| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 3,747,612 | 5,000,000 | +1,252,388 | 3.31 | 4.06 | +0.75 | buy |
| CITADEL ADVISORS LLC | 0 | 256,431 | +256,431 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 630,183 | 845,968 | +215,785 | 0.67 | 0.88 | +0.21 | buy |
| Assenagon Asset Management S.A. | 115,038 | 263,059 | +148,021 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 24,310 | +24,310 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 22,437 | +22,437 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,047,177 | 2,066,137 | +18,960 | 0.01 | 0.00 | -0.00 | buy |
| Pathstone Holdings, LLC | 0 | 17,487 | +17,487 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 8,790 | +8,790 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 107,346 | 115,657 | +8,311 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 90,263 | 95,073 | +4,810 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 720 | 3,688 | +2,968 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 430,792 | 432,704 | +1,912 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 71 | +71 | 0.00 | 0.00 | 0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,016 | +16 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 544 | 545 | +1 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 6,475,291 | 6,475,291 | 0 | 0.17 | 0.17 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 148,800 | 148,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 245,561 | 245,561 | 0 | 0.02 | 0.01 | -0.00 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 2,342,373 | 2,342,373 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Sio Capital Management, LLC | 3,735,396 | 3,735,396 | 0 | 1.23 | 1.59 | +0.36 | hold |
| Independent Advisor Alliance | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EVOKE WEALTH, LLC | 133,122 | 133,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 1.08 | 0.91 | -0.17 | hold |
| Velan Capital Investment Management LP | 35,000 | 35,000 | 0 | 0.04 | 0.04 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 101,008 | 101,008 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Corient Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 30,197 | 30,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 30,891 | 30,891 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 157,578 | 157,578 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 19,310 | 19,296 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 22,900 | 22,292 | -608 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 21,896 | 20,905 | -991 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 62,134 | 60,820 | -1,314 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 2,092 | 0 | -2,092 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 89,631 | 86,920 | -2,711 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 1,144,396 | 1,140,592 | -3,804 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 11,296 | 7,396 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| Aldebaran Capital, LLC | 523,553 | 515,128 | -8,425 | 0.54 | 0.54 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 18,007 | 0 | -18,007 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 505,600 | 485,700 | -19,900 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,175,061 | 2,153,600 | -21,461 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 101,696 | 77,887 | -23,809 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,600 | 0 | -33,600 | 0.00 | 0.00 | -0.00 | sell |
| Peapod Lane Capital LLC | 489,370 | 452,682 | -36,688 | 0.60 | 0.48 | -0.12 | sell |
| TWO SIGMA INVESTMENTS, LP | 353,227 | 291,455 | -61,772 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 126,004 | 16,210 | -109,794 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 3,308,677 | 3,188,116 | -120,561 | 0.06 | 0.06 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129,914 | 0 | -129,914 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 155,389 | 23,995 | -131,394 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 267,636 | 0 | -267,636 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 949,726 | 647,629 | -302,097 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 3,301,942 | 0 | -3,301,942 | 0.28 | 0.00 | -0.28 | sell |