| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 132,435 | 581,586 | +449,151 | 0.02 | 0.10 | +0.08 | buy |
| JENNISON ASSOCIATES LLC | 1,143,378 | 1,511,745 | +368,367 | 0.37 | 0.63 | +0.27 | buy |
| JANUS HENDERSON GROUP PLC | 1,783,453 | 1,471,138 | +312,315 | 0.44 | 0.48 | 0.00 | sell |
| Capital World Investors | 1,182,449 | 1,431,021 | +248,572 | 0.09 | 0.14 | +0.05 | buy |
| Clearbridge Investments, LLC | 169,470 | 344,364 | +174,894 | 0.06 | 0.16 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 179,364 | 316,380 | +137,016 | 0.24 | 0.58 | +0.34 | buy |
| Paradigm Biocapital Advisors LP | 142,259 | 261,443 | +119,184 | 4.49 | 8.77 | +4.28 | buy |
| PERCEPTIVE ADVISORS LLC | 69,000 | 150,600 | +81,600 | 0.78 | 2.49 | +1.71 | buy |
| CITADEL ADVISORS LLC | 360,588 | 436,123 | +75,535 | 0.22 | 0.32 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 205,893 | 278,322 | +72,429 | 0.11 | 0.18 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 159,518 | 92,237 | +67,281 | 0.18 | 0.13 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 123,580 | 175,371 | +51,791 | 0.06 | 0.10 | +0.05 | buy |
| Sofinnova Investments, Inc. | 39,921 | 78,186 | +38,265 | 1.03 | 2.67 | +1.64 | buy |
| BAMCO INC /NY/ | 250,268 | 287,991 | +37,723 | 0.27 | 0.41 | +0.14 | buy |
| Qube Research & Technologies Ltd | 35,774 | 72,944 | +37,170 | 0.06 | 0.11 | 0.00 | buy |
| Hudson Bay Capital Management LP | 36,936 | 68,003 | +31,067 | 0.14 | 0.32 | +0.17 | buy |
| D. E. Shaw & Co., Inc. | 180,253 | 211,286 | +31,033 | 0.13 | 0.20 | 0.00 | buy |
| Integral Health Asset Management, LLC | 40,000 | 70,000 | +30,000 | 2.05 | 4.88 | +2.84 | buy |
| RTW INVESTMENTS, LP | 482,195 | 507,195 | +25,000 | 3.58 | 5.26 | +1.68 | buy |
| Allspring Global Investments Holdings, LLC | 90,965 | 70,756 | +20,209 | 0.06 | 0.06 | 0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 61,512 | 81,112 | +19,600 | 0.05 | 0.10 | 0.00 | buy |
| Holocene Advisors, LP | 358,256 | 372,155 | +13,899 | 0.61 | 0.82 | +0.21 | buy |
| TimesSquare Capital Management, LLC | 90,690 | 101,750 | +11,060 | 0.51 | 0.78 | +0.27 | buy |
| Polar Asset Management Partners Inc. | 6,200 | 17,100 | +10,900 | 0.05 | 0.20 | +0.15 | buy |
| Zimmer Partners, LP | 4,800 | 15,200 | +10,400 | 0.05 | 0.20 | +0.15 | buy |
| Fairmount Funds Management LLC | 73,526 | 83,747 | +10,221 | 4.04 | 4.95 | +0.91 | buy |
| ExodusPoint Capital Management, LP | 24,012 | 14,281 | +9,731 | 0.11 | 0.09 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 114,000 | 104,700 | +9,300 | 0.07 | 0.10 | +0.03 | sell |
| CANADA LIFE ASSURANCE Co | 7,531 | 15,598 | +8,067 | 0.01 | 0.02 | +0.01 | buy |
| Erste Asset Management GmbH | 8,800 | 16,800 | +8,000 | 0.06 | 0.14 | +0.08 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 10,000 | 16,000 | +6,000 | 0.09 | 0.21 | +0.12 | buy |
| Saturn V Capital Management LP | 4,081 | 10,074 | +5,993 | 0.88 | 2.07 | +1.19 | buy |
