| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ArrowMark Colorado Holdings LLC | 2,804,782 | 3,647,291 | +842,509 | 0.05 | 0.07 | +0.02 | buy |
| PFM Health Sciences, LP | 1,275,462 | 2,011,040 | +735,578 | 0.11 | 0.17 | +0.06 | buy |
| Sio Capital Management, LLC | 2,708,408 | 3,214,239 | +505,831 | 1.65 | 2.15 | +0.49 | buy |
| BML Capital Management, LLC | 1,309,397 | 1,688,772 | +379,375 | 1.55 | 1.48 | -0.07 | buy |
| TWO SIGMA ADVISERS, LP | 493,500 | 751,200 | +257,700 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 258,484 | 399,548 | +141,064 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 388,308 | 483,055 | +94,747 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 84,903 | 178,866 | +93,963 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 260,028 | 353,837 | +93,809 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 89,631 | +89,631 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 351,243 | 438,252 | +87,009 | 0.53 | 0.60 | +0.07 | buy |
| Acuitas Investments, LLC | 353,749 | 440,687 | +86,938 | 0.31 | 0.29 | -0.01 | buy |
| EVOKE WEALTH, LLC | 63,233 | 133,122 | +69,889 | 0.15 | 0.01 | -0.14 | buy |
| ADAR1 Capital Management, LLC | 50,000 | 101,008 | +51,008 | 0.02 | 0.03 | +0.01 | buy |
| MARSHALL WACE, LLP | 12,900 | 61,691 | +48,791 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 28,146 | +28,146 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 26,182 | +26,182 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 43,246 | 69,229 | +25,983 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 165,400 | 188,051 | +22,651 | 0.07 | 0.08 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,019,628 | 1,040,477 | +20,849 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 427,724 | 432,762 | +5,038 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 3,883 | 8,244 | +4,361 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 12,850 | 15,983 | +3,133 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 439,139 | 441,024 | +1,885 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 12,500 | 13,273 | +773 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 65 | 105 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 6,475,291 | 6,475,291 | 0 | 0.21 | 0.18 | -0.03 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,900 | 139,900 | 0 | 0.01 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 253,361 | 253,361 | 0 | 0.02 | 0.02 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 11,533 | 11,533 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 322,024 | 322,024 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Marquette Asset Management, LLC | 64,009 | 64,009 | 0 | 0.02 | 0.02 | -0.00 | hold |
| PERSONAL CFO SOLUTIONS, LLC | 550,342 | 550,342 | 0 | 0.14 | 0.11 | -0.02 | hold |
| Walleye Capital LLC | 145,737 | 145,737 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 0.53 | 0.43 | -0.10 | hold |
| Catalyst Funds Management Pty Ltd | 2,100 | 2,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corient Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nordwand Advisors, LLC | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 126,004 | 126,004 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,600 | 33,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 2,078,866 | 2,078,866 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE STREET CORP | 145,078 | 145,078 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 25,030 | 24,880 | -150 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 230 | 0 | -230 | 0.00 | 0.00 | 0.00 | sell |
| Capital Advisors, Ltd. LLC | 322 | 0 | -322 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 341 | 0 | -341 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 515,629 | 514,915 | -714 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,282,090 | 2,280,803 | -1,287 | 0.00 | 0.00 | -0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 2,345,361 | 2,343,731 | -1,630 | 0.02 | 0.02 | -0.00 | sell |
| MACQUARIE GROUP LTD | 2,077 | 0 | -2,077 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 3,592 | 1,005 | -2,587 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 77,743 | 73,352 | -4,391 | 0.01 | 0.01 | -0.00 | sell |
| HSBC HOLDINGS PLC | 43,713 | 39,080 | -4,633 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 4,711 | 0 | -4,711 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 51,124 | 43,293 | -7,831 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 21,459 | 12,738 | -8,721 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 49,794 | 39,522 | -10,272 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,873 | 0 | -11,873 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 12,014 | 0 | -12,014 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,896 | 2,187 | -12,709 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 14,545 | 0 | -14,545 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 15,130 | 0 | -15,130 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 30,716 | 11,711 | -19,005 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,151 | 0 | -21,151 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 23,035 | 0 | -23,035 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 25,022 | 0 | -25,022 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 62,634 | 32,190 | -30,444 | 0.02 | 0.01 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 31,749 | 0 | -31,749 | 0.00 | 0.00 | -0.00 | sell |
| Paloma Partners Management Co | 35,069 | 0 | -35,069 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 71,701 | 26,257 | -45,444 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 50,241 | 0 | -50,241 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 69,867 | 8,648 | -61,219 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 62,048 | 0 | -62,048 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 129,400 | 66,900 | -62,500 | 0.00 | 0.00 | -0.00 | sell |
| FISHMAN JAY A LTD/MI | 70,000 | 0 | -70,000 | 0.01 | 0.00 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 779,025 | 705,593 | -73,432 | 0.01 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 76,963 | 0 | -76,963 | 0.01 | 0.00 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,617 | 0 | -86,617 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 134,700 | 37,100 | -97,600 | 0.02 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 118,917 | 0 | -118,917 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 147,542 | 24,160 | -123,382 | 0.02 | 0.00 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,592 | 0 | -178,592 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 200,545 | 0 | -200,545 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 323,710 | 87,150 | -236,560 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 808,744 | 510,004 | -298,740 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 340,386 | 0 | -340,386 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 358,400 | 0 | -358,400 | 0.52 | 0.00 | -0.52 | sell |
| MILLENNIUM MANAGEMENT LLC | 758,740 | 363,969 | -394,771 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 464,952 | 30,248 | -434,704 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 475,000 | 0 | -475,000 | 0.18 | 0.00 | -0.18 | sell |
| CITADEL ADVISORS LLC | 1,716,474 | 1,055,696 | -660,778 | 0.00 | 0.00 | -0.00 | sell |