| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1,431,021 | 1,961,202 | +530,181 | 0.14 | 0.13 | -0.01 | buy |
| Artisan Partners Limited Partnership | 2,828,299 | 3,174,477 | +346,178 | 2.36 | 1.90 | -0.47 | buy |
| JANUS HENDERSON GROUP PLC | 1,471,138 | 1,776,759 | +305,621 | 0.47 | 0.40 | -0.07 | buy |
| EcoR1 Capital, LLC | 0 | 300,997 | +300,997 | 0.00 | 2.97 | +2.97 | buy |
| Deep Track Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 4.00 | +4.00 | buy |
| Avoro Capital Advisors LLC | 1,000,000 | 1,234,567 | +234,567 | 7.67 | 6.49 | -1.18 | buy |
| T. Rowe Price Investment Management, Inc. | 966,356 | 1,182,121 | +215,765 | 0.34 | 0.29 | -0.04 | buy |
| DEUTSCHE BANK AG\ | 6,978 | 189,405 | +182,427 | 0.00 | 0.04 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 261,443 | 422,577 | +161,134 | 8.77 | 7.53 | -1.23 | buy |
| RTW INVESTMENTS, LP | 507,195 | 667,195 | +160,000 | 5.26 | 3.96 | -1.30 | buy |
| Holocene Advisors, LP | 372,155 | 528,698 | +156,543 | 0.82 | 0.79 | -0.03 | buy |
| BRAIDWELL LP | 0 | 153,204 | +153,204 | 0.00 | 2.14 | +2.14 | buy |
| Logos Global Management LP | 0 | 145,000 | +145,000 | 0.00 | 6.13 | +6.13 | buy |
| Alyeska Investment Group, L.P. | 115,131 | 234,836 | +119,705 | 0.39 | 0.60 | +0.21 | buy |
| ARMISTICE CAPITAL, LLC | 200,000 | 318,000 | +118,000 | 2.92 | 3.21 | +0.29 | buy |
| Artal Group S.A. | 0 | 116,388 | +116,388 | 0.00 | 1.51 | +1.51 | buy |
| GOLDMAN SACHS GROUP INC | 153,633 | 252,369 | +98,736 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 554,910 | 652,887 | +97,977 | 0.03 | 0.02 | -0.01 | buy |
| Clearbridge Investments, LLC | 344,364 | 436,797 | +92,433 | 0.16 | 0.14 | -0.02 | buy |
| Assenagon Asset Management S.A. | 39,326 | 128,479 | +89,153 | 0.07 | 0.15 | +0.08 | buy |
| Eversept Partners, LP | 4,565 | 85,832 | +81,267 | 0.25 | 3.20 | +2.95 | buy |
| Aberdeen Group plc | 0 | 73,476 | +73,476 | 0.00 | 0.06 | +0.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 92,237 | 165,393 | +73,156 | 0.13 | 0.17 | +0.05 | buy |
| Ikarian Capital, LLC | 0 | 70,000 | +70,000 | 0.00 | 7.26 | +7.26 | buy |
| MILLENNIUM MANAGEMENT LLC | 278,322 | 345,431 | +67,109 | 0.14 | 0.12 | -0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 221,212 | 279,168 | +57,956 | 0.02 | 0.02 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 32,600 | 84,600 | +52,000 | 0.34 | 0.64 | +0.30 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,800 | 53,700 | +50,900 | 0.07 | 0.93 | +0.86 | buy |
| SEI INVESTMENTS CO | 286,310 | 332,017 | +45,707 | 0.25 | 0.20 | -0.05 | buy |
| Saturn V Capital Management LP | 10,074 | 51,175 | +41,101 | 2.07 | 7.45 | +5.38 | buy |
| Walleye Capital LLC | 0 | 39,751 | +39,751 | 0.00 | 0.21 | +0.21 | buy |
| Ally Bridge Group (NY) LLC | 0 | 35,000 | +35,000 | 0.00 | 7.93 | +7.93 | buy |
| Hudson Bay Capital Management LP | 68,003 | 99,003 | +31,000 | 0.32 | 0.33 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 81,112 | 111,048 | +29,936 | 0.09 | 0.08 | -0.01 | buy |
| Fairmount Funds Management LLC | 83,747 | 112,903 | +29,156 | 4.95 | 4.54 | -0.42 | buy |
| FEDERATED HERMES, INC. | 332,091 | 356,507 | +24,416 | 0.44 | 0.34 | -0.10 | buy |
| Eagle Health Investments LP | 64,400 | 84,590 | +20,190 | 6.98 | 6.54 | -0.44 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 127,136 | 146,168 | +19,032 | 0.09 | 0.08 | -0.01 | buy |
| Polar Asset Management Partners Inc. | 17,100 | 35,900 | +18,800 | 0.20 | 0.37 | +0.17 | buy |
| TD ASSET MANAGEMENT INC | 175,371 | 193,885 | +18,514 | 0.10 | 0.07 | -0.03 | buy |
| Squarepoint Ops LLC | 888 | 18,400 | +17,512 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,603 | +16,603 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 70,756 | 86,187 | +15,431 | 0.06 | 0.05 | -0.01 | buy |
| Lighthouse Investment Partners, LLC | 0 | 14,590 | +14,590 | 0.00 | 0.40 | +0.40 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,659,515 | 3,673,855 | +14,340 | 0.26 | 0.19 | -0.08 | buy |
| JANE STREET GROUP, LLC | 11,626 | 25,894 | +14,268 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 64,382 | 78,302 | +13,920 | 0.01 | 0.01 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 6,700 | 18,695 | +11,995 | 0.10 | 0.24 | +0.14 | buy |
