| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 22,909,753 | 27,525,640 | +4,615,887 | 1.49 | 1.56 | +0.08 | buy |
| BAILLIE GIFFORD & CO | 24,044,796 | 23,180,089 | -864,707 | 0.11 | 0.08 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.06 | 0.05 | -0.02 | hold |
| Capital World Investors | 8,351,293 | 8,351,293 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.48 | 0.35 | -0.13 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.26 | 0.21 | -0.05 | hold |
| Founders Fund VII Management, LLC | 3,773,530 | 3,773,530 | 0 | 89.83 | 88.05 | -1.78 | hold |
| FEDERATED HERMES, INC. | 3,117,680 | 2,815,459 | -302,221 | 0.04 | 0.03 | -0.01 | sell |
| Casdin Capital, LLC | 2,360,129 | 2,360,129 | 0 | 1.33 | 0.80 | -0.53 | hold |
| LAZARD ASSET MANAGEMENT LLC | 3,412,005 | 2,020,012 | -1,391,993 | 0.02 | 0.01 | -0.01 | sell |
| Prosight Management, LP | 1,700,000 | 1,790,000 | +90,000 | 3.90 | 2.26 | -1.64 | buy |
| TWO SIGMA ADVISERS, LP | 993,300 | 1,757,600 | +764,300 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,459,503 | 1,489,603 | +30,100 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,069,238 | 1,480,915 | +411,677 | 0.01 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,255,219 | 1,268,018 | +12,799 | 0.01 | 0.00 | -0.00 | buy |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.40 | 0.35 | -0.05 | hold |
| NORGES BANK | 922,214 | 922,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Man Group plc | 0 | 771,934 | +771,934 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 578,306 | 764,833 | +186,527 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 887,283 | 541,783 | -345,500 | 1.46 | 0.65 | -0.82 | sell |
| ExodusPoint Capital Management, LP | 133,654 | 496,012 | +362,358 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 30,633 | 453,235 | +422,602 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 460,900 | 450,255 | -10,645 | 0.00 | 0.00 | -0.00 | sell |
| Founders Fund Growth Management, LLC | 407,017 | 407,017 | 0 | 2.81 | 2.94 | +0.13 | hold |
| ROYAL BANK OF CANADA | 388,119 | 392,357 | +4,238 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 376,890 | 390,139 | +13,249 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 409,259 | 370,765 | -38,494 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 289,886 | 289,836 | -50 | 0.00 | 0.00 | -0.00 | sell |
| Belmont Capital, LLC | 510,000 | 260,000 | -250,000 | 1.24 | 0.32 | -0.92 | sell |
| TD Waterhouse Canada Inc. | 258,130 | 258,322 | +192 | 0.01 | 0.01 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 256,144 | 257,366 | +1,222 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 250,248 | 250,248 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PDT Partners, LLC | 247,378 | 247,478 | +100 | 0.16 | 0.11 | -0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 335,992 | 222,058 | -113,934 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 247,597 | 221,913 | -25,684 | 0.05 | 0.03 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 601,241 | 206,427 | -394,814 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 7,685 | 183,885 | +176,200 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 94,567 | 178,557 | +83,990 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 120,657 | 172,358 | +51,701 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 171,516 | 157,083 | -14,433 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 91,367 | 150,567 | +59,200 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 140,000 | 140,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 119,399 | 119,399 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Asset Management Partners Inc. | 117,830 | 117,830 | 0 | 0.02 | 0.01 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 117,555 | 117,324 | -231 | 0.00 | 0.00 | -0.00 | sell |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.27 | 0.22 | -0.06 | hold |
| TrueMark Investments, LLC | 96,853 | 109,957 | +13,104 | 0.55 | 0.46 | -0.09 | buy |
