| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ArrowMark Colorado Holdings LLC | 270,426 | 2,714,143 | +2,443,717 | 0.02 | 0.09 | +0.07 | buy |
| Woodline Partners LP | 1,090,740 | 1,791,553 | +700,813 | 0.08 | 0.06 | -0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 303,824 | 685,985 | +382,161 | 0.36 | 0.92 | +0.55 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 350,342 | 550,342 | +200,000 | 0.43 | 0.30 | -0.13 | buy |
| PFM Health Sciences, LP | 1,295,104 | 1,473,013 | +177,909 | 0.37 | 0.27 | -0.10 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,000 | 194,900 | +99,900 | 0.01 | 0.01 | 0.00 | buy |
| DENALI ADVISORS LLC | 30,500 | 33,900 | +3,400 | 0.07 | 0.03 | -0.03 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 2,347,414 | 2,345,361 | -2,053 | 0.03 | 0.02 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 6,563,077 | 6,475,291 | -87,786 | 0.86 | 0.40 | -0.46 | sell |