| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,592,319 | 4,991,034 | -601,285 | 0.24 | 0.19 | -0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,362,324 | 3,374,955 | +12,631 | 0.30 | 0.28 | -0.02 | buy |
| JANUS HENDERSON GROUP PLC | 2,458,164 | 2,541,732 | +83,568 | 0.92 | 0.88 | -0.04 | buy |
| Capital World Investors | 1,916,234 | 2,256,216 | +339,982 | 0.22 | 0.22 | +0.01 | buy |
| Artisan Partners Limited Partnership | 1,756,942 | 1,467,982 | -288,960 | 2.26 | 1.75 | -0.51 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 679,236 | 1,021,457 | +342,221 | 0.10 | 0.14 | +0.04 | buy |
| Avoro Capital Advisors LLC | 990,000 | 1,000,000 | +10,000 | 8.18 | 7.19 | -0.99 | buy |
| BlackRock, Inc. | 735,598 | 808,337 | +72,739 | 0.01 | 0.01 | -0.00 | buy |
| RTW INVESTMENTS, LP | 673,497 | 709,446 | +35,949 | 5.67 | 5.16 | -0.52 | buy |
| Invesco Ltd. | 416,408 | 594,697 | +178,289 | 0.04 | 0.06 | +0.01 | buy |
| MORGAN STANLEY | 518,852 | 560,711 | +41,859 | 0.03 | 0.02 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 414,182 | 422,304 | +8,122 | 0.11 | 0.11 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 400,776 | 400,117 | -659 | 0.02 | 0.02 | -0.00 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 356,870 | 340,285 | -16,585 | 0.91 | 0.97 | +0.06 | sell |
| Bellevue Group AG | 461,854 | 313,000 | -148,854 | 7.36 | 5.44 | -1.92 | sell |
| SEI INVESTMENTS CO | 330,506 | 286,966 | -43,540 | 0.27 | 0.19 | -0.08 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 223,666 | 266,067 | +42,401 | 0.52 | 0.64 | +0.12 | buy |
| JENNISON ASSOCIATES LLC | 229,761 | 237,468 | +7,707 | 0.12 | 0.12 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 237,701 | 233,493 | -4,208 | 0.05 | 0.04 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 167,206 | 231,985 | +64,779 | 0.02 | 0.02 | +0.00 | buy |
| Clearbridge Investments, LLC | 513,764 | 231,356 | -282,408 | 0.35 | 0.15 | -0.20 | sell |
| CITADEL ADVISORS LLC | 350,851 | 219,126 | -131,725 | 0.20 | 0.11 | -0.09 | sell |
| Fiera Capital Corp | 225,971 | 217,198 | -8,773 | 0.60 | 0.54 | -0.06 | sell |
| AMERIPRISE FINANCIAL INC | 187,139 | 215,910 | +28,771 | 0.04 | 0.04 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 70,744 | 177,836 | +107,092 | 0.04 | 0.09 | +0.05 | buy |
| Allspring Global Investments Holdings, LLC | 172,732 | 175,311 | +2,579 | 0.24 | 0.22 | -0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 221,048 | 173,700 | -47,348 | 0.09 | 0.07 | -0.03 | sell |
| Checkpoint Capital L.P. | 142,000 | 153,000 | +11,000 | 37.83 | 40.10 | +2.26 | buy |
| LORD, ABBETT & CO. LLC | 203,864 | 152,083 | -51,781 | 0.53 | 0.36 | -0.16 | sell |
| Legal & General Group Plc | 144,355 | 150,850 | +6,495 | 0.03 | 0.03 | -0.00 | buy |
| Pictet Asset Management Holding SA | 153,211 | 148,306 | -4,905 | 0.13 | 0.11 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 134,710 | 139,381 | +4,671 | 0.04 | 0.03 | -0.00 | buy |
| BAMCO INC /NY/ | 153,719 | 138,648 | -15,071 | 0.35 | 0.31 | -0.04 | sell |
| ORBIMED ADVISORS LLC | 146,000 | 136,900 | -9,100 | 2.51 | 2.18 | -0.33 | sell |
| LAZARD ASSET MANAGEMENT LLC | 133,030 | 133,347 | +317 | 0.19 | 0.16 | -0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 115,358 | 129,147 | +13,789 | 0.11 | 0.11 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 121,221 | 125,657 | +4,436 | 1.59 | 1.52 | -0.08 | buy |
| AGF MANAGEMENT LTD | 124,691 | 125,069 | +378 | 0.45 | 0.41 | -0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 258,556 | 109,121 | -149,435 | 0.32 | 0.07 | -0.26 | sell |
| FIRST TRUST ADVISORS LP | 53,902 | 107,195 | +53,293 | 0.03 | 0.06 | +0.02 | buy |
| Rock Springs Capital Management LP | 103,250 | 98,500 | -4,750 | 4.45 | 4.24 | -0.22 | sell |
| FEDERATED HERMES, INC. | 106,770 | 95,253 | -11,517 | 0.15 | 0.11 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 90,000 | +90,000 | 0.00 | 0.10 | +0.10 | buy |
| BANK OF MONTREAL /CAN/ | 16,377 | 85,333 | +68,956 | 0.01 | 0.03 | +0.02 | buy |
| BRAIDWELL LP | 31,007 | 84,939 | +53,932 | 0.83 | 2.07 | +1.24 | buy |
| 1832 Asset Management L.P. | 110,700 | 84,200 | -26,500 | 0.12 | 0.08 | -0.04 | sell |
| TimesSquare Capital Management, LLC | 108,509 | 83,117 | -25,392 | 1.37 | 1.03 | -0.34 | sell |
| Aberdeen Group plc | 52,347 | 82,106 | +29,759 | 0.07 | 0.10 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 101,523 | 80,824 | -20,699 | 0.07 | 0.05 | -0.02 | sell |
