| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,500,000 | 15,671,063 | +11,171,063 | 0.00 | 0.01 | +0.01 | buy |
| Capital World Investors | 7,933,613 | 13,361,096 | +5,427,483 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,975,348 | 5,082,183 | +3,106,835 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 597,251 | 1,814,474 | +1,217,223 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,486,893 | 2,894,029 | +407,136 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 937,385 | 1,291,016 | +353,631 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 324,802 | 627,141 | +302,339 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 113,773 | 350,887 | +237,114 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 132,014 | 215,774 | +83,760 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 13,521 | 81,083 | +67,562 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 83,519 | 141,325 | +57,806 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 55,645 | +55,645 | 0.00 | 0.03 | +0.03 | buy |
| Jain Global LLC | 0 | 54,918 | +54,918 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 47,480 | +47,480 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 2,608,400 | 2,644,800 | +36,400 | 0.02 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 916,237 | 947,751 | +31,514 | 0.01 | 0.00 | -0.00 | buy |
| GEM Asset Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.04 | +0.04 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 28,241 | +28,241 | 0.00 | 0.03 | +0.03 | buy |
| Wealthquest Corp | 0 | 24,984 | +24,984 | 0.00 | 0.11 | +0.11 | buy |
| Virtu Financial LLC | 0 | 23,369 | +23,369 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 168,682 | 187,822 | +19,140 | 0.21 | 0.19 | -0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,582,816 | 2,600,000 | +17,184 | 0.50 | 0.32 | -0.18 | buy |
| SIH Partners, LLLP | 0 | 17,163 | +17,163 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 15,577 | +15,577 | 0.00 | 0.00 | +0.00 | buy |
| AssuredPartners Investment Advisors, LLC | 0 | 15,356 | +15,356 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 11,578 | 25,622 | +14,044 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 13,043 | +13,043 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,253 | 24,146 | +12,893 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Advisors, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 11 | 10,900 | +10,889 | 0.00 | 0.00 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 236,900 | 243,790 | +6,890 | 0.14 | 0.10 | -0.03 | buy |
| CIBC WORLD MARKET INC. | 16,865 | 23,565 | +6,700 | 0.00 | 0.00 | +0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 73,650 | 78,800 | +5,150 | 0.01 | 0.01 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 19,501 | 23,979 | +4,478 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 4,205 | +4,205 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 38,351 | 41,895 | +3,544 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 18,428 | 21,960 | +3,532 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 6,202 | 7,563 | +1,361 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,956 | 3,004 | +1,048 | 0.00 | 0.00 | +0.00 | buy |
| SCOTIA CAPITAL INC. | 15,124 | 16,071 | +947 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 547,533 | 548,133 | +600 | 0.36 | 0.30 | -0.05 | buy |
| SBI Securities Co., Ltd. | 2,391 | 2,920 | +529 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 13,806 | 14,254 | +448 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 3,096 | 3,319 | +223 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 9,843 | 9,929 | +86 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.25 | 0.22 | -0.03 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.03 | 0.03 | -0.01 | hold |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 39,668 | 39,668 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 135 | 135 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRANDYWINE MANAGERS, LLC | 28,488 | 28,488 | 0 | 0.09 | 0.08 | -0.01 | hold |
| PRINCIPAL SECURITIES, INC. | 1,433 | 1,433 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 27,525,640 | 27,525,640 | 0 | 0.86 | 0.68 | -0.18 | hold |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.20 | 0.19 | -0.01 | hold |
| Parkside Financial Bank & Trust | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 1,151 | 1,151 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.11 | 0.08 | -0.03 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.16 | 0.15 | -0.01 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 340,267 | 340,267 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clarkston Capital Partners, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 64,304 | 64,304 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Cerity Partners LLC | 53,057 | 53,057 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MISSION WEALTH MANAGEMENT, LP | 10,651 | 10,651 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 12,600 | 12,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pacifica Partners Inc. | 7,619 | 7,619 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Resolute Advisors LLC | 61,576 | 61,576 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Continuum Advisory, LLC | 93 | 93 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Guardian Partners Inc. | 1,786,414 | 1,786,414 | 0 | 0.55 | 0.47 | -0.08 | hold |
| Integrity Financial Corp /WA | 12,050 | 12,050 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Farther Finance Advisors, LLC | 15,893 | 15,893 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AA Financial Advisors, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IMG Wealth Management, Inc. | 19,000 | 19,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Aviso Financial Inc. | 6,540 | 6,540 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DKM Wealth Management, Inc. | 10,000 | 10,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 610 | 610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CKW FINANCIAL GROUP | 50 | 0 | -50 | 0.00 | 0.00 | 0.00 | sell |
| Morton Brown Family Wealth, LLC | 75 | 0 | -75 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 15,400 | 15,300 | -100 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 116,887 | 116,664 | -223 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,726 | 4,432 | -294 | 0.00 | 0.00 | -0.00 | sell |
| CVA Family Office, LLC | 339 | 0 | -339 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 1,282 | 902 | -380 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 37,835 | 37,450 | -385 | 0.09 | 0.09 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 625 | 200 | -425 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 470 | 0 | -470 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 21,363 | 20,863 | -500 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 13,990 | 13,443 | -547 | 0.00 | 0.00 | -0.00 | sell |
| Physician Wealth Advisors, Inc. | 593 | 0 | -593 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 634 | 0 | -634 | 0.00 | 0.00 | -0.00 | sell |
| Eagle Bay Advisors LLC | 710 | 0 | -710 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 21,499 | 20,344 | -1,155 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 14,000 | 12,500 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 62,629 | 59,771 | -2,858 | 0.02 | 0.01 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 51,447 | 47,934 | -3,513 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 14,540 | 10,966 | -3,574 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 71,514 | 67,664 | -3,850 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 18,104 | 13,238 | -4,866 | 0.04 | 0.04 | -0.00 | sell |