| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,991,034 | 5,231,452 | +240,418 | 0.19 | 0.21 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,374,955 | 2,678,047 | -696,908 | 0.28 | 0.25 | -0.04 | sell |
| Capital World Investors | 2,256,216 | 2,199,770 | -56,446 | 0.22 | 0.24 | +0.02 | sell |
| Artisan Partners Limited Partnership | 1,467,982 | 1,508,778 | +40,796 | 1.75 | 2.28 | +0.53 | buy |
| Avoro Capital Advisors LLC | 1,000,000 | 1,000,000 | 0 | 7.19 | 8.33 | +1.14 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,021,457 | 930,548 | -90,909 | 0.14 | 0.15 | +0.01 | sell |
| BlackRock, Inc. | 808,337 | 777,237 | -31,100 | 0.01 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 709,446 | 709,446 | 0 | 5.16 | 5.62 | +0.46 | hold |
| MORGAN STANLEY | 560,711 | 643,123 | +82,412 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 594,697 | 443,990 | -150,707 | 0.06 | 0.03 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 400,117 | 400,234 | +117 | 0.02 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 422,304 | 395,661 | -26,643 | 0.11 | 0.10 | -0.02 | sell |
| Bellevue Group AG | 313,000 | 301,000 | -12,000 | 5.44 | 5.88 | +0.44 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 340,285 | 298,599 | -41,686 | 0.97 | 1.03 | +0.05 | sell |
| BESSEMER GROUP INC | 64,251 | 267,779 | +203,528 | 0.07 | 0.34 | +0.27 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 266,067 | 264,617 | -1,450 | 0.64 | 0.74 | +0.10 | sell |
| SEI INVESTMENTS CO | 286,966 | 255,073 | -31,893 | 0.19 | 0.21 | +0.02 | sell |
| Clearbridge Investments, LLC | 231,356 | 253,776 | +22,420 | 0.15 | 0.19 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 237,468 | 226,200 | -11,268 | 0.12 | 0.13 | +0.01 | sell |
| FRANKLIN RESOURCES INC | 233,493 | 224,930 | -8,563 | 0.04 | 0.05 | +0.00 | sell |
| CITADEL ADVISORS LLC | 219,126 | 212,416 | -6,710 | 0.11 | 0.11 | -0.00 | sell |
| Pictet Asset Management Holding SA | 148,306 | 198,282 | +49,976 | 0.11 | 0.18 | +0.06 | buy |
| TWO SIGMA INVESTMENTS, LP | 109,121 | 185,638 | +76,517 | 0.07 | 0.13 | +0.06 | buy |
| AMERIPRISE FINANCIAL INC | 215,910 | 181,464 | -34,446 | 0.04 | 0.03 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 231,985 | 177,846 | -54,139 | 0.02 | 0.02 | -0.00 | sell |
| Legal & General Group Plc | 150,850 | 177,164 | +26,314 | 0.03 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 173,700 | 173,193 | -507 | 0.07 | 0.07 | +0.01 | sell |
| Allspring Global Investments Holdings, LLC | 175,311 | 170,829 | -4,482 | 0.22 | 0.24 | +0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 177,836 | 157,958 | -19,878 | 0.09 | 0.08 | -0.01 | sell |
| 1832 Asset Management L.P. | 84,200 | 157,940 | +73,740 | 0.08 | 0.18 | +0.10 | buy |
| DEUTSCHE BANK AG\ | 139,381 | 137,335 | -2,046 | 0.03 | 0.04 | +0.00 | sell |
| BAMCO INC /NY/ | 138,648 | 136,654 | -1,994 | 0.31 | 0.19 | -0.12 | sell |
| BARCLAYS PLC | 5,500 | 134,427 | +128,927 | 0.00 | 0.04 | +0.04 | buy |
| LAZARD ASSET MANAGEMENT LLC | 133,347 | 131,996 | -1,351 | 0.16 | 0.19 | +0.03 | sell |
| Checkpoint Capital L.P. | 153,000 | 131,283 | -21,717 | 40.10 | 31.25 | -8.85 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 125,657 | 125,668 | +11 | 1.52 | 1.56 | +0.04 | buy |
| AGF MANAGEMENT LTD | 125,069 | 125,481 | +412 | 0.41 | 0.45 | +0.04 | buy |
| BNP Paribas Asset Management Holding S.A. | 129,147 | 121,786 | -7,361 | 0.11 | 0.11 | +0.00 | sell |
| LORD, ABBETT & CO. LLC | 152,083 | 108,253 | -43,830 | 0.36 | 0.29 | -0.08 | sell |
| FIRST TRUST ADVISORS LP | 107,195 | 101,440 | -5,755 | 0.06 | 0.06 | -0.00 | sell |
| PGGM Investments | 71,514 | 96,511 | +24,997 | 0.92 | 2.20 | +1.29 | buy |
| MILLENNIUM MANAGEMENT LLC | 72,365 | 94,401 | +22,036 | 0.04 | 0.06 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 136,900 | 92,880 | -44,020 | 2.18 | 1.63 | -0.55 | sell |
| Fiera Capital Corp | 217,198 | 90,423 | -126,775 | 0.54 | 0.30 | -0.24 | sell |
| Capital Research Global Investors | 0 | 88,511 | +88,511 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 95,253 | 87,288 | -7,965 | 0.11 | 0.12 | +0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 73,300 | 84,300 | +11,000 | 0.17 | 0.21 | +0.04 | buy |
| Aberdeen Group plc | 82,106 | 83,822 | +1,716 | 0.10 | 0.11 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 83,117 | 83,114 | -3 | 1.03 | 1.13 | +0.10 | sell |
