| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 64,424 | 268,604 | +204,180 | 0.03 | 0.15 | +0.12 | buy |
| Capital World Investors | 1,786,936 | 1,937,992 | +151,056 | 0.17 | 0.19 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,232 | 133,359 | +123,127 | 0.00 | 0.06 | +0.06 | buy |
| UBS Group AG | 19,900 | 102,139 | +82,239 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 258,549 | 340,115 | +81,566 | 0.01 | 0.02 | +0.00 | buy |
| BRAIDWELL LP | 80,766 | 160,849 | +80,083 | 1.47 | 3.35 | +1.87 | buy |
| Assenagon Asset Management S.A. | 34,955 | 110,390 | +75,435 | 0.04 | 0.12 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 73,948 | +73,948 | 0.00 | 0.10 | +0.10 | buy |
| Qube Research & Technologies Ltd | 6,696 | 77,996 | +71,300 | 0.01 | 0.07 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 206,202 | 274,700 | +68,498 | 0.40 | 0.58 | +0.18 | buy |
| AMERIPRISE FINANCIAL INC | 7,013 | 68,876 | +61,863 | 0.00 | 0.01 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 29,611 | 80,000 | +50,389 | 0.61 | 2.27 | +1.66 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 89,787 | 138,637 | +48,850 | 0.10 | 0.15 | +0.06 | buy |
| FMR LLC | 5,618,222 | 5,663,207 | +44,985 | 0.21 | 0.21 | +0.01 | buy |
| CITADEL ADVISORS LLC | 514,105 | 551,939 | +37,834 | 0.29 | 0.32 | +0.03 | buy |
| Verition Fund Management LLC | 3,183 | 39,929 | +36,746 | 0.01 | 0.14 | +0.13 | buy |
| Clearbridge Investments, LLC | 629,828 | 664,368 | +34,540 | 0.31 | 0.34 | +0.03 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 27,900 | 62,074 | +34,174 | 0.04 | 0.08 | +0.04 | buy |
| Allspring Global Investments Holdings, LLC | 144,211 | 176,450 | +32,239 | 0.14 | 0.17 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 30,200 | +30,200 | 0.00 | 0.04 | +0.04 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 29,541 | +29,541 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 46,357 | 75,645 | +29,288 | 0.10 | 0.17 | +0.06 | buy |
| Soleus Capital Management, L.P. | 0 | 28,940 | +28,940 | 0.00 | 1.34 | +1.34 | buy |
| BNP Paribas Asset Management Holding S.A. | 375 | 25,370 | +24,995 | 0.00 | 0.04 | +0.04 | buy |
| Checkpoint Capital L.P. | 92,500 | 115,000 | +22,500 | 28.95 | 37.34 | +8.39 | buy |
| GOLDMAN SACHS GROUP INC | 146,960 | 168,765 | +21,805 | 0.02 | 0.02 | +0.00 | buy |
| CenterBook Partners LP | 2,155 | 20,323 | +18,168 | 0.08 | 0.77 | +0.69 | buy |
| AGF MANAGEMENT LTD | 0 | 18,159 | +18,159 | 0.00 | 0.06 | +0.06 | buy |
| Jump Financial, LLC | 0 | 18,000 | +18,000 | 0.00 | 0.17 | +0.17 | buy |
| ORBIMED ADVISORS LLC | 189,700 | 206,700 | +17,000 | 2.42 | 2.94 | +0.52 | buy |
| PineBridge Investments, L.P. | 56,925 | 73,175 | +16,250 | 0.26 | 0.34 | +0.08 | buy |
| Woodline Partners LP | 74,237 | 89,796 | +15,559 | 0.31 | 0.35 | +0.04 | buy |
| OLD MISSION CAPITAL LLC | 0 | 14,977 | +14,977 | 0.00 | 0.17 | +0.17 | buy |
| WELLS FARGO & COMPANY/MN | 52,711 | 67,263 | +14,552 | 0.01 | 0.01 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 13,800 | +13,800 | 0.00 | 0.17 | +0.17 | buy |
| Engineers Gate Manager LP | 3,563 | 17,339 | +13,776 | 0.04 | 0.17 | +0.13 | buy |
| Prosight Management, LP | 0 | 13,700 | +13,700 | 0.00 | 2.66 | +2.66 | buy |
| DIADEMA PARTNERS LP | 679 | 12,279 | +11,600 | 0.48 | 5.74 | +5.26 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 9,637 | +9,637 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 104,144 | 113,743 | +9,599 | 1.17 | 1.34 | +0.17 | buy |
| Headlands Technologies LLC | 0 | 8,074 | +8,074 | 0.00 | 0.54 | +0.54 | buy |
| Bank of New York Mellon Corp | 6,362 | 14,283 | +7,921 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 22,664 | 30,421 | +7,757 | 0.04 | 0.04 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 7,512 | +7,512 | 0.00 | 0.11 | +0.11 | buy |
| DIMENSIONAL FUND ADVISORS LP | 24,929 | 32,241 | +7,312 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,322 | 22,535 | +7,213 | 0.01 | 0.01 | +0.00 | buy |
| NAVELLIER & ASSOCIATES INC | 0 | 6,725 | +6,725 | 0.00 | 0.61 | +0.61 | buy |
| Trexquant Investment LP | 0 | 6,059 | +6,059 | 0.00 | 0.04 | +0.04 | buy |
| Ensign Peak Advisors, Inc | 40,164 | 45,952 | +5,788 | 0.04 | 0.05 | +0.01 | buy |
