| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,423,508 | 5,692,346 | +268,838 | 0.17 | 0.22 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,979,976 | 3,640,409 | -1,339,567 | 0.31 | 0.29 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 2,565,399 | 2,575,251 | +9,852 | 0.69 | 0.87 | +0.17 | buy |
| Artisan Partners Limited Partnership | 2,349,776 | 2,186,510 | -163,266 | 1.93 | 2.32 | +0.39 | sell |
| Capital World Investors | 1,951,082 | 1,959,504 | +8,422 | 0.16 | 0.20 | +0.04 | buy |
| Avoro Capital Advisors LLC | 1,175,000 | 990,000 | -185,000 | 11.34 | 9.45 | -1.90 | sell |
| Clearbridge Investments, LLC | 772,866 | 756,862 | -16,004 | 0.35 | 0.42 | +0.07 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 405,333 | 729,986 | +324,653 | 0.04 | 0.09 | +0.05 | buy |
| CITADEL ADVISORS LLC | 865,970 | 713,559 | -152,411 | 0.41 | 0.42 | +0.01 | sell |
| RTW INVESTMENTS, LP | 673,497 | 673,497 | 0 | 5.29 | 6.12 | +0.83 | hold |
| Bellevue Group AG | 571,039 | 546,328 | -24,711 | 6.94 | 8.37 | +1.43 | sell |
| BlackRock, Inc. | 550,146 | 523,801 | -26,345 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 429,291 | 435,106 | +5,815 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 429,844 | 347,518 | -82,326 | 0.21 | 0.20 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 336,120 | 342,379 | +6,259 | 0.01 | 0.02 | +0.00 | buy |
| SEI INVESTMENTS CO | 316,399 | 312,268 | -4,131 | 0.20 | 0.25 | +0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 43,882 | 294,160 | +250,278 | 0.04 | 0.33 | +0.29 | buy |
| FRANKLIN RESOURCES INC | 279,803 | 258,274 | -21,529 | 0.04 | 0.05 | +0.01 | sell |
| JENNISON ASSOCIATES LLC | 264,647 | 240,228 | -24,419 | 0.09 | 0.10 | +0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 205,906 | 229,770 | +23,864 | 0.06 | 0.09 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 184,987 | 211,330 | +26,343 | 0.17 | 0.26 | +0.09 | buy |
| LORD, ABBETT & CO. LLC | 101,079 | 196,877 | +95,798 | 0.18 | 0.43 | +0.25 | buy |
| GOLDMAN SACHS GROUP INC | 142,150 | 193,113 | +50,963 | 0.01 | 0.02 | +0.01 | buy |
| Fiera Capital Corp | 158,474 | 177,654 | +19,180 | 0.30 | 0.42 | +0.13 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 75,000 | 175,000 | +100,000 | 0.20 | 0.58 | +0.38 | buy |
| ORBIMED ADVISORS LLC | 208,000 | 172,300 | -35,700 | 2.88 | 3.05 | +0.16 | sell |
| Woodline Partners LP | 40,271 | 169,476 | +129,205 | 0.12 | 0.59 | +0.47 | buy |
| Pictet Asset Management Holding SA | 197,286 | 169,333 | -27,953 | 0.11 | 0.12 | +0.01 | sell |
| D. E. Shaw & Co., Inc. | 137,964 | 169,028 | +31,064 | 0.08 | 0.10 | +0.02 | buy |
| BAMCO INC /NY/ | 180,733 | 167,694 | -13,039 | 0.27 | 0.33 | +0.06 | sell |
| AMERIPRISE FINANCIAL INC | 111,195 | 165,658 | +54,463 | 0.02 | 0.03 | +0.01 | buy |
| Jefferies Financial Group Inc. | 155,400 | 155,000 | -400 | 1.41 | 1.05 | -0.37 | sell |
| Checkpoint Capital L.P. | 149,977 | 150,000 | +23 | 38.52 | 37.07 | -1.46 | buy |
| Legal & General Group Plc | 125,809 | 148,619 | +22,810 | 0.02 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 175,750 | 142,750 | -33,000 | 6.04 | 6.15 | +0.12 | sell |
| TWO SIGMA ADVISERS, LP | 14,000 | 139,700 | +125,700 | 0.02 | 0.21 | +0.19 | buy |
| LAZARD ASSET MANAGEMENT LLC | 127,488 | 137,196 | +9,708 | 0.10 | 0.14 | +0.04 | buy |
| TimesSquare Capital Management, LLC | 133,580 | 127,530 | -6,050 | 1.06 | 1.35 | +0.28 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 125,383 | 125,371 | -12 | 1.21 | 1.52 | +0.31 | sell |
| FEDERATED HERMES, INC. | 123,659 | 124,224 | +565 | 0.13 | 0.16 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 120,042 | 120,902 | +860 | 0.06 | 0.07 | +0.02 | buy |
| 1832 Asset Management L.P. | 172,400 | 110,700 | -61,700 | 0.17 | 0.14 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 66,795 | 106,714 | +39,919 | 0.03 | 0.06 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 93,336 | 96,361 | +3,025 | 0.09 | 0.12 | +0.03 | buy |
| PineBridge Investments, L.P. | 76,741 | 95,723 | +18,982 | 0.34 | 0.52 | +0.19 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 86,861 | 95,711 | +8,850 | 0.01 | 0.02 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 17,123 | 92,454 | +75,331 | 0.37 | 2.22 | +1.85 | buy |
