| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 1,022,797 | +1,022,797 | 0.00 | 2.00 | +2.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,349,000 | 2,342,684 | +993,684 | 0.45 | 1.04 | +0.59 | buy |
| MORGAN STANLEY | 923,040 | 1,511,687 | +588,647 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,316,977 | 1,827,523 | +510,546 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 2,464,712 | 2,958,246 | +493,534 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,630,125 | 2,085,333 | +455,208 | 0.70 | 1.05 | +0.35 | buy |
| Alyeska Investment Group, L.P. | 0 | 442,500 | +442,500 | 0.00 | 0.11 | +0.11 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 428,266 | +428,266 | 0.00 | 0.38 | +0.38 | buy |
| BANK OF AMERICA CORP /DE/ | 335,365 | 708,503 | +373,138 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 237,342 | +237,342 | 0.00 | 0.37 | +0.37 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,700 | 210,768 | +179,068 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 365,032 | 536,986 | +171,954 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 46,649 | 216,793 | +170,144 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,816,993 | 1,980,783 | +163,790 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 156,263 | +156,263 | 0.00 | 0.58 | +0.58 | buy |
| BRAIDWELL LP | 0 | 142,755 | +142,755 | 0.00 | 0.39 | +0.39 | buy |
| FRANKLIN RESOURCES INC | 4,606 | 146,135 | +141,529 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 108,325 | +108,325 | 0.00 | 0.01 | +0.01 | buy |
| Blue Water Life Science Advisors, LP | 0 | 99,000 | +99,000 | 0.00 | 5.32 | +5.32 | buy |
| RAYMOND JAMES FINANCIAL INC | 160,203 | 258,810 | +98,607 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 86,613 | +86,613 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 61,575 | 147,906 | +86,331 | 0.09 | 0.27 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 730,250 | 801,503 | +71,253 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 67,427 | +67,427 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 55,855 | +55,855 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 108,792 | 163,244 | +54,452 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 50,508 | +50,508 | 0.00 | 0.19 | +0.19 | buy |
| WIM INVESTMENT MANAGEMENT Ltd | 63,000 | 106,400 | +43,400 | 0.95 | 2.35 | +1.41 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 38,495 | +38,495 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 3,600 | 40,926 | +37,326 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 94,006 | 125,658 | +31,652 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 0 | 31,074 | +31,074 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 10,493 | 41,016 | +30,523 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 29,692 | +29,692 | 0.00 | 0.28 | +0.28 | buy |
| GILDER GAGNON HOWE & CO LLC | 17,498 | 43,722 | +26,224 | 0.01 | 0.04 | +0.03 | buy |
| Blackstone Inc. | 0 | 23,036 | +23,036 | 0.00 | 0.01 | +0.01 | buy |
| Banque Transatlantique SA | 0 | 23,000 | +23,000 | 0.00 | 0.05 | +0.05 | buy |
| PRUDENTIAL FINANCIAL INC | 4,310 | 25,095 | +20,785 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 251,492 | 270,827 | +19,335 | 0.00 | 0.00 | +0.00 | buy |
| Slow Capital, Inc. | 143,840 | 162,417 | +18,577 | 1.00 | 1.66 | +0.66 | buy |
| Rafferty Asset Management, LLC | 43,009 | 61,284 | +18,275 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 49,691 | 67,534 | +17,843 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 30,975 | 47,528 | +16,553 | 0.01 | 0.02 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 16,051 | +16,051 | 0.00 | 0.04 | +0.04 | buy |
| Man Group plc | 0 | 15,225 | +15,225 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 66,408 | 81,476 | +15,068 | 0.00 | 0.00 | +0.00 | buy |
| Bouvel Investment Partners, LLC | 0 | 15,061 | +15,061 | 0.00 | 0.37 | +0.37 | buy |
| IMC-Chicago, LLC | 0 | 14,971 | +14,971 | 0.00 | 0.02 | +0.02 | buy |
| CreativeOne Wealth, LLC | 0 | 14,808 | +14,808 | 0.00 | 0.03 | +0.03 | buy |
| Legato Capital Management LLC | 0 | 13,435 | +13,435 | 0.00 | 0.10 | +0.10 | buy |
| PROFUND ADVISORS LLC | 9,442 | 22,776 | +13,334 | 0.02 | 0.06 | +0.04 | buy |
| Swiss National Bank | 59,300 | 72,300 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal Advantage Investments, Inc. | 21,000 | 33,500 | +12,500 | 0.56 | 1.33 | +0.77 | buy |
| State of New Jersey Common Pension Fund D | 0 | 12,499 | +12,499 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7,055 | 18,308 | +11,253 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,202 | 65,336 | +11,134 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 11,000 | +11,000 | 0.00 | 0.04 | +0.04 | buy |
| Rockefeller Capital Management L.P. | 58,012 | 68,577 | +10,565 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 27,924 | 37,765 | +9,841 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 9,400 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 8,887 | +8,887 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 10,920 | 19,565 | +8,645 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,296 | 11,096 | +7,800 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 3,663 | 11,378 | +7,715 | 0.00 | 0.01 | +0.01 | buy |
| Magnetar Financial LLC | 0 | 7,630 | +7,630 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 6,973 | +6,973 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 4,903 | 11,320 | +6,417 | 0.00 | 0.02 | +0.01 | buy |
| Mariner, LLC | 15,503 | 21,759 | +6,256 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 5,761 | +5,761 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 5,700 | +5,700 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 5,670 | +5,670 | 0.00 | 0.01 | +0.01 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 5,626 | +5,626 | 0.00 | 0.01 | +0.01 | buy |
| Green Alpha Advisors, LLC | 0 | 5,311 | +5,311 | 0.00 | 0.42 | +0.42 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,196 | 19,398 | +5,202 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,612 | 34,774 | +5,162 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 5,066 | +5,066 | 0.00 | 0.01 | +0.01 | buy |
| LEVEL FOUR ADVISORY SERVICES, LLC | 0 | 5,055 | +5,055 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 17,955 | 23,002 | +5,047 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 130,907 | 135,808 | +4,901 | 0.00 | 0.00 | +0.00 | buy |
| BURNEY CO/ | 0 | 4,808 | +4,808 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 5,546 | 10,202 | +4,656 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 15,756 | 20,200 | +4,444 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 4,430 | +4,430 | 0.00 | 0.03 | +0.03 | buy |
| Robertson Stephens Wealth Management, LLC | 0 | 4,328 | +4,328 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 4,326 | +4,326 | 0.00 | 0.01 | +0.01 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 4,193 | +4,193 | 0.00 | 0.02 | +0.02 | buy |
| Regal Partners Ltd | 0 | 4,000 | +4,000 | 0.00 | 0.02 | +0.02 | buy |
| JONES FINANCIAL COMPANIES LLLP | 4,509 | 8,311 | +3,802 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 0 | 3,673 | +3,673 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 3,541 | +3,541 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 12,500 | 16,000 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 5,783 | 9,274 | +3,491 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 6,634 | 10,025 | +3,391 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 7,508 | 10,796 | +3,288 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,640 | 19,898 | +3,258 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 67,634 | 70,850 | +3,216 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 3,207 | +3,207 | 0.00 | 0.00 | +0.00 | buy |
| WELCH & FORBES LLC | 0 | 3,108 | +3,108 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 3,028 | +3,028 | 0.00 | 0.02 | +0.02 | buy |
| CIBC Asset Management Inc | 4,583 | 7,556 | +2,973 | 0.00 | 0.00 | +0.00 | buy |