| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6,475,291 | 6,475,291 | 0 | 0.40 | 0.20 | -0.20 | hold |
| ArrowMark Colorado Holdings LLC | 2,714,143 | 3,198,756 | +484,613 | 0.09 | 0.06 | -0.03 | buy |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 0.92 | 0.57 | -0.34 | hold |
| VANGUARD GROUP INC | 2,405,307 | 2,452,111 | +46,804 | 0.00 | 0.00 | -0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 2,345,361 | 2,345,361 | 0 | 0.05 | 0.02 | -0.03 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 768,449 | 2,080,194 | +1,311,745 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,230,350 | 1,580,550 | +350,200 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,439,841 | 1,367,915 | -71,926 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 0 | 1,306,490 | +1,306,490 | 0.00 | 1.49 | +1.49 | buy |
| PFM Health Sciences, LP | 1,473,013 | 1,275,462 | -197,551 | 0.27 | 0.11 | -0.17 | sell |
| GOLDMAN SACHS GROUP INC | 802,875 | 1,095,250 | +292,375 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 860,336 | 903,137 | +42,801 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 429,642 | 826,704 | +397,062 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 723,454 | 785,990 | +62,536 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 248,505 | 720,635 | +472,130 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 655,461 | +655,461 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 566,879 | 566,879 | 0 | 0.05 | 0.02 | -0.02 | hold |
| PERSONAL CFO SOLUTIONS, LLC | 550,342 | 550,342 | 0 | 0.30 | 0.15 | -0.15 | hold |
| CITIGROUP INC | 520,607 | 522,723 | +2,116 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 517,364 | 493,550 | -23,814 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 0 | 471,481 | +471,481 | 0.00 | 0.17 | +0.17 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 185,123 | 433,853 | +248,730 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 278,701 | 399,710 | +121,009 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 188,600 | 365,400 | +176,800 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 0 | 351,875 | +351,875 | 0.00 | 0.30 | +0.30 | buy |
| NORTHERN TRUST CORP | 327,224 | 338,134 | +10,910 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 322,024 | 322,024 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 557,471 | 272,859 | -284,612 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258,527 | 265,924 | +7,397 | 0.00 | 0.00 | -0.00 | buy |
| M&T BANK CORP | 197,682 | 258,484 | +60,802 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 750,153 | 205,855 | -544,298 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 1,580,487 | 200,938 | -1,379,549 | 0.05 | 0.00 | -0.05 | sell |
| Shay Capital LLC | 0 | 197,178 | +197,178 | 0.00 | 0.10 | +0.10 | buy |
| XTX Topco Ltd | 249,412 | 195,006 | -54,406 | 0.17 | 0.04 | -0.12 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 152,391 | +152,391 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 141,788 | 141,788 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 127,868 | 133,624 | +5,756 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 131,845 | +131,845 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,930,340 | 119,269 | -3,811,071 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 125,487 | 117,101 | -8,386 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 157,645 | 114,975 | -42,670 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 114,432 | +114,432 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 30,000 | 80,000 | +50,000 | 0.01 | 0.02 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,900 | 75,000 | -119,900 | 0.01 | 0.00 | -0.01 | sell |
| Assenagon Asset Management S.A. | 70,814 | 70,814 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marquette Asset Management, LLC | 0 | 64,009 | +64,009 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 59,748 | 62,728 | +2,980 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 41,065 | 58,249 | +17,184 | 0.02 | 0.01 | -0.01 | buy |
| State of Wyoming | 16,798 | 58,089 | +41,291 | 0.01 | 0.02 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 126,000 | 56,852 | -69,148 | 0.01 | 0.00 | -0.01 | sell |
| Walleye Capital LLC | 50,398 | 50,665 | +267 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,500 | 50,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 44,648 | 50,087 | +5,439 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 125,380 | 49,794 | -75,586 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 39,079 | 43,713 | +4,634 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,944 | 42,802 | +17,858 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 39,637 | +39,637 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,500 | 31,100 | +7,600 | 0.01 | 0.00 | -0.00 | buy |
| Amundi | 26,182 | 26,182 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 25,030 | 25,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,300 | 22,757 | +14,457 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 19,169 | 20,217 | +1,048 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 18,705 | +18,705 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 6,179 | 15,850 | +9,671 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 15,492 | +15,492 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 32,100 | 15,130 | -16,970 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 15,616 | 14,180 | -1,436 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,882 | 14,020 | -2,862 | 0.00 | 0.00 | -0.00 | sell |
| Independent Advisor Alliance | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 11,533 | 11,533 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Belvedere Trading LLC | 0 | 11,419 | +11,419 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,986 | 11,315 | -671 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 14,218 | 10,415 | -3,803 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,952 | 10,240 | +5,288 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,223 | 10,161 | -62 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quantbot Technologies LP | 5,336 | 5,336 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 9,508 | 4,646 | -4,862 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,348 | 4,124 | -2,224 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,772 | 3,772 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 703,338 | 3,624 | -699,714 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 3,468 | 3,468 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 2,316 | 2,527 | +211 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 1,616 | 1,616 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 3,431 | 1,279 | -2,152 | 0.00 | 0.00 | -0.00 | sell |
| Private Wealth Management Group, LLC | 676 | 676 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avion Wealth | 0 | 299 | +299 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 165 | +165 | 0.00 | 0.00 | 0.00 | buy |
| Avior Wealth Management, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 72,683 | 0 | -72,683 | 0.00 | 0.00 | -0.00 | sell |
| DENALI ADVISORS LLC | 33,900 | 0 | -33,900 | 0.03 | 0.00 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 685,985 | 0 | -685,985 | 0.92 | 0.00 | -0.92 | sell |
| SG Americas Securities, LLC | 20,994 | 0 | -20,994 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 22,915 | 0 | -22,915 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 15,442 | 0 | -15,442 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 685,985 | 0 | -685,985 | 0.02 | 0.00 | -0.02 | sell |
| Aristides Capital LLC | 31,145 | 0 | -31,145 | 0.05 | 0.00 | -0.05 | sell |
| NewEdge Advisors, LLC | 31 | 0 | -31 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 11,221 | 0 | -11,221 | 0.00 | 0.00 | -0.00 | sell |