| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Anson Funds Management LP | 3,750,450 | 3,839,886 | +89,436 | 0.68 | 0.49 | -0.20 | buy |
| VANGUARD GROUP INC | 1,763,620 | 1,763,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 974,653 | 1,105,591 | +130,938 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,071,860 | 1,039,922 | -31,938 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 889,979 | 889,979 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Murchinson Ltd. | 0 | 873,910 | +873,910 | 0.00 | 0.40 | +0.40 | buy |
| ADAR1 Capital Management, LLC | 743,459 | 801,277 | +57,818 | 0.17 | 0.17 | +0.00 | buy |
| BlackRock, Inc. | 484,820 | 485,352 | +532 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 481,187 | 481,128 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 402,885 | 305,255 | -97,630 | 0.05 | 0.04 | -0.01 | sell |
| MACKENZIE FINANCIAL CORP | 31,903 | 187,559 | +155,656 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 31,903 | 187,559 | +155,656 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 184,800 | 184,800 | 0 | 0.01 | 0.00 | -0.00 | hold |
| CITADEL ADVISORS LLC | 81,425 | 172,872 | +91,447 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 130,511 | 148,911 | +18,400 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 125,000 | 125,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| NORTHERN TRUST CORP | 111,497 | 86,447 | -25,050 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 0 | 61,624 | +61,624 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 55,051 | +55,051 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 49,200 | +49,200 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 46,046 | +46,046 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 30,138 | +30,138 | 0.00 | 0.00 | +0.00 | buy |
| Three Seasons Wealth, LLC | 30,000 | 30,000 | 0 | 0.02 | 0.02 | -0.01 | hold |
| DLK Investment Management, LLC | 31,355 | 28,955 | -2,400 | 0.02 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,565 | 28,565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFG Investments, LLC | 13,979 | 24,534 | +10,555 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 14,692 | +14,692 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 10,003 | 10,003 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Texas Yale Capital Corp. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 151 | 5,151 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 921 | 5,110 | +4,189 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,139 | 4,289 | +1,150 | 0.00 | 0.00 | +0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CoreCap Advisors, LLC | 192 | 50 | -142 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 32,172 | 0 | -32,172 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 2,880 | 0 | -2,880 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 468,902 | 0 | -468,902 | 0.03 | 0.00 | -0.03 | sell |
| AWM Investment Company, Inc. | 333,400 | 0 | -333,400 | 0.05 | 0.00 | -0.05 | sell |
| Man Group plc | 38,481 | 0 | -38,481 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 6,400 | 0 | -6,400 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 25,000 | 0 | -25,000 | 0.01 | 0.00 | -0.01 | sell |