| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,692,346 | 5,592,319 | -100,027 | 0.22 | 0.24 | +0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,640,409 | 3,362,324 | -278,085 | 0.29 | 0.30 | +0.02 | sell |
| JANUS HENDERSON GROUP PLC | 2,575,251 | 2,458,164 | -117,087 | 0.87 | 0.92 | +0.05 | sell |
| Capital World Investors | 1,959,504 | 1,916,234 | -43,270 | 0.20 | 0.22 | +0.02 | sell |
| Artisan Partners Limited Partnership | 2,186,510 | 1,756,942 | -429,568 | 2.32 | 2.26 | -0.06 | sell |
| Avoro Capital Advisors LLC | 990,000 | 990,000 | 0 | 9.45 | 8.18 | -1.26 | hold |
| BlackRock, Inc. | 523,801 | 735,598 | +211,797 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 729,986 | 679,236 | -50,750 | 0.09 | 0.10 | +0.01 | sell |
| RTW INVESTMENTS, LP | 673,497 | 673,497 | 0 | 6.12 | 5.67 | -0.45 | hold |
| MORGAN STANLEY | 435,106 | 518,852 | +83,746 | 0.02 | 0.03 | +0.01 | buy |
| Clearbridge Investments, LLC | 756,862 | 513,764 | -243,098 | 0.42 | 0.35 | -0.07 | sell |
| Bellevue Group AG | 546,328 | 461,854 | -84,474 | 8.37 | 7.36 | -1.01 | sell |
| Invesco Ltd. | 84,919 | 416,408 | +331,489 | 0.01 | 0.04 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 84,753 | 414,182 | +329,429 | 0.02 | 0.11 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 342,379 | 400,776 | +58,397 | 0.02 | 0.02 | +0.01 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 16,625 | 356,870 | +340,245 | 0.03 | 0.91 | +0.88 | buy |
| CITADEL ADVISORS LLC | 713,559 | 350,851 | -362,708 | 0.42 | 0.20 | -0.22 | sell |
| SEI INVESTMENTS CO | 312,268 | 330,506 | +18,238 | 0.25 | 0.27 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 294,160 | 258,556 | -35,604 | 0.33 | 0.32 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 258,274 | 237,701 | -20,573 | 0.05 | 0.05 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 240,228 | 229,761 | -10,467 | 0.10 | 0.12 | +0.01 | sell |
| Fiera Capital Corp | 177,654 | 225,971 | +48,317 | 0.42 | 0.60 | +0.18 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 223,666 | +223,666 | 0.00 | 0.52 | +0.52 | buy |
| AMERICAN CENTURY COMPANIES INC | 229,770 | 221,048 | -8,722 | 0.09 | 0.09 | +0.01 | sell |
| LORD, ABBETT & CO. LLC | 196,877 | 203,864 | +6,987 | 0.43 | 0.53 | +0.09 | buy |
| AMERIPRISE FINANCIAL INC | 165,658 | 187,139 | +21,481 | 0.03 | 0.04 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 211,330 | 172,732 | -38,598 | 0.26 | 0.24 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 21,610 | 169,098 | +147,488 | 0.02 | 0.14 | +0.12 | buy |
| GOLDMAN SACHS GROUP INC | 193,113 | 167,206 | -25,907 | 0.02 | 0.02 | -0.00 | sell |
| BAMCO INC /NY/ | 167,694 | 153,719 | -13,975 | 0.33 | 0.35 | +0.02 | sell |
| Pictet Asset Management Holding SA | 169,333 | 153,211 | -16,122 | 0.12 | 0.13 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 172,300 | 146,000 | -26,300 | 3.05 | 2.51 | -0.54 | sell |
| Legal & General Group Plc | 148,619 | 144,355 | -4,264 | 0.02 | 0.03 | +0.00 | sell |
| Checkpoint Capital L.P. | 150,000 | 142,000 | -8,000 | 37.07 | 37.83 | +0.77 | sell |
| TWO SIGMA ADVISERS, LP | 139,700 | 135,500 | -4,200 | 0.21 | 0.22 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 88,724 | 134,710 | +45,986 | 0.02 | 0.04 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 137,196 | 133,030 | -4,166 | 0.14 | 0.19 | +0.05 | sell |
| AGF MANAGEMENT LTD | 0 | 124,691 | +124,691 | 0.00 | 0.45 | +0.45 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 125,371 | 121,221 | -4,150 | 1.52 | 1.59 | +0.07 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 62,804 | 117,887 | +55,083 | 0.08 | 0.16 | +0.08 | buy |
| BNP Paribas Asset Management Holding S.A. | 80,632 | 115,358 | +34,726 | 0.15 | 0.11 | -0.04 | buy |
| 1832 Asset Management L.P. | 110,700 | 110,700 | 0 | 0.14 | 0.12 | -0.02 | hold |
| TimesSquare Capital Management, LLC | 127,530 | 108,509 | -19,021 | 1.35 | 1.37 | +0.03 | sell |
| FEDERATED HERMES, INC. | 124,224 | 106,770 | -17,454 | 0.16 | 0.15 | -0.01 | sell |
| Rock Springs Capital Management LP | 142,750 | 103,250 | -39,500 | 6.15 | 4.45 | -1.70 | sell |
| TD ASSET MANAGEMENT INC | 120,902 | 101,523 | -19,379 | 0.07 | 0.07 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 96,361 | 90,452 | -5,909 | 0.12 | 0.13 | +0.02 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 92,454 | 82,620 | -9,834 | 2.22 | 1.95 | -0.27 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 95,711 | 79,989 | -15,722 | 0.02 | 0.02 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 106,714 | 70,744 | -35,970 | 0.06 | 0.04 | -0.02 | sell |
