| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,673,855 | 5,504,506 | +1,830,651 | 0.19 | 0.27 | +0.08 | buy |
| T. Rowe Price Investment Management, Inc. | 1,182,121 | 2,115,486 | +933,365 | 0.29 | 0.51 | +0.22 | buy |
| JANUS HENDERSON GROUP PLC | 1,776,759 | 2,216,648 | +439,889 | 0.40 | 0.48 | +0.07 | buy |
| Clearbridge Investments, LLC | 436,797 | 596,277 | +159,480 | 0.14 | 0.19 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 138,651 | 273,556 | +134,905 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 3,021 | 135,099 | +132,078 | 0.02 | 1.07 | +1.06 | buy |
| Paradigm Biocapital Advisors LP | 422,577 | 552,120 | +129,543 | 7.53 | 7.65 | +0.12 | buy |
| Sofinnova Investments, Inc. | 44,721 | 149,300 | +104,579 | 0.95 | 3.47 | +2.52 | buy |
| AMERICAN CENTURY COMPANIES INC | 155,681 | 255,826 | +100,145 | 0.04 | 0.06 | +0.02 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 76,729 | +76,729 | 0.00 | 1.44 | +1.44 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 53,700 | 121,900 | +68,200 | 0.93 | 2.02 | +1.09 | buy |
| ORBIMED ADVISORS LLC | 84,600 | 151,600 | +67,000 | 0.64 | 1.10 | +0.45 | buy |
| BRAIDWELL LP | 153,204 | 219,824 | +66,620 | 2.14 | 2.79 | +0.65 | buy |
| Finepoint Capital LP | 0 | 50,000 | +50,000 | 0.00 | 5.05 | +5.05 | buy |
| Vestal Point Capital, LP | 0 | 50,000 | +50,000 | 0.00 | 1.63 | +1.63 | buy |
| Iron Triangle Partners LP | 0 | 45,000 | +45,000 | 0.00 | 1.83 | +1.83 | buy |
| MORGAN STANLEY | 652,887 | 693,880 | +40,993 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 0 | 38,153 | +38,153 | 0.00 | 0.10 | +0.10 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 30,000 | +30,000 | 0.00 | 0.27 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 193,885 | 223,695 | +29,810 | 0.07 | 0.08 | +0.01 | buy |
| Russell Investments Group, Ltd. | 25 | 29,673 | +29,648 | 0.00 | 0.02 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 79,777 | 104,724 | +24,947 | 0.03 | 0.04 | +0.01 | buy |
| Trexquant Investment LP | 0 | 24,895 | +24,895 | 0.00 | 0.20 | +0.20 | buy |
| Ensign Peak Advisors, Inc | 23,939 | 45,909 | +21,970 | 0.02 | 0.03 | +0.01 | buy |
| Pictet Asset Management Holding SA | 313,221 | 329,168 | +15,947 | 0.13 | 0.14 | +0.01 | buy |
| Artisan Partners Limited Partnership | 3,174,477 | 3,189,600 | +15,123 | 1.90 | 1.83 | -0.07 | buy |
| Saturn V Capital Management LP | 51,175 | 65,597 | +14,422 | 7.45 | 10.35 | +2.90 | buy |
| NATIXIS ADVISORS, LLC | 14,490 | 28,246 | +13,756 | 0.01 | 0.03 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,401 | +12,401 | 0.00 | 0.04 | +0.04 | buy |
| Checkpoint Capital L.P. | 70,000 | 82,000 | +12,000 | 18.58 | 21.58 | +2.99 | buy |
| Aberdeen Group plc | 73,476 | 85,431 | +11,955 | 0.06 | 0.07 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 10,536 | +10,536 | 0.00 | 0.05 | +0.05 | buy |
| Aquatic Capital Management LLC | 0 | 10,440 | +10,440 | 0.00 | 0.13 | +0.13 | buy |
| ExodusPoint Capital Management, LP | 4,330 | 13,886 | +9,556 | 0.02 | 0.07 | +0.05 | buy |
| Squarepoint Ops LLC | 18,400 | 27,874 | +9,474 | 0.03 | 0.05 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 111,048 | 119,019 | +7,971 | 0.08 | 0.06 | -0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 47,900 | 55,354 | +7,454 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,583 | 54,387 | +6,804 | 0.01 | 0.02 | +0.01 | buy |
| HighVista Strategies LLC | 1,067 | 6,745 | +5,678 | 0.15 | 0.95 | +0.80 | buy |
| WELLS FARGO & COMPANY/MN | 42,335 | 47,621 | +5,286 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,460 | 43,650 | +5,190 | 0.01 | 0.01 | +0.00 | buy |
| FORA Capital, LLC | 0 | 5,141 | +5,141 | 0.00 | 0.17 | +0.17 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | 30,000 | +5,000 | 0.23 | 0.24 | +0.01 | buy |
| Varma Mutual Pension Insurance Co | 0 | 5,000 | +5,000 | 0.00 | 0.02 | +0.02 | buy |
| BIT Capital GmbH | 0 | 4,694 | +4,694 | 0.00 | 0.16 | +0.16 | buy |
| Qube Research & Technologies Ltd | 7,990 | 12,387 | +4,397 | 0.01 | 0.01 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 46,146 | 50,335 | +4,189 | 0.03 | 0.03 | -0.00 | buy |