| DEUTSCHE BANK AG\ | 19,930 | 88,724 | +68,794 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 243,746 | 84,919 | -158,827 | 0.02 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 53,835 | 84,753 | +30,918 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 0 | 81,400 | +81,400 | 0.00 | 0.02 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 87,414 | 80,632 | -6,782 | 0.12 | 0.15 | +0.04 | sell |
| Artia Global Partners LP | 78,311 | 78,311 | 0 | 11.10 | 10.16 | -0.94 | hold |
| Eagle Health Investments LP | 77,430 | 77,430 | 0 | 10.53 | 14.99 | +4.46 | hold |
| PGGM Investments | 76,699 | 76,699 | 0 | 0.73 | 0.92 | +0.18 | hold |
| BRAIDWELL LP | 194,491 | 76,091 | -118,400 | 3.67 | 1.67 | -2.00 | sell |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 90,895 | 73,595 | -17,300 | 0.11 | 0.10 | -0.01 | sell |
| NORTHERN TRUST CORP | 62,932 | 69,751 | +6,819 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 42,876 | 69,426 | +26,550 | 1.63 | 2.74 | +1.10 | buy |
| RAYMOND JAMES FINANCIAL INC | 72,588 | 68,794 | -3,794 | 0.01 | 0.02 | +0.00 | sell |
| Aberdeen Group plc | 70,293 | 66,676 | -3,617 | 0.07 | 0.08 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,243 | 65,286 | +2,043 | 0.03 | 0.04 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 64,102 | 65,122 | +1,020 | 0.05 | 0.06 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 58,770 | 64,985 | +6,215 | 0.03 | 0.04 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 62,804 | +62,804 | 0.00 | 0.08 | +0.08 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 39,300 | 58,491 | +19,191 | 0.08 | 0.14 | +0.06 | buy |
| ARMISTICE CAPITAL, LLC | 80,000 | 58,000 | -22,000 | 1.67 | 1.34 | -0.33 | sell |
| WELLS FARGO & COMPANY/MN | 55,381 | 55,674 | +293 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 68,276 | 53,793 | -14,483 | 0.01 | 0.01 | -0.00 | sell |
| Quadrature Capital Ltd | 20,501 | 50,603 | +30,102 | 0.19 | 0.44 | +0.25 | buy |
| JANE STREET GROUP, LLC | 16,520 | 49,904 | +33,384 | 0.01 | 0.04 | +0.03 | buy |
| Perpetual Ltd | 96,955 | 49,379 | -47,576 | 0.63 | 0.45 | -0.18 | sell |
| Candriam S.C.A. | 45,567 | 48,200 | +2,633 | 0.14 | 0.19 | +0.04 | buy |
| ROYAL BANK OF CANADA | 41,314 | 47,064 | +5,750 | 0.00 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 47,793 | 43,411 | -4,382 | 7.99 | 7.36 | -0.64 | sell |
| Handelsbanken Fonder AB | 39,753 | 41,105 | +1,352 | 0.08 | 0.10 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 35,993 | 40,220 | +4,227 | 0.00 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 43,953 | 38,767 | -5,186 | 4.52 | 4.29 | -0.23 | sell |
| BAKER BROS. ADVISORS LP | 37,760 | 37,760 | 0 | 0.20 | 0.20 | -0.00 | hold |
| VAN ECK ASSOCIATES CORP | 41,598 | 36,071 | -5,527 | 0.03 | 0.02 | -0.00 | sell |
| Qube Research & Technologies Ltd | 58,285 | 35,183 | -23,102 | 0.04 | 0.04 | -0.01 | sell |
| ODDO BHF ASSET MANAGEMENT SAS | 21,574 | 28,889 | +7,315 | 0.45 | 0.81 | +0.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 26,257 | 26,114 | -143 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 22,054 | 25,770 | +3,716 | 0.00 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 22,580 | 25,749 | +3,169 | 0.01 | 0.01 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 19,070 | 24,503 | +5,433 | 0.02 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,855 | 21,610 | +5,755 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 20,744 | 19,034 | -1,710 | 0.09 | 0.10 | +0.01 | sell |
| Squarepoint Ops LLC | 31,296 | 18,985 | -12,311 | 0.04 | 0.03 | -0.01 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 0 | 16,625 | +16,625 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 23,628 | 16,460 | -7,168 | 0.01 | 0.01 | -0.00 | sell |
| Patient Square Capital LP | 29,000 | 15,500 | -13,500 | 5.76 | 3.06 | -2.70 | sell |
| MML INVESTORS SERVICES, LLC | 15,380 | 15,379 | -1 | 0.02 | 0.03 | +0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 47,000 | 15,000 | -32,000 | 0.52 | 0.22 | -0.30 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 0 | 15,000 | +15,000 | 0.00 | 1.70 | +1.70 | buy |
| Mediolanum International Funds Ltd | 0 | 14,339 | +14,339 | 0.00 | 0.11 | +0.11 | buy |
| Erste Asset Management GmbH | 14,496 | 14,268 | -228 | 0.07 | 0.10 | +0.03 | sell |
| Tower Research Capital LLC (TRC) | 19,339 | 13,853 | -5,486 | 0.29 | 0.28 | -0.01 | sell |
| DCF Advisers, LLC | 13,650 | 13,650 | 0 | 3.62 | 3.81 | +0.19 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 6,164 | 13,600 | +7,436 | 0.01 | 0.03 | +0.02 | buy |