| TimesSquare Capital Management, LLC | 101,750 | 112,705 | +10,955 | 0.78 | 0.63 | -0.15 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 581,586 | 591,666 | +10,080 | 0.10 | 0.07 | -0.03 | buy |
| Tri Locum Partners LP | 14,346 | 24,182 | +9,836 | 2.26 | 4.52 | +2.25 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 16,000 | 25,000 | +9,000 | 0.21 | 0.23 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,227 | 10,027 | +8,800 | 0.12 | 1.64 | +1.53 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 36,323 | 44,651 | +8,328 | 0.23 | 0.20 | -0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,934 | 38,460 | +7,526 | 0.01 | 0.01 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 7,500 | +7,500 | 0.00 | 0.57 | +0.57 | buy |
| HSBC HOLDINGS PLC | 9,436 | 15,698 | +6,262 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 430,787 | 436,233 | +5,446 | 0.06 | 0.04 | -0.02 | buy |
| VAN ECK ASSOCIATES CORP | 41,173 | 46,146 | +4,973 | 0.04 | 0.03 | -0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 4,826 | +4,826 | 0.00 | 0.57 | +0.57 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 4,538 | +4,538 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 43,887 | 47,900 | +4,013 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,616 | 47,583 | +3,967 | 0.01 | 0.01 | -0.00 | buy |
| J. Goldman & Co LP | 1,350 | 5,092 | +3,742 | 0.03 | 0.11 | +0.07 | buy |
| DAFNA Capital Management LLC | 0 | 3,600 | +3,600 | 0.00 | 0.33 | +0.33 | buy |
| Russell Investments Group, Ltd. | 26,346 | 29,836 | +3,490 | 0.03 | 0.02 | -0.01 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 3,211 | +3,211 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 105,951 | 108,951 | +3,000 | 0.12 | 0.09 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 761 | 3,719 | +2,958 | 0.11 | 0.28 | +0.17 | buy |
| Optiver Holding B.V. | 2,287 | 5,198 | +2,911 | 0.03 | 0.06 | +0.03 | buy |
| Monashee Investment Management LLC | 7,500 | 10,000 | +2,500 | 1.54 | 0.67 | -0.87 | buy |
| BARCLAYS PLC | 38,952 | 41,430 | +2,478 | 0.01 | 0.01 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 2,400 | +2,400 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 2,400 | +2,400 | 0.00 | 0.51 | +0.51 | buy |
| Walleye Trading LLC | 5,054 | 7,200 | +2,146 | 0.06 | 0.04 | -0.02 | buy |
| Atika Capital Management LLC | 24,695 | 26,695 | +2,000 | 1.73 | 1.44 | -0.29 | buy |
| Maryland State Retirement & Pension System | 0 | 1,928 | +1,928 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 1,147 | 3,061 | +1,914 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 16,059 | 17,878 | +1,819 | 0.00 | 0.00 | -0.00 | buy |
| PineBridge Investments, L.P. | 20,959 | 22,576 | +1,617 | 0.11 | 0.08 | -0.03 | buy |
| Orion Porfolio Solutions, LLC | 7,531 | 9,107 | +1,576 | 0.04 | 0.04 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 24,357 | 25,912 | +1,555 | 0.00 | 0.00 | -0.00 | buy |
| Maven Securities LTD | 0 | 1,500 | +1,500 | 0.00 | 0.07 | +0.07 | buy |
| Fiera Capital Corp | 161,974 | 163,438 | +1,464 | 0.25 | 0.19 | -0.06 | buy |
| NEOS Investment Management LLC | 0 | 1,352 | +1,352 | 0.00 | 0.05 | +0.05 | buy |
| Bayesian Capital Management, LP | 1,085 | 2,385 | +1,300 | 0.06 | 0.10 | +0.04 | buy |
| Legacy Wealth Asset Management, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.16 | +0.16 | buy |
| AdvisorShares Investments LLC | 0 | 1,278 | +1,278 | 0.00 | 0.11 | +0.11 | buy |
| ASSETMARK, INC | 4,365 | 5,638 | +1,273 | 0.01 | 0.01 | -0.00 | buy |
| Cinctive Capital Management LP | 0 | 1,195 | +1,195 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 1,104 | +1,104 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 0 | 1,084 | +1,084 | 0.00 | 0.07 | +0.07 | buy |
| Jefferies Financial Group Inc. | 2,000 | 3,021 | +1,021 | 0.02 | 0.02 | -0.01 | buy |
| TOWNSQUARE CAPITAL LLC | 3,442 | 4,448 | +1,006 | 0.03 | 0.03 | -0.00 | buy |
| Dorsey Wright & Associates | 4,140 | 5,136 | +996 | 0.63 | 0.59 | -0.04 | buy |
| Woodline Partners LP | 0 | 993 | +993 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 881 | +881 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 1,931 | 2,786 | +855 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 24,212 | 25,023 | +811 | 0.00 | 0.00 | -0.00 | buy |
| Ramirez Asset Management, Inc. | 0 | 772 | +772 | 0.00 | 0.06 | +0.06 | buy |