| Nuveen, LLC | 81,400 | 66,241 | -15,159 | 0.02 | 0.01 | -0.00 | sell |
| Artia Global Partners LP | 78,311 | 64,699 | -13,612 | 10.16 | 8.74 | -1.42 | sell |
| NORTHERN TRUST CORP | 69,751 | 64,244 | -5,507 | 0.01 | 0.01 | +0.00 | sell |
| Eagle Health Investments LP | 77,430 | 62,730 | -14,700 | 14.99 | 11.59 | -3.40 | sell |
| BESSEMER GROUP INC | 64 | 62,537 | +62,473 | 0.00 | 0.08 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 347,518 | 60,458 | -287,060 | 0.20 | 0.04 | -0.17 | sell |
| UBS Group AG | 53,793 | 60,384 | +6,591 | 0.01 | 0.01 | +0.00 | buy |
| Jain Global LLC | 2,264 | 58,250 | +55,986 | 0.02 | 0.48 | +0.46 | buy |
| ARMISTICE CAPITAL, LLC | 58,000 | 58,000 | 0 | 1.34 | 1.19 | -0.15 | hold |
| RAYMOND JAMES FINANCIAL INC | 68,794 | 57,489 | -11,305 | 0.02 | 0.02 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,286 | 57,408 | -7,878 | 0.04 | 0.04 | -0.00 | sell |
| PGGM Investments | 76,699 | 54,830 | -21,869 | 0.92 | 0.73 | -0.19 | sell |
| WELLS FARGO & COMPANY/MN | 55,674 | 54,390 | -1,284 | 0.01 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 64,985 | 53,902 | -11,083 | 0.04 | 0.03 | -0.00 | sell |
| Handelsbanken Fonder AB | 41,105 | 52,678 | +11,573 | 0.10 | 0.13 | +0.04 | buy |
| Aberdeen Group plc | 66,676 | 52,347 | -14,329 | 0.08 | 0.07 | -0.01 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 13,600 | 49,358 | +35,758 | 0.03 | 0.11 | +0.08 | buy |
| Candriam S.C.A. | 48,200 | 48,741 | +541 | 0.19 | 0.20 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 169,028 | 45,533 | -123,495 | 0.10 | 0.03 | -0.07 | sell |
| Woodline Partners LP | 169,476 | 45,426 | -124,050 | 0.59 | 0.15 | -0.44 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 65,122 | 44,027 | -21,095 | 0.06 | 0.05 | -0.01 | sell |
| Amundi | 8,181 | 42,485 | +34,304 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 41,923 | +41,923 | 0.00 | 0.07 | +0.07 | buy |
| Tri Locum Partners LP | 43,411 | 37,653 | -5,758 | 7.36 | 4.11 | -3.25 | sell |
| DIMENSIONAL FUND ADVISORS LP | 40,220 | 36,817 | -3,403 | 0.01 | 0.01 | +0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 36,600 | +36,600 | 0.00 | 0.10 | +0.10 | buy |
| ROYAL BANK OF CANADA | 47,064 | 35,660 | -11,404 | 0.01 | 0.01 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 36,071 | 34,535 | -1,536 | 0.02 | 0.02 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 33,847 | +33,847 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 69,426 | 31,726 | -37,700 | 2.74 | 1.13 | -1.60 | sell |
| BRAIDWELL LP | 76,091 | 31,007 | -45,084 | 1.67 | 0.83 | -0.83 | sell |
| Perpetual Ltd | 49,379 | 30,950 | -18,429 | 0.45 | 0.38 | -0.08 | sell |
| Jefferies Financial Group Inc. | 155,000 | 30,000 | -125,000 | 1.05 | 0.21 | -0.84 | sell |
| JANE STREET GROUP, LLC | 49,904 | 28,485 | -21,419 | 0.04 | 0.03 | -0.01 | sell |
| Squarepoint Ops LLC | 18,985 | 28,202 | +9,217 | 0.03 | 0.05 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 2,383 | 26,340 | +23,957 | 0.00 | 0.06 | +0.05 | buy |
| Patient Square Capital LP | 15,500 | 26,000 | +10,500 | 3.06 | 4.68 | +1.62 | buy |
| LPL Financial LLC | 25,770 | 25,656 | -114 | 0.01 | 0.01 | +0.00 | sell |
| Quadrature Capital Ltd | 50,603 | 25,399 | -25,204 | 0.44 | 0.22 | -0.22 | sell |
| BAKER BROS. ADVISORS LP | 37,760 | 25,174 | -12,586 | 0.20 | 0.12 | -0.08 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 15,000 | 25,000 | +10,000 | 0.22 | 0.43 | +0.21 | buy |
| Assenagon Asset Management S.A. | 0 | 24,347 | +24,347 | 0.00 | 0.03 | +0.03 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 15,000 | 24,000 | +9,000 | 1.70 | 2.57 | +0.87 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 23,959 | +23,959 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 26,114 | 23,695 | -2,419 | 0.00 | 0.00 | +0.00 | sell |
| ODDO BHF ASSET MANAGEMENT SAS | 28,889 | 23,473 | -5,416 | 0.81 | 0.74 | -0.07 | sell |
| First Turn Management, LLC | 38,767 | 23,256 | -15,511 | 4.29 | 2.23 | -2.06 | sell |
| NATIXIS ADVISORS, LLC | 24,503 | 22,500 | -2,003 | 0.03 | 0.03 | +0.00 | sell |
| Qube Research & Technologies Ltd | 35,183 | 22,451 | -12,732 | 0.04 | 0.03 | -0.01 | sell |
| Hudson Bay Capital Management LP | 10,500 | 21,822 | +11,322 | 0.05 | 0.11 | +0.06 | buy |