| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 975,000 | 2,238,934 | +1,263,934 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 1,112,978 | +1,112,978 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,032,603 | 1,611,482 | +578,879 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,776,958 | 2,208,604 | +431,646 | 0.35 | 0.50 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,591 | 441,454 | +427,863 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 250,030 | +250,030 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 177,616 | +177,616 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 143,966 | +143,966 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 140,107 | +140,107 | 0.00 | 0.80 | +0.80 | buy |
| AMERIPRISE FINANCIAL INC | 77,450 | 193,544 | +116,094 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 739,040 | 821,852 | +82,812 | 0.01 | 0.01 | +0.00 | buy |
| Longbow Finance SA | 0 | 82,336 | +82,336 | 0.00 | 0.31 | +0.31 | buy |
| Logos Global Management LP | 1,130,000 | 1,200,000 | +70,000 | 1.76 | 1.78 | +0.02 | buy |
| UBS Group AG | 0 | 50,713 | +50,713 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 43,758 | +43,758 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 40,517 | +40,517 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 22,966 | +22,966 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 22,303 | +22,303 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 20,095 | +20,095 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 16,283 | +16,283 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 13,298 | +13,298 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 11,104 | +11,104 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 10,955 | +10,955 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 8,966 | +8,966 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,276 | 19,121 | +7,845 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 6,434 | +6,434 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 4,425 | +4,425 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 4,080 | +4,080 | 0.00 | 0.04 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,007 | +4,007 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,878 | +1,878 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,562 | +1,562 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,525 | +1,525 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 30,345 | 31,733 | +1,388 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,361 | +1,361 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,184 | +1,184 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 605 | +605 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 592 | +592 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 435 | +435 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 200,000 | 200,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 675,000 | 675,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Nantahala Capital Management, LLC | 675,000 | 675,000 | 0 | 0.66 | 0.90 | +0.24 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 30,000 | 30,000 | 0 | 0.49 | 0.45 | -0.04 | hold |
| Vivo Capital, LLC | 800,000 | 800,000 | 0 | 1.02 | 1.15 | +0.13 | hold |
| Integral Health Asset Management, LLC | 100,000 | 100,000 | 0 | 0.12 | 0.11 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 300,000 | 300,000 | 0 | 7.95 | 5.98 | -1.97 | hold |
| Commodore Capital LP | 1,500,000 | 1,500,000 | 0 | 1.16 | 2.22 | +1.07 | hold |
| Deep Track Capital, LP | 3,352,804 | 3,352,804 | 0 | 1.48 | 1.70 | +0.23 | hold |
| Boxer Capital Management, LLC | 70,000 | 70,000 | 0 | 0.35 | 0.34 | -0.01 | hold |
| TCG Crossover Management, LLC | 1,745,016 | 1,745,015 | -1 | 1.36 | 1.29 | -0.07 | sell |
| Quarry LP | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 30,839 | 30,215 | -624 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 13,100 | 12,445 | -655 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,500 | 12,720 | -780 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 9,000 | 5,000 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,638 | 0 | -10,638 | 0.01 | 0.00 | -0.01 | sell |
| Brevan Howard Capital Management LP | 13,259 | 0 | -13,259 | 0.00 | 0.00 | -0.00 | sell |
| Quantessence Capital LLC | 14,225 | 0 | -14,225 | 0.07 | 0.00 | -0.07 | sell |
| ARISTEIA CAPITAL, L.L.C. | 15,270 | 0 | -15,270 | 0.01 | 0.00 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,488 | 0 | -17,488 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 17,763 | 0 | -17,763 | 0.09 | 0.00 | -0.09 | sell |
| Squarepoint Ops LLC | 20,825 | 0 | -20,825 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 27,097 | 0 | -27,097 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 36,780 | 0 | -36,780 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 40,000 | 0 | -40,000 | 0.31 | 0.00 | -0.31 | sell |
| GOLDMAN SACHS GROUP INC | 343,523 | 303,115 | -40,408 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 58,815 | 0 | -58,815 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 70,000 | 0 | -70,000 | 0.16 | 0.00 | -0.16 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 968,274 | 896,806 | -71,468 | 0.03 | 0.04 | +0.01 | sell |
| CITADEL ADVISORS LLC | 539,370 | 407,668 | -131,702 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 369,100 | 221,865 | -147,235 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 0 | -200,000 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 255,526 | 18,014 | -237,512 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 282,644 | 11,074 | -271,570 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 344,657 | 0 | -344,657 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 400,000 | 10,000 | -390,000 | 0.34 | 0.01 | -0.33 | sell |
| MILLENNIUM MANAGEMENT LLC | 538,169 | 0 | -538,169 | 0.01 | 0.00 | -0.01 | sell |