| NATIXIS ADVISORS, LLC | 15,923 | 21,236 | +5,313 | 0.02 | 0.02 | +0.00 | buy |
| PFM Health Sciences, LP | 63,699 | 68,999 | +5,300 | 2.98 | 3.13 | +0.15 | buy |
| OMERS ADMINISTRATION Corp | 0 | 4,900 | +4,900 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 555 | 5,404 | +4,849 | 0.01 | 0.10 | +0.09 | buy |
| LPL Financial LLC | 16,317 | 20,880 | +4,563 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 0 | 4,477 | +4,477 | 0.00 | 0.09 | +0.09 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 75,037 | 79,468 | +4,431 | 0.01 | 0.02 | +0.00 | buy |
| Handelsbanken Fonder AB | 33,647 | 38,050 | +4,403 | 0.08 | 0.09 | +0.01 | buy |
| Jain Global LLC | 0 | 4,090 | +4,090 | 0.00 | 0.05 | +0.05 | buy |
| Panoramic Capital, LLC | 0 | 4,000 | +4,000 | 0.00 | 2.96 | +2.96 | buy |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 4,309 | 8,124 | +3,815 | 0.07 | 0.08 | +0.01 | buy |
| Optiver Holding B.V. | 0 | 3,795 | +3,795 | 0.00 | 0.09 | +0.09 | buy |
| MML INVESTORS SERVICES, LLC | 8,844 | 12,506 | +3,662 | 0.02 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 2,040 | 5,543 | +3,503 | 0.11 | 0.17 | +0.06 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 4,653 | 7,635 | +2,982 | 0.01 | 0.01 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 2,924 | +2,924 | 0.00 | 0.28 | +0.28 | buy |
| Persistent Asset Partners Ltd | 0 | 2,766 | +2,766 | 0.00 | 1.44 | +1.44 | buy |
| Calamos Advisors LLC | 0 | 2,640 | +2,640 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 134,591 | 137,197 | +2,606 | 0.02 | 0.02 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 430 | 2,800 | +2,370 | 0.23 | 1.35 | +1.13 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 2,328 | +2,328 | 0.00 | 0.11 | +0.11 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 19,401 | 21,574 | +2,173 | 0.60 | 0.52 | -0.08 | buy |
| STATE STREET CORP | 1,934 | 4,094 | +2,160 | 0.00 | 0.00 | +0.00 | buy |
| Quantum Portfolio Management LLC | 0 | 2,148 | +2,148 | 0.00 | 0.64 | +0.64 | buy |
| Maryland State Retirement & Pension System | 3,510 | 5,623 | +2,113 | 0.05 | 0.08 | +0.03 | buy |
| SIH Partners, LLLP | 0 | 2,006 | +2,006 | 0.00 | 0.10 | +0.10 | buy |
| J. Goldman & Co LP | 0 | 2,000 | +2,000 | 0.00 | 0.04 | +0.04 | buy |
| ABC ARBITRAGE SA | 0 | 1,758 | +1,758 | 0.00 | 0.19 | +0.19 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 47,354 | 49,071 | +1,717 | 0.24 | 0.28 | +0.04 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 1,501 | +1,501 | 0.00 | 0.62 | +0.62 | buy |
| WEXFORD CAPITAL LP | 0 | 1,500 | +1,500 | 0.00 | 0.23 | +0.23 | buy |
| Federation des caisses Desjardins du Quebec | 1,421 | 2,921 | +1,500 | 0.00 | 0.01 | +0.00 | buy |
| FORA Capital, LLC | 0 | 1,473 | +1,473 | 0.00 | 0.09 | +0.09 | buy |
| Cerity Partners LLC | 3,202 | 4,654 | +1,452 | 0.00 | 0.01 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 0 | 1,442 | +1,442 | 0.00 | 0.04 | +0.04 | buy |
| NewEdge Advisors, LLC | 24 | 1,455 | +1,431 | 0.00 | 0.01 | +0.01 | buy |
| Cetera Investment Advisers | 4,127 | 5,491 | +1,364 | 0.01 | 0.01 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 0 | 1,347 | +1,347 | 0.00 | 0.00 | +0.00 | buy |
| R Squared Ltd | 0 | 1,340 | +1,340 | 0.00 | 0.85 | +0.85 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,120 | 2,395 | +1,275 | 0.05 | 0.05 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 666 | 1,873 | +1,207 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 1,198 | +1,198 | 0.00 | 0.02 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 914 | 2,079 | +1,165 | 0.00 | 0.00 | +0.00 | buy |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | 1,146 | +1,146 | 0.00 | 3.25 | +3.25 | buy |
| Legal & General Group Plc | 112,970 | 114,094 | +1,124 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 1,098 | +1,098 | 0.00 | 0.10 | +0.10 | buy |
| Quantinno Capital Management LP | 3,386 | 4,479 | +1,093 | 0.02 | 0.02 | -0.00 | buy |
| TimesSquare Capital Management, LLC | 124,245 | 125,295 | +1,050 | 1.11 | 1.19 | +0.08 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 985 | +985 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 900 | +900 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 9,433 | 10,287 | +854 | 0.01 | 0.01 | +0.00 | buy |