| Candriam S.C.A. | 54,148 | 80,120 | +25,972 | 0.21 | 0.33 | +0.13 | buy |
| BANK OF MONTREAL /CAN/ | 85,333 | 77,213 | -8,120 | 0.03 | 0.03 | +0.00 | sell |
| Eagle Health Investments LP | 76,336 | 76,417 | +81 | 11.70 | 11.75 | +0.05 | buy |
| Nuveen, LLC | 66,241 | 74,128 | +7,887 | 0.01 | 0.02 | +0.00 | buy |
| Amundi | 61,433 | 65,122 | +3,689 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 58,706 | 62,219 | +3,513 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 27,506 | 61,312 | +33,806 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 60,577 | +60,577 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 18,679 | 58,400 | +39,721 | 0.03 | 0.11 | +0.08 | buy |
| USS Investment Management Ltd | 12,144 | 57,903 | +45,759 | 0.03 | 0.19 | +0.16 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 57,082 | +57,082 | 0.00 | 0.17 | +0.17 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 61,418 | 55,346 | -6,072 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 0 | 55,025 | +55,025 | 0.00 | 0.16 | +0.16 | buy |
| Rock Springs Capital Management LP | 98,500 | 52,750 | -45,750 | 4.24 | 2.39 | -1.85 | sell |
| Handelsbanken Fonder AB | 54,926 | 52,653 | -2,273 | 0.13 | 0.14 | +0.01 | sell |
| Ensign Peak Advisors, Inc | 71,598 | 52,027 | -19,571 | 0.10 | 0.08 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 90,000 | 50,607 | -39,393 | 0.10 | 0.07 | -0.04 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 49,306 | 49,179 | -127 | 0.09 | 0.10 | +0.00 | sell |
| Jefferies Financial Group Inc. | 30,005 | 45,068 | +15,063 | 0.27 | 0.38 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 38,794 | 44,408 | +5,614 | 0.01 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 31,635 | 41,596 | +9,961 | 3.24 | 4.75 | +1.50 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 40,062 | +40,062 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 39,983 | +39,983 | 0.00 | 0.06 | +0.06 | buy |
| UBS Group AG | 31,647 | 36,583 | +4,936 | 0.00 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 36,802 | 34,757 | -2,045 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 38,104 | 34,453 | -3,651 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 32,255 | 30,865 | -1,390 | 0.02 | 0.02 | +0.00 | sell |
| Mediolanum International Funds Ltd | 0 | 29,785 | +29,785 | 0.00 | 0.23 | +0.23 | buy |
| Artia Global Partners LP | 29,739 | 29,739 | 0 | 4.90 | 5.25 | +0.35 | hold |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 29,732 | +29,732 | 0.00 | 0.90 | +0.90 | buy |
| ROYAL BANK OF CANADA | 32,917 | 28,562 | -4,355 | 0.00 | 0.00 | -0.00 | sell |
| Perpetual Ltd | 28,359 | 28,246 | -113 | 0.32 | 0.37 | +0.06 | sell |
| BLAIR WILLIAM & CO/IL | 22,407 | 27,666 | +5,259 | 0.05 | 0.07 | +0.02 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 25,009 | 25,009 | 0 | 0.72 | 1.07 | +0.35 | hold |
| TD ASSET MANAGEMENT INC | 80,824 | 24,675 | -56,149 | 0.05 | 0.02 | -0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 23,569 | 23,861 | +292 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 36,718 | 23,000 | -13,718 | 4.76 | 3.31 | -1.45 | sell |
| VAN ECK ASSOCIATES CORP | 40,397 | 22,193 | -18,204 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,437 | 22,082 | -17,355 | 0.04 | 0.03 | -0.01 | sell |
| Soleus Capital Management, L.P. | 3,500 | 19,955 | +16,455 | 0.10 | 0.64 | +0.53 | buy |
| LPL Financial LLC | 23,247 | 19,499 | -3,748 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS ADVISORS, LLC | 20,380 | 19,088 | -1,292 | 0.02 | 0.02 | -0.00 | sell |
| Jain Global LLC | 4,641 | 18,913 | +14,272 | 0.04 | 0.21 | +0.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 22,651 | 18,797 | -3,854 | 0.07 | 0.07 | +0.01 | sell |
| BRAIDWELL LP | 84,939 | 17,707 | -67,232 | 2.07 | 0.61 | -1.46 | sell |
| HRT FINANCIAL LP | 18,754 | 17,498 | -1,256 | 0.03 | 0.03 | -0.00 | sell |
| Bank of New York Mellon Corp | 17,183 | 16,971 | -212 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 14,786 | 16,531 | +1,745 | 0.02 | 0.02 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,330 | 16,407 | -32,923 | 0.03 | 0.01 | -0.02 | sell |
| FIL Ltd | 0 | 16,249 | +16,249 | 0.00 | 0.01 | +0.01 | buy |
| MIROVA | 19,833 | 15,891 | -3,942 | 0.59 | 0.54 | -0.04 | sell |