| Eagle Health Investments LP | 62,730 | 76,336 | +13,606 | 11.59 | 11.70 | +0.11 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 36,600 | 73,300 | +36,700 | 0.10 | 0.17 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 60,458 | 72,365 | +11,907 | 0.04 | 0.04 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 90,452 | 71,598 | -18,854 | 0.13 | 0.10 | -0.04 | sell |
| PGGM Investments | 54,830 | 71,514 | +16,684 | 0.73 | 0.92 | +0.19 | buy |
| Nuveen, LLC | 66,241 | 66,241 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BESSEMER GROUP INC | 62,537 | 64,251 | +1,714 | 0.08 | 0.07 | -0.01 | buy |
| Amundi | 42,485 | 61,433 | +18,948 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 79,989 | 61,418 | -18,571 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 64,244 | 58,706 | -5,538 | 0.01 | 0.01 | -0.00 | sell |
| Handelsbanken Fonder AB | 52,678 | 54,926 | +2,248 | 0.13 | 0.13 | -0.00 | buy |
| Candriam S.C.A. | 48,741 | 54,148 | +5,407 | 0.20 | 0.21 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 45,533 | 52,122 | +6,589 | 0.03 | 0.03 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,408 | 49,330 | -8,078 | 0.04 | 0.03 | -0.01 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 49,358 | 49,306 | -52 | 0.11 | 0.09 | -0.01 | sell |
| VAN ECK ASSOCIATES CORP | 34,535 | 40,397 | +5,862 | 0.02 | 0.02 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 44,027 | 39,437 | -4,590 | 0.05 | 0.04 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 36,817 | 38,794 | +1,977 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 28,485 | 38,438 | +9,953 | 0.03 | 0.03 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,390 | 38,104 | -16,286 | 0.01 | 0.01 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 57,489 | 36,802 | -20,687 | 0.02 | 0.01 | -0.01 | sell |
| Patient Square Capital LP | 26,000 | 36,718 | +10,718 | 4.68 | 4.76 | +0.08 | buy |
| ROYAL BANK OF CANADA | 35,660 | 32,917 | -2,743 | 0.01 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 33,847 | 32,255 | -1,592 | 0.02 | 0.02 | -0.00 | sell |
| UBS Group AG | 60,384 | 31,647 | -28,737 | 0.01 | 0.00 | -0.01 | sell |
| Tri Locum Partners LP | 37,653 | 31,635 | -6,018 | 4.11 | 3.24 | -0.87 | sell |
| Jefferies Financial Group Inc. | 30,000 | 30,005 | +5 | 0.21 | 0.27 | +0.06 | buy |
| Hudson Bay Capital Management LP | 21,822 | 30,000 | +8,178 | 0.11 | 0.13 | +0.03 | buy |
| Artia Global Partners LP | 64,699 | 29,739 | -34,960 | 8.74 | 4.90 | -3.84 | sell |
| Perpetual Ltd | 30,950 | 28,359 | -2,591 | 0.38 | 0.32 | -0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,505 | 27,506 | +6,001 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 22,451 | 25,536 | +3,085 | 0.03 | 0.03 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 25,174 | 25,174 | 0 | 0.12 | 0.11 | -0.02 | hold |
| ODDO BHF ASSET MANAGEMENT SAS | 23,473 | 25,009 | +1,536 | 0.74 | 0.72 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 23,695 | 23,569 | -126 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 3,806 | 23,488 | +19,682 | 0.03 | 0.16 | +0.13 | buy |
| LPL Financial LLC | 25,656 | 23,247 | -2,409 | 0.01 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 14,112 | 22,651 | +8,539 | 0.04 | 0.07 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 26,340 | 22,407 | -3,933 | 0.06 | 0.05 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 11,552 | 21,023 | +9,471 | 0.01 | 0.01 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 22,500 | 20,380 | -2,120 | 0.03 | 0.02 | -0.01 | sell |
| HSBC HOLDINGS PLC | 0 | 20,379 | +20,379 | 0.00 | 0.01 | +0.01 | buy |
| MIROVA | 0 | 19,833 | +19,833 | 0.00 | 0.59 | +0.59 | buy |
| HRT FINANCIAL LP | 19,684 | 18,754 | -930 | 0.05 | 0.03 | -0.02 | sell |
| Squarepoint Ops LLC | 28,202 | 18,679 | -9,523 | 0.05 | 0.03 | -0.02 | sell |
| Bank of New York Mellon Corp | 16,549 | 17,183 | +634 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 554 | 16,802 | +16,248 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 24,347 | 14,786 | -9,561 | 0.03 | 0.02 | -0.01 | sell |
| DCF Advisers, LLC | 13,650 | 14,650 | +1,000 | 3.79 | 4.03 | +0.24 | buy |
| Allianz Asset Management GmbH | 3,001 | 14,401 | +11,400 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,959 | 14,392 | -9,567 | 0.03 | 0.01 | -0.01 | sell |