| Fiera Capital Corp | 158,243 | 161,974 | +3,731 | 0.18 | 0.25 | +0.08 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 17,390 | 14,381 | +3,009 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 61,390 | 64,382 | +2,992 | 0.01 | 0.01 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 4,569 | 7,531 | +2,962 | 0.02 | 0.05 | 0.00 | buy |
| Artia Global Partners LP | 46,438 | 49,238 | +2,800 | 6.24 | 10.06 | +3.82 | buy |
| SUMMIT SECURITIES GROUP LLC | 100 | 2,006 | +1,906 | 0.02 | 0.69 | +0.68 | buy |
| TOWNSQUARE CAPITAL LLC | 1,751 | 3,442 | +1,691 | 0.01 | 0.03 | 0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 5,352 | 6,924 | +1,572 | 0.01 | 0.02 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 6,848 | 8,132 | +1,284 | 0.01 | 0.02 | +0.01 | buy |
| Gilbert & Cook, Inc. | 608 | 1,844 | +1,236 | 0.04 | 0.14 | +0.10 | buy |
| Quantinno Capital Management LP | 886 | 1,689 | +803 | 0.02 | 0.04 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 4,991 | 4,220 | +771 | 0.02 | 0.02 | 0.00 | sell |
| J. Goldman & Co LP | 675 | 1,350 | +675 | 0.02 | 0.03 | +0.02 | buy |
| USS Investment Management Ltd | 11,675 | 12,171 | +496 | 0.05 | 0.06 | +0.01 | buy |
| Atria Investments, Inc | 2,653 | 3,134 | +481 | 0.02 | 0.03 | +0.01 | buy |
| Eversept Partners, LP | 4,154 | 4,565 | +411 | 0.17 | 0.25 | +0.08 | buy |
| China Universal Asset Management Co., Ltd. | 391 | 761 | +370 | 0.05 | 0.11 | +0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 1,600 | 1,950 | +350 | 0.05 | 0.09 | +0.04 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 2,325 | 2,656 | +331 | 0.01 | 0.02 | 0.00 | buy |
| Values First Advisors, Inc. | 2,732 | 3,059 | +327 | 0.64 | 0.97 | +0.33 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,054 | 1,227 | +173 | 0.07 | 0.12 | +0.05 | buy |
| CI INVESTMENTS INC. | 1,085 | 926 | +159 | 0.00 | 0.00 | 0.00 | sell |
| Laird Norton Wetherby Wealth Management, LLC | 1,273 | 1,426 | +153 | 0.03 | 0.04 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 1,244 | 1,385 | +141 | 0.02 | 0.02 | 0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 521 | 588 | +67 | 0.01 | 0.01 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 1,789 | 1,730 | +59 | 0.00 | 0.00 | +0.00 | sell |
| Sequoia Financial Advisors, LLC | 1,706 | 1,752 | +46 | 0.01 | 0.02 | +0.00 | buy |
| Genus Capital Management Inc. | 1,580 | 1,605 | +25 | 0.09 | 0.12 | +0.03 | buy |
| NKCFO LLC | 95 | 116 | +21 | 0.02 | 0.03 | +0.01 | buy |
| ANTIPODES PARTNERS Ltd | 59 | 79 | +20 | 0.00 | 0.00 | +0.00 | buy |
| FULTON BANK, N.A. | 523 | 539 | +16 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 1,932 | 1,946 | +14 | 0.00 | 0.00 | 0.00 | buy |
| Prestige Wealth Management Group LLC | 6 | 4 | +2 | 0.00 | 0.00 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 36,330 | 36,323 | -7 | 0.18 | 0.23 | +0.05 | sell |
| JGP Global Gestao de Recursos Ltda. | 1,285 | 1,275 | -10 | 0.36 | 0.40 | +0.04 | sell |
