| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 27,525,640 | 27,525,640 | 0 | 1.56 | 1.04 | -0.52 | hold |
| BAILLIE GIFFORD & CO | 23,180,089 | 21,911,014 | -1,269,075 | 0.08 | 0.05 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Capital World Investors | 8,351,293 | 5,318,793 | -3,032,500 | 0.01 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 4,598,626 | +4,598,626 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.35 | 0.25 | -0.10 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.21 | 0.14 | -0.06 | hold |
| Founders Fund VII Management, LLC | 3,773,530 | 3,773,530 | 0 | 88.05 | 86.90 | -1.15 | hold |
| FEDERATED HERMES, INC. | 2,815,459 | 2,726,016 | -89,443 | 0.03 | 0.02 | -0.01 | sell |
| Prosight Management, LP | 1,790,000 | 2,352,633 | +562,633 | 2.26 | 2.08 | -0.17 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,480,915 | 2,061,356 | +580,441 | 0.02 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,757,600 | 1,764,800 | +7,200 | 0.02 | 0.01 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,489,603 | 1,728,603 | +239,000 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 764,833 | 1,473,210 | +708,377 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.35 | 0.18 | -0.17 | hold |
| LAZARD ASSET MANAGEMENT LLC | 2,020,012 | 1,092,169 | -927,843 | 0.01 | 0.00 | -0.01 | sell |
| NORGES BANK | 922,214 | 922,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MORGAN STANLEY | 390,139 | 552,130 | +161,991 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 541,783 | 545,533 | +3,750 | 0.65 | 0.44 | -0.20 | buy |
| Exome Asset Management LLC | 0 | 514,900 | +514,900 | 0.00 | 1.36 | +1.36 | buy |
| D. E. Shaw & Co., Inc. | 453,235 | 466,565 | +13,330 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 461,699 | +461,699 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,268,018 | 450,690 | -817,328 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 392,357 | 408,874 | +16,517 | 0.00 | 0.00 | -0.00 | buy |
| Founders Fund Growth Management, LLC | 407,017 | 407,017 | 0 | 2.94 | 3.68 | +0.74 | hold |
| JPMORGAN CHASE & CO | 370,765 | 334,264 | -36,501 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 450,255 | 318,550 | -131,705 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 257,366 | 314,866 | +57,500 | 0.00 | 0.00 | -0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 311,890 | +311,890 | 0.00 | 0.02 | +0.02 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 150,567 | 308,567 | +158,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 289,836 | 289,836 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Belmont Capital, LLC | 260,000 | 260,000 | 0 | 0.32 | 0.14 | -0.18 | hold |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 250,248 | 250,248 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,058 | 248,748 | +26,690 | 0.00 | 0.00 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 258,322 | 245,604 | -12,718 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 247,478 | 238,188 | -9,290 | 0.11 | 0.07 | -0.04 | sell |
| TUDOR INVESTMENT CORP ET AL | 90,734 | 236,649 | +145,915 | 0.01 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.14 | +0.14 | buy |
| DIMENSIONAL FUND ADVISORS LP | 178,557 | 179,882 | +1,325 | 0.00 | 0.00 | -0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 34,980 | 161,620 | +126,640 | 0.04 | 0.11 | +0.07 | buy |
| JANE STREET GROUP, LLC | 98,885 | 154,772 | +55,887 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 100,280 | 146,001 | +45,721 | 0.08 | 0.08 | +0.00 | buy |
| TORONTO DOMINION BANK | 140,000 | 140,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 120,900 | +120,900 | 0.00 | 0.03 | +0.03 | buy |
| FIL Ltd | 65,080 | 119,973 | +54,893 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 119,399 | 119,399 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polar Asset Management Partners Inc. | 117,830 | 117,830 | 0 | 0.01 | 0.01 | -0.01 | hold |
| AMERICAN CENTURY COMPANIES INC | 117,324 | 117,216 | -108 | 0.00 | 0.00 | -0.00 | sell |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.22 | 0.13 | -0.09 | hold |
