| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 5,292,000 | 5,320,000 | +28,000 | 5.86 | 4.24 | -1.61 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,940,000 | 4,245,085 | -694,915 | 0.31 | 0.27 | -0.04 | sell |
| Sio Capital Management, LLC | 2,636,548 | 3,076,580 | +440,032 | 0.55 | 0.55 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 3,090,093 | 2,872,764 | -217,329 | 0.08 | 0.09 | +0.01 | sell |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 0.89 | 0.83 | -0.06 | hold |
| Eversept Partners, LP | 0 | 2,348,360 | +2,348,360 | 0.00 | 0.19 | +0.19 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,015,770 | 2,215,894 | +200,124 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 706,061 | 1,884,530 | +1,178,469 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,860,000 | +1,860,000 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,094,883 | 874,374 | -220,509 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 1,150,759 | 708,102 | -442,657 | 1.14 | 0.77 | -0.37 | sell |
| Longaeva Partners L.P. | 0 | 552,027 | +552,027 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 446,140 | 495,922 | +49,782 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 477,988 | 473,362 | -4,626 | 0.54 | 0.45 | -0.09 | sell |
| MARSHALL WACE, LLP | 465,086 | 434,093 | -30,993 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 428,853 | 428,853 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Assenagon Asset Management S.A. | 140,468 | 360,786 | +220,318 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 335,694 | 335,694 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 101,008 | 231,008 | +130,000 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 183,178 | 183,178 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 524,350 | 179,873 | -344,477 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 162,200 | 162,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| EVOKE WEALTH, LLC | 133,122 | 133,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BIT Capital GmbH | 0 | 123,555 | +123,555 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 382,088 | 115,422 | -266,666 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 89,136 | 89,136 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Velan Capital Investment Management LP | 35,000 | 73,000 | +38,000 | 0.03 | 0.06 | +0.03 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 73,211 | 68,292 | -4,919 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 45,500 | 66,846 | +21,346 | 0.05 | 0.09 | +0.04 | buy |
| Quadrature Capital Ltd | 18,428 | 61,174 | +42,746 | 0.00 | 0.00 | +0.00 | buy |
| Accurate Wealth Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 62,020 | 41,590 | -20,430 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 32,460 | +32,460 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 30,891 | 30,891 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 27,536 | 27,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 26,502 | 27,381 | +879 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 27,126 | 27,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 28,744 | 20,945 | -7,799 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,434 | 19,734 | -7,700 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 19,296 | 19,296 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pathstone Holdings, LLC | 17,487 | 17,487 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 15,441 | +15,441 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 12,842 | 14,050 | +1,208 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 65,114 | 13,237 | -51,877 | 0.00 | 0.00 | -0.00 | sell |
| Sand Hill Global Advisors, LLC | 0 | 12,539 | +12,539 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GTS SECURITIES LLC | 10,002 | 10,001 | -1 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,790 | 8,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 27,862 | 8,181 | -19,681 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,905 | 1,365 | -2,540 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 518 | 539 | +21 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,975,291 | 0 | -4,975,291 | 0.13 | 0.00 | -0.13 | sell |
| TWO SIGMA SECURITIES, LLC | 23,369 | 0 | -23,369 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 874,100 | 0 | -874,100 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 16,607 | 0 | -16,607 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 498,641 | 0 | -498,641 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 104,485 | 0 | -104,485 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 17,069 | 0 | -17,069 | 0.00 | 0.00 | -0.00 | sell |