| STIFEL FINANCIAL CORP | 110,145 | 109,277 | -868 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 102,158 | 104,847 | +2,689 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 101,975 | +101,975 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 10,490 | 100,280 | +89,790 | 0.01 | 0.08 | +0.07 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 100,145 | +100,145 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 243,440 | 98,885 | -144,555 | 0.00 | 0.00 | -0.00 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 99,986 | 93,288 | -6,698 | 0.09 | 0.06 | -0.04 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 90,734 | +90,734 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 90,324 | 89,900 | -424 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 86,624 | 86,624 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 350,670 | 86,120 | -264,550 | 0.17 | 0.03 | -0.14 | sell |
| DUALITY ADVISERS, LP | 111,041 | 68,099 | -42,942 | 0.07 | 0.03 | -0.04 | sell |
| LPL Financial LLC | 0 | 65,743 | +65,743 | 0.00 | 0.00 | +0.00 | buy |
| FIL Ltd | 1,875,872 | 65,080 | -1,810,792 | 0.01 | 0.00 | -0.01 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 62,759 | 62,759 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Handelsbanken Fonder AB | 45,400 | 60,200 | +14,800 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 14,853 | 58,510 | +43,657 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Advisors LLC | 57,526 | 57,526 | 0 | 0.04 | 0.05 | +0.00 | hold |
| BRANDYWINE MANAGERS, LLC | 56,976 | 56,976 | 0 | 0.36 | 0.25 | -0.10 | hold |
| China Universal Asset Management Co., Ltd. | 33,566 | 56,306 | +22,740 | 0.04 | 0.03 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 56,860 | 53,474 | -3,386 | 0.01 | 0.01 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 52,800 | +52,800 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 12,521 | 50,971 | +38,450 | 0.04 | 0.21 | +0.17 | buy |
| NORTHERN TRUST CORP | 56,477 | 47,691 | -8,786 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 75,157 | 47,551 | -27,606 | 0.01 | 0.01 | -0.01 | sell |
| Ratan Capital Management LP | 0 | 47,265 | +47,265 | 0.00 | 0.11 | +0.11 | buy |
| Squarepoint Ops LLC | 52,007 | 46,776 | -5,231 | 0.00 | 0.00 | -0.00 | sell |
| Stratos Wealth Advisors, LLC | 43,500 | 45,500 | +2,000 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 31,443 | 44,127 | +12,684 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 40,971 | 44,074 | +3,103 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 20,557 | 38,557 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 38,855 | 37,154 | -1,701 | 0.00 | 0.00 | -0.00 | sell |
| PIER 88 INVESTMENT PARTNERS LLC | 0 | 34,980 | +34,980 | 0.00 | 0.04 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 111,188 | 34,204 | -76,984 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 21,674 | 32,775 | +11,101 | 0.00 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 31,123 | +31,123 | 0.00 | 0.03 | +0.03 | buy |
| Cambridge Investment Research Advisors, Inc. | 31,626 | 30,805 | -821 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 27,827 | 28,347 | +520 | 0.11 | 0.09 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 30,316 | 28,116 | -2,200 | 0.00 | 0.00 | -0.00 | sell |
| GTS SECURITIES LLC | 31,748 | 27,440 | -4,308 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 0 | 22,877 | +22,877 | 0.00 | 0.00 | +0.00 | buy |
| Lantern Wealth Advisors, LLC | 22,550 | 22,550 | 0 | 0.10 | 0.07 | -0.03 | hold |
| Parkwood LLC | 0 | 21,533 | +21,533 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 18,540 | 20,518 | +1,978 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 18,700 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 17,417 | 17,779 | +362 | 0.06 | 0.05 | -0.01 | buy |
| Pathstone Holdings, LLC | 16,714 | 17,038 | +324 | 0.00 | 0.00 | -0.00 | buy |
| PFG Investments, LLC | 0 | 16,600 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 16,894 | 15,812 | -1,082 | 0.06 | 0.04 | -0.02 | sell |
| Vontobel Holding Ltd. | 0 | 15,311 | +15,311 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 14,375 | 15,225 | +850 | 0.00 | 0.00 | -0.00 | buy |