| TrueMark Investments, LLC | 109,957 | 109,957 | 0 | 0.46 | 0.11 | -0.35 | hold |
| OSAIC HOLDINGS, INC. | 104,847 | 106,477 | +1,630 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 109,277 | 102,377 | -6,900 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 206,427 | 95,768 | -110,659 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 101,975 | 94,991 | -6,984 | 0.00 | 0.00 | -0.00 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 93,288 | 88,410 | -4,878 | 0.06 | 0.03 | -0.02 | sell |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 4,040 | 79,289 | +75,249 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 60,200 | 69,900 | +9,700 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 46,776 | 68,908 | +22,132 | 0.00 | 0.00 | -0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 0 | 63,000 | +63,000 | 0.00 | 0.01 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 62,759 | 62,759 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Resolute Advisors LLC | 57,526 | 57,526 | 0 | 0.05 | 0.04 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 50,971 | 50,971 | 0 | 0.21 | 0.16 | -0.05 | hold |
| Headlands Technologies LLC | 0 | 49,393 | +49,393 | 0.00 | 0.02 | +0.02 | buy |
| Stratos Wealth Advisors, LLC | 45,500 | 45,500 | 0 | 0.01 | 0.01 | -0.01 | hold |
| BANK OF MONTREAL /CAN/ | 44,127 | 41,659 | -2,468 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 47,691 | 40,382 | -7,309 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 0 | 39,668 | +39,668 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 183,885 | 39,095 | -144,790 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 53,474 | 37,185 | -16,289 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 58,510 | 34,794 | -23,716 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 56,306 | 34,546 | -21,760 | 0.03 | 0.01 | -0.02 | sell |
| XTX Topco Ltd | 0 | 33,590 | +33,590 | 0.00 | 0.01 | +0.01 | buy |
| Parkwood LLC | 21,533 | 32,357 | +10,824 | 0.01 | 0.01 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 30,761 | +30,761 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 29,112 | +29,112 | 0.00 | 0.01 | +0.01 | buy |
| BRANDYWINE MANAGERS, LLC | 56,976 | 28,488 | -28,488 | 0.25 | 0.09 | -0.17 | sell |
| EntryPoint Capital, LLC | 3,728 | 28,091 | +24,363 | 0.02 | 0.04 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 15,812 | 27,185 | +11,373 | 0.04 | 0.04 | +0.00 | buy |
| Green Alpha Advisors, LLC | 28,347 | 24,709 | -3,638 | 0.09 | 0.06 | -0.03 | sell |
| Cambridge Investment Research Advisors, Inc. | 30,805 | 24,168 | -6,637 | 0.00 | 0.00 | -0.00 | sell |
| Lantern Wealth Advisors, LLC | 22,550 | 23,300 | +750 | 0.07 | 0.05 | -0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 86,120 | 22,163 | -63,957 | 0.03 | 0.00 | -0.03 | sell |
| B. Riley Wealth Advisors, Inc. | 10,500 | 21,500 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 89,900 | 21,497 | -68,403 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 172,358 | 20,828 | -151,530 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 38,557 | 20,557 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 65,743 | 19,063 | -46,680 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 32,775 | 18,975 | -13,800 | 0.01 | 0.00 | -0.00 | sell |
| GTS SECURITIES LLC | 27,440 | 18,355 | -9,085 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKET INC. | 15,225 | 18,165 | +2,940 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 20,518 | 18,152 | -2,366 | 0.00 | 0.00 | -0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 17,779 | 17,779 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Pathstone Holdings, LLC | 17,038 | 16,810 | -228 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 28,116 | 15,680 | -12,436 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 16,600 | 15,100 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| SCOTIA CAPITAL INC. | 15,069 | 15,069 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 15,012 | 15,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEARLE & CO. | 13,900 | 15,000 | +1,100 | 0.02 | 0.01 | -0.01 | buy |