| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Anson Funds Management LP | 4,297,699 | 3,750,450 | -547,249 | 1.22 | 0.46 | -0.76 | sell |
| VANGUARD GROUP INC | 1,643,757 | 1,653,432 | +9,675 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,067,711 | 926,929 | -140,782 | 0.70 | 0.44 | -0.27 | sell |
| Alphabet Inc. | 889,979 | 889,979 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Murchinson Ltd. | 862,700 | 873,910 | +11,210 | 0.22 | 0.17 | -0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 547,465 | 854,460 | +306,995 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 343,856 | 762,598 | +418,742 | 0.00 | 0.00 | +0.00 | buy |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | 607,613 | -405,825 | 0.18 | 0.10 | -0.08 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 412,707 | 469,441 | +56,734 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 468,902 | 468,902 | 0 | 7.62 | 0.06 | -7.56 | hold |
| AWM Investment Company, Inc. | 333,400 | 333,400 | 0 | 0.06 | 0.08 | +0.01 | hold |
| Shay Capital LLC | 0 | 306,967 | +306,967 | 0.00 | 0.15 | +0.15 | buy |
| Man Group plc | 0 | 214,026 | +214,026 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,800 | 184,800 | +50,000 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 148,857 | 147,872 | -985 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 130,511 | 130,511 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DAFNA Capital Management LLC | 125,000 | 125,000 | 0 | 0.04 | 0.05 | +0.00 | hold |
| NORTHERN TRUST CORP | 88,881 | 114,559 | +25,678 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 79,500 | +79,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 122,802 | 79,401 | -43,401 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 0 | 60,900 | +60,900 | 0.00 | 0.00 | +0.00 | buy |
| DLK Investment Management, LLC | 31,355 | 31,355 | 0 | 0.02 | 0.02 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,565 | 28,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACKENZIE FINANCIAL CORP | 21,462 | 28,442 | +6,980 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 28,319 | +28,319 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 28,200 | 25,400 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 18,180 | +18,180 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 65,966 | 15,013 | -50,953 | 0.02 | 0.00 | -0.02 | sell |
| Three Seasons Wealth, LLC | 15,000 | 15,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 10,003 | 10,003 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 6,400 | 6,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 189 | 2,389 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 1,248 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 650 | +650 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Raleigh Capital Management Inc. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 458 | 458 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 151 | 151 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CoreCap Advisors, LLC | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFS Partners, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 730 | 30 | -700 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOURGEON CAPITAL MANAGEMENT LLC | 15,100 | 0 | -15,100 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,301 | 0 | -10,301 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 402,963 | 0 | -402,963 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 4,590 | 0 | -4,590 | 0.00 | 0.00 | -0.00 | sell |