| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1,431,021 | 1,961,202 | +530,181 | 0.14 | 0.13 | -0.01 | buy |
| Artisan Partners Limited Partnership | 2,828,299 | 3,174,477 | +346,178 | 2.36 | 1.86 | -0.50 | buy |
| JANUS HENDERSON GROUP PLC | 1,471,138 | 1,776,759 | +305,621 | 0.48 | 0.41 | 0.00 | buy |
| Avoro Capital Advisors LLC | 1,000,000 | 1,234,567 | +234,567 | 7.67 | 6.49 | -1.18 | buy |
| T. Rowe Price Investment Management, Inc. | 966,356 | 1,182,121 | +215,765 | 0.34 | 0.29 | -0.04 | buy |
| Paradigm Biocapital Advisors LP | 261,443 | 422,577 | +161,134 | 8.77 | 7.53 | -1.23 | buy |
| RTW INVESTMENTS, LP | 507,195 | 667,195 | +160,000 | 5.26 | 3.96 | -1.30 | buy |
| Holocene Advisors, LP | 372,155 | 528,698 | +156,543 | 0.80 | 0.78 | -0.02 | buy |
| Alyeska Investment Group, L.P. | 115,131 | 234,836 | +119,705 | 0.38 | 0.59 | +0.21 | buy |
| ARMISTICE CAPITAL, LLC | 200,000 | 318,000 | +118,000 | 1.51 | 1.65 | +0.15 | buy |
| Clearbridge Investments, LLC | 344,364 | 436,797 | +92,433 | 0.16 | 0.14 | -0.02 | buy |
| Eversept Partners, LP | 4,565 | 85,832 | +81,267 | 0.19 | 2.87 | +2.68 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 92,237 | 165,393 | +73,156 | 0.13 | 0.18 | 0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 278,322 | 345,431 | +67,109 | 0.18 | 0.16 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 32,600 | 84,600 | +52,000 | 0.34 | 0.64 | +0.30 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,800 | 53,700 | +50,900 | 0.07 | 0.92 | +0.85 | buy |
| Saturn V Capital Management LP | 10,074 | 51,175 | +41,101 | 2.07 | 7.45 | +5.38 | buy |
| D. E. Shaw & Co., Inc. | 211,286 | 170,746 | +40,540 | 0.20 | 0.11 | 0.00 | sell |
| Hudson Bay Capital Management LP | 68,003 | 99,003 | +31,000 | 0.26 | 0.24 | -0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 81,112 | 111,048 | +29,936 | 0.10 | 0.09 | 0.00 | buy |
| Fairmount Funds Management LLC | 83,747 | 112,903 | +29,156 | 4.95 | 4.54 | -0.42 | buy |
| Eagle Health Investments LP | 64,400 | 84,590 | +20,190 | 6.98 | 6.54 | -0.44 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 127,136 | 146,168 | +19,032 | 0.09 | 0.08 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 175,371 | 193,885 | +18,514 | 0.10 | 0.07 | -0.03 | buy |
| Allspring Global Investments Holdings, LLC | 70,756 | 86,187 | +15,431 | 0.06 | 0.06 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,659,515 | 3,673,855 | +14,340 | 0.27 | 0.19 | -0.08 | buy |
| Legal & General Group Plc | 64,382 | 78,302 | +13,920 | 0.01 | 0.01 | -0.00 | buy |
| NATIXIS ADVISORS, LLC | 28,392 | 14,490 | +13,902 | 0.04 | 0.01 | 0.00 | sell |
| TimesSquare Capital Management, LLC | 101,750 | 112,705 | +10,955 | 0.78 | 0.63 | -0.15 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 581,586 | 591,666 | +10,080 | 0.10 | 0.07 | -0.03 | buy |
| ExodusPoint Capital Management, LP | 14,281 | 4,330 | +9,951 | 0.09 | 0.02 | 0.00 | sell |
