| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Three Seasons Wealth, LLC | 15,000 | 30,000 | +15,000 | 0.01 | 0.02 | +0.01 | buy |
| PFG Investments, LLC | 0 | 13,979 | +13,979 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 2,880 | +2,880 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 921 | +921 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,889 | 3,139 | +250 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 184,800 | 184,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Novo Holdings A/S | 468,902 | 468,902 | 0 | 0.03 | 0.03 | -0.00 | hold |
| DAFNA Capital Management LLC | 125,000 | 125,000 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Anson Funds Management LP | 3,750,450 | 3,750,450 | 0 | 0.70 | 0.68 | -0.02 | hold |
| AWM Investment Company, Inc. | 333,400 | 333,400 | 0 | 0.06 | 0.05 | -0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 889,979 | 889,979 | 0 | 0.06 | 0.06 | +0.01 | hold |
| Russell Investments Group, Ltd. | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Shay Capital LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CoreCap Advisors, LLC | 192 | 192 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DLK Investment Management, LLC | 31,355 | 31,355 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 10,003 | 10,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 151 | 151 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CULLEN/FROST BANKERS, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,565 | 28,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,071,860 | 1,071,860 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 130,511 | 130,511 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 458 | 0 | -458 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 600 | 0 | -600 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 112,303 | 111,497 | -806 | 0.00 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 32,729 | 31,903 | -826 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 975,952 | 974,653 | -1,299 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,770,525 | 1,763,620 | -6,905 | 0.00 | 0.00 | -0.00 | sell |
| Texas Yale Capital Corp. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 492,187 | 481,187 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 73,469 | 38,481 | -34,988 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 98,518 | 32,172 | -66,346 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 67,728 | 0 | -67,728 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 535,336 | 402,885 | -132,451 | 0.07 | 0.05 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 918,929 | 743,459 | -175,470 | 0.24 | 0.17 | -0.07 | sell |
| CITADEL ADVISORS LLC | 312,034 | 81,425 | -230,609 | 0.00 | 0.00 | -0.00 | sell |
| Murchinson Ltd. | 873,910 | 0 | -873,910 | 0.24 | 0.00 | -0.24 | sell |