| Avoro Capital Advisors LLC | 1,234,567 | 1,238,467 | +3,900 | 6.49 | 5.69 | -0.80 | buy |
| Tri Locum Partners LP | 24,182 | 27,981 | +3,799 | 4.52 | 3.82 | -0.70 | buy |
| NORDEN GROUP LLC | 0 | 3,720 | +3,720 | 0.00 | 0.11 | +0.11 | buy |
| PineBridge Investments, L.P. | 22,576 | 25,836 | +3,260 | 0.08 | 0.08 | +0.00 | buy |
| NORTHERN TRUST CORP | 31,340 | 34,227 | +2,887 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 78,302 | 81,092 | +2,790 | 0.01 | 0.01 | -0.00 | buy |
| USS Investment Management Ltd | 12,417 | 15,144 | +2,727 | 0.04 | 0.05 | +0.01 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 2,252 | +2,252 | 0.00 | 0.41 | +0.41 | buy |
| China Universal Asset Management Co., Ltd. | 3,719 | 5,954 | +2,235 | 0.28 | 0.30 | +0.02 | buy |
| Cerity Partners LLC | 1,026 | 3,142 | +2,116 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 8,625 | 10,720 | +2,095 | 0.62 | 0.73 | +0.11 | buy |
| Jump Financial, LLC | 0 | 2,037 | +2,037 | 0.00 | 0.02 | +0.02 | buy |
| Polymer Capital Management (HK) LTD | 6,250 | 8,000 | +1,750 | 0.83 | 0.79 | -0.04 | buy |
| Cynosure Group, LLC | 0 | 1,709 | +1,709 | 0.00 | 0.12 | +0.12 | buy |
| GUGGENHEIM CAPITAL LLC | 4,662 | 6,179 | +1,517 | 0.01 | 0.02 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 4,890 | 6,339 | +1,449 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 1,657 | 3,078 | +1,421 | 0.00 | 0.00 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 0 | 1,291 | +1,291 | 0.00 | 0.05 | +0.05 | buy |
| Cinctive Capital Management LP | 1,195 | 2,482 | +1,287 | 0.03 | 0.05 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL LONDON ASSET MANAGEMENT LTD | 46,333 | 47,527 | +1,194 | 0.05 | 0.05 | -0.00 | buy |
| Amundi | 2,390 | 3,563 | +1,173 | 0.00 | 0.00 | +0.00 | buy |
| Maryland State Retirement & Pension System | 1,928 | 3,093 | +1,165 | 0.02 | 0.02 | +0.01 | buy |
| NEOS Investment Management LLC | 1,352 | 2,431 | +1,079 | 0.05 | 0.06 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,087 | 2,126 | +1,039 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 1,008 | +1,008 | 0.00 | 0.10 | +0.10 | buy |
| Cetera Investment Advisers | 1,955 | 2,869 | +914 | 0.01 | 0.00 | -0.00 | buy |
| ALTFEST L J & CO INC | 0 | 779 | +779 | 0.00 | 0.04 | +0.04 | buy |
| OLD MISSION CAPITAL LLC | 0 | 777 | +777 | 0.00 | 0.01 | +0.01 | buy |
| Handelsbanken Fonder AB | 25,853 | 26,621 | +768 | 0.05 | 0.05 | -0.00 | buy |
| ASSETMARK, INC | 5,638 | 6,397 | +759 | 0.01 | 0.01 | +0.00 | buy |
| CI INVESTMENTS INC. | 778 | 1,516 | +738 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 4,538 | 5,184 | +646 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 2,441 | 3,054 | +613 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ALLIANCE, LLC | 0 | 599 | +599 | 0.00 | 0.03 | +0.03 | buy |
| US BANCORP \DE\ | 3,271 | 3,782 | +511 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 25,023 | 25,531 | +508 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 2,786 | 3,198 | +412 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 1,209 | 1,614 | +405 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 1,099 | 1,460 | +361 | 0.01 | 0.01 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 1,428 | 1,772 | +344 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 4,690 | 5,031 | +341 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 25,912 | 26,228 | +316 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 1,035 | 1,351 | +316 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 5,227 | 5,507 | +280 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 328 | 588 | +260 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,340 | 1,575 | +235 | 0.00 | 0.00 | +0.00 | buy |
| Envestnet Portfolio Solutions, Inc. | 1,070 | 1,300 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 9,107 | 9,335 | +228 | 0.04 | 0.04 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 1,863 | 2,089 | +226 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,161 | 1,377 | +216 | 0.00 | 0.00 | +0.00 | buy |
| PARK AVENUE SECURITIES LLC | 1,023 | 1,235 | +212 | 0.01 | 0.01 | +0.00 | buy |
| State of Wyoming | 0 | 200 | +200 | 0.00 | 0.01 | +0.01 | buy |