| Tri Locum Partners LP | 14,346 | 24,182 | +9,836 | 2.26 | 4.52 | +2.25 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 16,000 | 25,000 | +9,000 | 0.15 | 0.16 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,227 | 10,027 | +8,800 | 0.12 | 1.64 | +1.53 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 36,323 | 44,651 | +8,328 | 0.23 | 0.20 | -0.03 | buy |
| CANADA LIFE ASSURANCE Co | 15,598 | 10,909 | +4,689 | 0.02 | 0.01 | -0.01 | sell |
| J. Goldman & Co LP | 1,350 | 5,092 | +3,742 | 0.02 | 0.08 | +0.06 | buy |
| FIRST TRUST ADVISORS LP | 83,023 | 79,777 | +3,246 | 0.05 | 0.03 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 105,951 | 108,951 | +3,000 | 0.12 | 0.09 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 761 | 3,719 | +2,958 | 0.11 | 0.28 | +0.17 | buy |
| Optiver Holding B.V. | 2,287 | 5,198 | +2,911 | 0.03 | 0.06 | +0.03 | buy |
| Monashee Investment Management LLC | 7,500 | 10,000 | +2,500 | 1.54 | 0.67 | -0.87 | buy |
| Atika Capital Management LLC | 24,695 | 26,695 | +2,000 | 1.59 | 1.36 | -0.23 | buy |
| PineBridge Investments, L.P. | 20,959 | 22,576 | +1,617 | 0.11 | 0.08 | -0.03 | buy |
| Orion Porfolio Solutions, LLC | 7,531 | 9,107 | +1,576 | 0.05 | 0.05 | 0.00 | buy |
| Fiera Capital Corp | 161,974 | 163,438 | +1,464 | 0.25 | 0.19 | -0.06 | buy |
| Bayesian Capital Management, LP | 1,085 | 2,385 | +1,300 | 0.06 | 0.10 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 14,381 | 13,188 | +1,193 | 0.01 | 0.01 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 4,490 | 3,336 | +1,154 | 0.00 | 0.00 | 0.00 | sell |
| TOWNSQUARE CAPITAL LLC | 3,442 | 4,448 | +1,006 | 0.03 | 0.03 | 0.00 | buy |
| Dorsey Wright & Associates | 4,140 | 5,136 | +996 | 0.63 | 0.59 | -0.04 | buy |
| Quantinno Capital Management LP | 1,689 | 1,035 | +654 | 0.04 | 0.01 | 0.00 | sell |
| EAGLE GLOBAL ADVISORS LLC | 4,600 | 5,200 | +600 | 0.15 | 0.12 | -0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 4,220 | 4,662 | +442 | 0.02 | 0.01 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 8,132 | 8,505 | +373 | 0.02 | 0.01 | -0.01 | buy |
| Atria Investments, Inc | 3,134 | 3,499 | +365 | 0.03 | 0.02 | -0.01 | buy |
| Marks Group Wealth Management, Inc | 725 | 1,034 | +309 | 0.04 | 0.04 | +0.00 | buy |
| USS Investment Management Ltd | 12,171 | 12,417 | +246 | 0.06 | 0.04 | -0.02 | buy |
| Main Street Financial Solutions, LLC | 685 | 924 | +239 | 0.05 | 0.05 | -0.00 | buy |
| PROFUND ADVISORS LLC | 907 | 1,077 | +170 | 0.02 | 0.02 | 0.00 | buy |
| CI INVESTMENTS INC. | 926 | 778 | +148 | 0.00 | 0.00 | 0.00 | sell |
| Gilbert & Cook, Inc. | 1,844 | 1,991 | +147 | 0.14 | 0.11 | -0.04 | buy |
| Portside Wealth Group, LLC | 512 | 641 | +129 | 0.05 | 0.05 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 2,656 | 2,764 | +108 | 0.02 | 0.01 | 0.00 | buy |
