| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 6,475,291 | 6,475,291 | 0 | 0.18 | 0.20 | +0.03 | hold |
| Sio Capital Management, LLC | 3,214,239 | 3,572,167 | +357,928 | 2.15 | 1.52 | -0.63 | buy |
| ArrowMark Colorado Holdings LLC | 3,647,291 | 3,508,451 | -138,840 | 0.07 | 0.07 | +0.00 | sell |
| BML Capital Management, LLC | 1,688,772 | 3,466,684 | +1,777,912 | 1.48 | 3.25 | +1.77 | buy |
| Euclidean Capital LLC | 2,627,643 | 2,627,643 | 0 | 0.43 | 0.54 | +0.11 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 2,343,731 | 2,343,731 | 0 | 0.02 | 0.02 | +0.00 | hold |
| VANGUARD GROUP INC | 2,280,803 | 2,143,102 | -137,701 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 2,011,040 | 2,079,245 | +68,205 | 0.17 | 0.24 | +0.07 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,078,866 | 2,078,866 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BlackRock, Inc. | 1,144,797 | 1,146,484 | +1,687 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,040,477 | 1,024,288 | -16,189 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 751,200 | 714,600 | -36,600 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 705,593 | 539,893 | -165,700 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 535,805 | +535,805 | 0.00 | 0.65 | +0.65 | buy |
| CITIGROUP INC | 514,915 | 514,911 | -4 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 483,055 | 506,986 | +23,931 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 438,252 | 502,190 | +63,938 | 0.60 | 0.72 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 432,762 | 421,710 | -11,052 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 399,548 | 399,548 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 441,024 | 370,920 | -70,104 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 322,024 | 322,024 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 363,969 | 318,020 | -45,949 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 178,866 | 275,464 | +96,598 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 253,361 | 245,561 | -7,800 | 0.02 | 0.02 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 139,900 | 202,100 | +62,200 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 145,078 | 157,578 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 188,051 | 156,451 | -31,600 | 0.08 | 0.06 | -0.02 | sell |
| Assenagon Asset Management S.A. | 353,837 | 153,701 | -200,136 | 0.00 | 0.00 | -0.00 | sell |
| EVOKE WEALTH, LLC | 133,122 | 133,122 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Walleye Capital LLC | 145,737 | 127,626 | -18,111 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 126,004 | 126,004 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GOLDMAN SACHS GROUP INC | 510,004 | 121,245 | -388,759 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,055,696 | 107,888 | -947,808 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 87,150 | 107,340 | +20,190 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 101,008 | 101,008 | 0 | 0.03 | 0.03 | +0.01 | hold |
| PANAGORA ASSET MANAGEMENT INC | 89,631 | 89,631 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 43,293 | 73,015 | +29,722 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 69,229 | 69,113 | -116 | 0.00 | 0.00 | +0.00 | sell |
| Marquette Asset Management, LLC | 64,009 | 64,009 | 0 | 0.02 | 0.02 | +0.00 | hold |
| HSBC HOLDINGS PLC | 39,080 | 39,080 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 66,900 | 35,200 | -31,700 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 0 | 35,000 | +35,000 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,600 | 33,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 32,190 | 32,603 | +413 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 30,248 | 30,197 | -51 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 37,100 | 28,700 | -8,400 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 24,880 | 24,880 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 39,522 | 22,807 | -16,715 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 11,711 | 16,935 | +5,224 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 15,983 | 14,983 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Independent Advisor Alliance | 13,273 | 12,514 | -759 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 61,691 | 11,014 | -50,677 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 24,160 | 10,877 | -13,283 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 12,738 | 4,938 | -7,800 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 8,244 | 4,034 | -4,210 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 8,648 | 2,595 | -6,053 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,187 | 1,525 | -662 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,005 | 1,005 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 763 | +763 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 105 | 105 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 11,533 | 0 | -11,533 | 0.01 | 0.00 | -0.01 | sell |
| Amundi | 26,182 | 0 | -26,182 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 73,352 | 0 | -73,352 | 0.01 | 0.00 | -0.01 | sell |
| Acuitas Investments, LLC | 440,687 | 0 | -440,687 | 0.29 | 0.00 | -0.29 | sell |
| Virtu Financial LLC | 28,146 | 0 | -28,146 | 0.00 | 0.00 | -0.00 | sell |
| PERSONAL CFO SOLUTIONS, LLC | 550,342 | 0 | -550,342 | 0.11 | 0.00 | -0.11 | sell |
| Qube Research & Technologies Ltd | 26,257 | 0 | -26,257 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| Nordwand Advisors, LLC | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |