| Quantessence Capital LLC | 0 | 14,225 | +14,225 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 13,591 | +13,591 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,500 | +13,500 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 13,259 | +13,259 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 13,100 | +13,100 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,276 | +11,276 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 10,638 | +10,638 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 9,000 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |