| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Anson Funds Management LP | 4,159,572 | 4,297,699 | +138,127 | 1.47 | 1.22 | -0.25 | buy |
| VANGUARD GROUP INC | 1,557,596 | 1,643,757 | +86,161 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 272,024 | 343,856 | +71,832 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 119,694 | 148,857 | +29,163 | 0.00 | 0.00 | +0.00 | buy |
| Three Seasons Wealth, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,301 | +10,301 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 58,368 | 65,966 | +7,598 | 0.01 | 0.02 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 17,198 | 21,462 | +4,264 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 547,165 | 547,465 | +300 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 189 | +189 | 0.00 | 0.00 | +0.00 | buy |
| BOURGEON CAPITAL MANAGEMENT LLC | 15,100 | 15,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134,800 | 134,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 458 | 458 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 28,200 | 28,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 412,707 | 412,707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 468,902 | 468,902 | 0 | 0.04 | 7.62 | +7.58 | hold |
| DAFNA Capital Management LLC | 125,000 | 125,000 | 0 | 0.05 | 0.04 | -0.00 | hold |
| AWM Investment Company, Inc. | 333,400 | 333,400 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Allworth Financial LP | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 889,979 | 889,979 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Russell Investments Group, Ltd. | 6,400 | 6,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Murchinson Ltd. | 862,700 | 862,700 | 0 | 0.16 | 0.22 | +0.06 | hold |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | 1,013,438 | 0 | 0.19 | 0.18 | -0.01 | hold |
| Federation des caisses Desjardins du Quebec | 730 | 730 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 151 | 151 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 88,881 | 88,881 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,565 | 28,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 130,511 | 130,511 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Heritage Wealth Advisors | 187 | 0 | -187 | 0.00 | 0.00 | -0.00 | sell |
| PFS Partners, LLC | 250 | 50 | -200 | 0.00 | 0.00 | -0.00 | sell |
| Beaird Harris Wealth Management, LLC | 202 | 0 | -202 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 11,753 | 10,003 | -1,750 | 0.00 | 0.00 | -0.00 | sell |
| CULLEN/FROST BANKERS, INC. | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 129,497 | 122,802 | -6,695 | 0.00 | 0.00 | -0.00 | sell |
| ERn Financial, LLC | 15,766 | 0 | -15,766 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 17,023 | 0 | -17,023 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 18,627 | 0 | -18,627 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 34,190 | 4,590 | -29,600 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 57,373 | 0 | -57,373 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 463,641 | 402,963 | -60,678 | 0.00 | 0.00 | -0.00 | sell |