| LOOMIS SAYLES & CO L P | 102 | 86 | -16 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 3,073 | 3,038 | -35 | 0.22 | 0.25 | +0.03 | sell |
| PROFUND ADVISORS LLC | 961 | 907 | -54 | 0.02 | 0.02 | +0.00 | sell |
| EFG Asset Management (Americas) Corp. | 960 | 861 | -99 | 0.09 | 0.10 | +0.01 | sell |
| OneAscent Wealth Management LLC | 541 | 440 | -101 | 0.10 | 0.09 | -0.00 | sell |
| Main Street Financial Solutions, LLC | 793 | 685 | -108 | 0.04 | 0.05 | +0.01 | sell |
| Moran Wealth Management, LLC | 6,438 | 6,312 | -126 | 0.09 | 0.12 | +0.03 | sell |
| PineBridge Investments, L.P. | 21,218 | 20,959 | -259 | 0.09 | 0.11 | +0.03 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 13,061 | 12,722 | -339 | 0.11 | 0.15 | +0.04 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 1,343 | 993 | -350 | 0.08 | 0.09 | +0.01 | sell |
| Evolutionary Tree Capital Management, LLC | 3,821 | 3,393 | -428 | 1.79 | 2.15 | +0.36 | sell |
| Beverly Hills Private Wealth, LLC | 866 | 410 | -456 | 0.07 | 0.06 | -0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,390 | 2,800 | -590 | 0.07 | 0.07 | +0.00 | sell |
| HighVista Strategies LLC | 1,778 | 1,067 | -711 | 0.32 | 0.24 | -0.07 | sell |
| GILDER GAGNON HOWE & CO LLC | 10,602 | 9,628 | -974 | 0.06 | 0.07 | +0.02 | sell |
| EFG Asset Management (North America) Corp. | 11,504 | 10,115 | -1,389 | 0.96 | 1.18 | +0.22 | sell |
| Nicholas Investment Partners, LP | 95,414 | 93,566 | -1,848 | 2.54 | 3.44 | +0.89 | sell |
| HHLR ADVISORS, LTD. | 18,665 | 16,765 | -1,900 | 0.15 | 0.18 | +0.03 | sell |
| Monashee Investment Management LLC | 10,000 | 7,500 | -2,500 | 0.93 | 1.54 | +0.61 | sell |
| Dorsey Wright & Associates | 4,258 | 1,418 | -2,840 | 0.50 | 0.22 | -0.28 | sell |
| OAK RIDGE INVESTMENTS LLC | 9,322 | 5,694 | -3,628 | 0.45 | 0.36 | -0.09 | sell |
| DCF Advisers, LLC | 25,700 | 22,000 | -3,700 | 6.91 | 7.55 | +0.63 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 134,830 | 127,136 | -7,694 | 0.07 | 0.09 | +0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 329,076 | 321,355 | -7,721 | 2.17 | 2.84 | +0.67 | sell |
| Bellevue Group AG | 923,284 | 911,530 | -11,754 | 5.13 | 7.22 | +2.09 | sell |
| Aquilo Capital Management, LLC | 16,315 | 3,715 | -12,600 | 4.17 | 1.66 | -2.52 | sell |
| AWM Investment Company, Inc. | 45,000 | 30,000 | -15,000 | 2.38 | 2.18 | -0.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 152,796 | 105,951 | -46,845 | 0.13 | 0.12 | -0.01 | sell |
| Rock Springs Capital Management LP | 350,000 | 259,000 | -91,000 | 3.25 | 3.41 | +0.17 | sell |
| T. Rowe Price Investment Management, Inc. | 1,064,839 | 966,356 | -98,483 | 0.28 | 0.34 | +0.05 | sell |
| Avidity Partners Management LP | 184,300 | 80,600 | -103,700 | 2.51 | 1.60 | -0.91 | sell |
| BAKER BROS. ADVISORS LP | 280,159 | 151,215 | -128,944 | 0.63 | 0.43 | -0.20 | sell |
| Artisan Partners Limited Partnership | 3,038,383 | 2,828,299 | -210,084 | 1.91 | 2.36 | +0.46 | sell |