| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PFM Health Sciences, LP | 2,079,245 | 3,301,942 | +1,222,697 | 0.24 | 0.28 | +0.04 | buy |
| BML Capital Management, LLC | 3,466,684 | 3,747,612 | +280,928 | 3.25 | 3.31 | +0.05 | buy |
| Sio Capital Management, LLC | 3,572,167 | 3,735,396 | +163,229 | 1.52 | 1.23 | -0.28 | buy |
| Stonepine Capital Management, LLC | 535,805 | 630,183 | +94,378 | 0.65 | 0.67 | +0.02 | buy |
| Peapod Lane Capital LLC | 445,744 | 489,370 | +43,626 | 0.67 | 0.60 | -0.07 | buy |
| VANGUARD GROUP INC | 2,143,102 | 2,175,061 | +31,959 | 0.00 | 0.00 | -0.00 | buy |
| Aldebaran Capital, LLC | 502,190 | 523,553 | +21,363 | 0.72 | 0.54 | -0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 421,710 | 430,792 | +9,082 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 107,340 | 107,346 | +6 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 6,475,291 | 6,475,291 | 0 | 0.20 | 0.17 | -0.03 | hold |
| RBF Capital, LLC | 245,561 | 245,561 | 0 | 0.02 | 0.02 | -0.00 | hold |
| EVOKE WEALTH, LLC | 133,122 | 133,122 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 0.54 | 1.08 | +0.54 | hold |
| Velan Capital Investment Management LP | 35,000 | 35,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| ADAR1 Capital Management, LLC | 101,008 | 101,008 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Corient Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 30,197 | 30,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 126,004 | 126,004 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,600 | 33,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 89,631 | 89,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 157,578 | 157,578 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Independent Advisor Alliance | 12,514 | 12,500 | -14 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 105 | 0 | -105 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 763 | 544 | -219 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,525 | 720 | -805 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,005 | 0 | -1,005 | 0.00 | 0.00 | -0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 2,343,731 | 2,342,373 | -1,358 | 0.02 | 0.02 | -0.01 | sell |
| BlackRock, Inc. | 1,146,484 | 1,144,396 | -2,088 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,595 | 0 | -2,595 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 4,938 | 2,092 | -2,846 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 14,983 | 11,296 | -3,687 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 4,034 | 0 | -4,034 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 22,807 | 18,007 | -4,800 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 69,113 | 62,134 | -6,979 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 39,080 | 30,891 | -8,189 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 10,877 | 0 | -10,877 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 11,014 | 0 | -11,014 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 35,200 | 22,900 | -12,300 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 13,300 | 0 | -13,300 | 0.02 | 0.00 | -0.02 | sell |
| SIMPLEX TRADING, LLC | 16,935 | 0 | -16,935 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 24,880 | 0 | -24,880 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 127,626 | 101,696 | -25,930 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28,700 | 0 | -28,700 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 121,245 | 90,263 | -30,982 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 2,078,866 | 2,047,177 | -31,689 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 32,603 | 0 | -32,603 | 0.01 | 0.00 | -0.01 | sell |
| Assenagon Asset Management S.A. | 153,701 | 115,038 | -38,663 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 73,015 | 21,896 | -51,119 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 202,100 | 148,800 | -53,300 | 0.01 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 64,009 | 0 | -64,009 | 0.02 | 0.00 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 1,024,288 | 949,726 | -74,562 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 370,920 | 267,636 | -103,284 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 107,888 | 0 | -107,888 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 506,986 | 353,227 | -153,759 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 156,451 | 0 | -156,451 | 0.06 | 0.00 | -0.06 | sell |
| MILLENNIUM MANAGEMENT LLC | 318,020 | 155,389 | -162,631 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 3,508,451 | 3,308,677 | -199,774 | 0.07 | 0.06 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 714,600 | 505,600 | -209,000 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 275,464 | 0 | -275,464 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 322,024 | 0 | -322,024 | 0.01 | 0.00 | -0.01 | sell |
| M&T BANK CORP | 399,548 | 0 | -399,548 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 539,893 | 129,914 | -409,979 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 514,911 | 19,310 | -495,601 | 0.00 | 0.00 | -0.00 | sell |