| ProShare Advisors LLC | 1,946 | 2,052 | +106 | 0.00 | 0.00 | 0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 1,730 | 1,832 | +102 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 1,000 | 1,100 | +100 | 0.01 | 0.01 | +0.00 | buy |
| Evolutionary Tree Capital Management, LLC | 3,393 | 3,474 | +81 | 2.15 | 1.46 | -0.69 | buy |
| MGO ONE SEVEN LLC | 477 | 549 | +72 | 0.02 | 0.01 | -0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 1,385 | 1,428 | +43 | 0.02 | 0.01 | 0.00 | buy |
| Wahed Invest LLC | 417 | 457 | +40 | 0.07 | 0.05 | -0.02 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 405 | 443 | +38 | 0.01 | 0.00 | -0.00 | buy |
| STEPH & CO | 302 | 325 | +23 | 0.08 | 0.06 | -0.02 | buy |
| FULTON BANK, N.A. | 539 | 560 | +21 | 0.01 | 0.01 | -0.00 | buy |
| Nemes Rush Group LLC | 20 | 28 | +8 | 0.00 | 0.00 | -0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 29 | 36 | +7 | 0.00 | 0.00 | 0.00 | buy |
| SYON CAPITAL LLC | 1,001 | 1,004 | +3 | 0.06 | 0.04 | -0.02 | buy |
| Prestige Wealth Management Group LLC | 4 | 6 | +2 | 0.00 | 0.00 | 0.00 | buy |
| Washington Trust Advisors, Inc. | 7 | 9 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Cornerstone Planning Group LLC | 34 | 35 | +1 | 0.01 | 0.00 | -0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 588 | 538 | -50 | 0.01 | 0.01 | -0.00 | sell |
| Laird Norton Wetherby Wealth Management, LLC | 1,426 | 1,348 | -78 | 0.04 | 0.03 | -0.01 | sell |
| EFG Asset Management (Americas) Corp. | 861 | 655 | -206 | 0.10 | 0.05 | -0.05 | sell |
| JGP Global Gestao de Recursos Ltda. | 1,275 | 996 | -279 | 0.40 | 0.23 | -0.17 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 1,950 | 1,650 | -300 | 0.09 | 0.05 | -0.03 | sell |
| OAK RIDGE INVESTMENTS LLC | 5,694 | 5,335 | -359 | 0.36 | 0.23 | -0.12 | sell |
| Legato Capital Management LLC | 1,640 | 1,154 | -486 | 0.12 | 0.06 | -0.06 | sell |
| BAMCO INC /NY/ | 287,991 | 287,379 | -612 | 0.41 | 0.29 | -0.12 | sell |
| Values First Advisors, Inc. | 3,059 | 2,061 | -998 | 0.97 | 0.47 | -0.50 | sell |
| GILDER GAGNON HOWE & CO LLC | 9,628 | 8,508 | -1,120 | 0.07 | 0.04 | -0.03 | sell |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 12,722 | 11,597 | -1,125 | 0.15 | 0.10 | -0.05 | sell |
| Simplify Asset Management Inc. | 3,038 | 1,778 | -1,260 | 0.25 | 0.10 | -0.14 | sell |
| ROYAL LONDON ASSET MANAGEMENT LTD | 47,735 | 46,333 | -1,402 | 0.08 | 0.05 | -0.03 | sell |
| EFG Asset Management (North America) Corp. | 10,115 | 8,625 | -1,490 | 1.18 | 0.62 | -0.56 | sell |
| DCF Advisers, LLC | 22,000 | 20,450 | -1,550 | 7.55 | 5.27 | -2.28 | sell |
| CLOUGH CAPITAL PARTNERS L P | 17,550 | 12,491 | -5,059 | 0.93 | 0.53 | -0.40 | sell |
| Artia Global Partners LP | 49,238 | 34,238 | -15,000 | 10.06 | 5.15 | -4.91 | sell |
| PFM Health Sciences, LP | 104,732 | 86,832 | -17,900 | 2.43 | 1.98 | -0.44 | sell |
| Rock Springs Capital Management LP | 259,000 | 229,250 | -29,750 | 3.41 | 2.15 | -1.26 | sell |
| Sofinnova Investments, Inc. | 78,186 | 44,721 | -33,465 | 2.42 | 0.95 | -1.47 | sell |