| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PFM Health Sciences, LP | 228,410 | 1,295,104 | +1,066,694 | 0.06 | 0.38 | +0.32 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,479,867 | 2,347,414 | +867,547 | 0.06 | 0.09 | +0.04 | buy |
| Tri Locum Partners LP | 158,413 | 821,384 | +662,971 | 0.37 | 1.62 | +1.25 | buy |
| Octagon Capital Advisors LP | 470,000 | 904,000 | +434,000 | 0.41 | 0.98 | +0.57 | buy |
| Woodline Partners LP | 733,735 | 1,090,740 | +357,005 | 0.05 | 0.08 | +0.02 | buy |
| Euclidean Capital LLC | 2,545,242 | 2,627,643 | +82,401 | 4.09 | 3.52 | -0.57 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 62,530 | 44,832 | +17,698 | 0.00 | 0.00 | 0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 86,401 | 74,525 | +11,876 | 0.01 | 0.00 | 0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 21,296 | 29,296 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 163,962 | 169,699 | +5,737 | 0.01 | 0.01 | +0.00 | buy |
| Belvedere Trading LLC | 24,411 | 29,294 | +4,883 | 0.05 | 0.02 | -0.03 | buy |
| China Universal Asset Management Co., Ltd. | 600 | 1,251 | +651 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 18,184 | 16,534 | -1,650 | 0.07 | 0.06 | -0.01 | sell |
| PDT Partners, LLC | 49,713 | 41,988 | -7,725 | 0.04 | 0.03 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 332,250 | 303,824 | -28,426 | 0.35 | 0.36 | +0.02 | sell |
| Avoro Capital Advisors LLC | 3,060,000 | 3,000,000 | -60,000 | 0.26 | 0.29 | +0.03 | sell |
| RTW INVESTMENTS, LP | 3,029,551 | 2,375,785 | -653,766 | 0.36 | 0.31 | -0.05 | sell |