| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 27,525,640 | 27,525,640 | 0 | 0.68 | 0.92 | +0.24 | hold |
| Capital World Investors | 13,361,096 | 13,361,096 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BAILLIE GIFFORD & CO | 11,195,832 | 10,360,004 | -835,828 | 0.02 | 0.03 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,671,063 | 8,471,619 | -7,199,444 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 3,126,789 | 4,110,852 | +984,063 | 0.02 | 0.03 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.15 | 0.25 | +0.11 | hold |
| TWO SIGMA ADVISERS, LP | 2,644,800 | 4,070,300 | +1,425,500 | 0.01 | 0.03 | +0.02 | buy |
| BlackRock, Inc. | 3,576,208 | 3,680,794 | +104,586 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 5,082,183 | 3,447,925 | -1,634,258 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 869,709 | 3,397,589 | +2,527,880 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 4,180,768 | 3,344,568 | -836,200 | 0.22 | 0.29 | +0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,894,029 | 3,307,429 | +413,400 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,814,474 | 2,889,760 | +1,075,286 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,600,000 | 2,600,000 | 0 | 0.32 | 0.45 | +0.13 | hold |
| Guardian Partners Inc. | 1,786,414 | 1,786,414 | 0 | 0.47 | 0.68 | +0.21 | hold |
| MORGAN STANLEY | 1,291,016 | 996,927 | -294,089 | 0.00 | 0.00 | +0.00 | sell |
| Novo Holdings A/S | 1,126,915 | 652,529 | -474,386 | 0.19 | 0.16 | -0.03 | sell |
| NORGES BANK | 630,938 | 630,938 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 627,141 | 614,293 | -12,848 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 248,645 | 594,288 | +345,643 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 548,133 | 548,133 | 0 | 0.30 | 0.41 | +0.10 | hold |
| LAZARD ASSET MANAGEMENT LLC | 833,162 | 509,794 | -323,368 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 499,922 | +499,922 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 387,031 | 403,916 | +16,885 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 193,283 | 371,013 | +177,730 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 350,887 | 363,188 | +12,301 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 340,267 | 340,267 | 0 | 0.00 | 0.01 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 215,774 | 268,001 | +52,227 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 243,790 | 244,180 | +390 | 0.10 | 0.16 | +0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 266,895 | 238,539 | -28,356 | 0.05 | 0.06 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 224,365 | +224,365 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 86,483 | 218,725 | +132,242 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 23,369 | 206,710 | +183,341 | 0.00 | 0.04 | +0.03 | buy |
| Polar Asset Management Partners Inc. | 0 | 159,800 | +159,800 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 143,035 | +143,035 | 0.00 | 0.01 | +0.01 | buy |
| PEAK6 LLC | 168,605 | 136,614 | -31,991 | 0.01 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 204,253 | 135,441 | -68,812 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 80,771 | 131,090 | +50,319 | 0.01 | 0.01 | +0.01 | buy |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.08 | 0.12 | +0.03 | hold |
| AMERICAN CENTURY COMPANIES INC | 116,664 | 113,760 | -2,904 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 67,664 | 112,243 | +44,579 | 0.00 | 0.00 | +0.00 | buy |
| TrueMark Investments, LLC | 115,391 | 111,119 | -4,272 | 0.07 | 0.08 | +0.01 | sell |
| JANE STREET GROUP, LLC | 0 | 93,980 | +93,980 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 187,822 | 89,570 | -98,252 | 0.19 | 0.15 | -0.04 | sell |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 75,068 | 75,782 | +714 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 47,934 | 70,089 | +22,155 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 45,253 | 66,444 | +21,191 | 0.01 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 141,325 | 65,607 | -75,718 | 0.01 | 0.00 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 64,813 | +64,813 | 0.00 | 0.02 | +0.02 | buy |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 59,771 | 59,949 | +178 | 0.01 | 0.02 | +0.01 | buy |
| Resolute Advisors LLC | 61,576 | 57,526 | -4,050 | 0.04 | 0.05 | +0.01 | sell |
| Cerity Partners LLC | 53,057 | 53,057 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 947,751 | 53,000 | -894,751 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 51,074 | +51,074 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 0 | 49,225 | +49,225 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 47,480 | 47,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 41,895 | 43,028 | +1,133 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 38,347 | 41,003 | +2,656 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 39,668 | 39,668 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Headlands Technologies LLC | 0 | 37,795 | +37,795 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 24,146 | 37,112 | +12,966 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 36,427 | +36,427 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 81,083 | 34,912 | -46,171 | 0.00 | 0.00 | -0.00 | sell |
| XML Financial, LLC | 0 | 34,500 | +34,500 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 55,645 | 29,852 | -25,793 | 0.03 | 0.03 | +0.00 | sell |
| Green Alpha Advisors, LLC | 37,450 | 29,103 | -8,347 | 0.09 | 0.10 | +0.01 | sell |
| SCOTIA CAPITAL INC. | 16,071 | 29,024 | +12,953 | 0.00 | 0.00 | +0.00 | buy |
| BRANDYWINE MANAGERS, LLC | 28,488 | 28,488 | 0 | 0.08 | 0.10 | +0.02 | hold |
| RAYMOND JAMES FINANCIAL INC | 23,979 | 28,049 | +4,070 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 23,565 | 25,065 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 0 | 23,689 | +23,689 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 23,440 | 23,353 | -87 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 15,577 | 21,979 | +6,402 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 20,344 | 20,093 | -251 | 0.00 | 0.00 | +0.00 | sell |
| GEM Asset Management, LLC | 30,000 | 20,000 | -10,000 | 0.04 | 0.04 | +0.01 | sell |
| Marex Group plc | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 21,960 | 18,310 | -3,650 | 0.00 | 0.00 | +0.00 | sell |
| JGP Global Gestao de Recursos Ltda. | 17,346 | 17,346 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 15,300 | 17,300 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 15,893 | 15,893 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SALEM INVESTMENT COUNSELORS INC | 78,800 | 15,550 | -63,250 | 0.01 | 0.00 | -0.00 | sell |
| Lantern Wealth Advisors, LLC | 18,000 | 15,000 | -3,000 | 0.03 | 0.03 | -0.00 | sell |
| CITIGROUP INC | 4,337 | 14,456 | +10,119 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 18,750 | 14,319 | -4,431 | 0.00 | 0.00 | +0.00 | sell |
| HighTower Advisors, LLC | 21,486 | 14,121 | -7,365 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 14,254 | 13,491 | -763 | 0.00 | 0.00 | +0.00 | sell |
| J2 Capital Management Inc | 0 | 13,100 | +13,100 | 0.00 | 0.04 | +0.04 | buy |
| Pathstone Holdings, LLC | 20,863 | 12,811 | -8,052 | 0.00 | 0.00 | -0.00 | sell |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 12,600 | 12,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFG Investments, LLC | 12,500 | 12,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 11,322 | 12,468 | +1,146 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 13,238 | 12,309 | -929 | 0.04 | 0.02 | -0.01 | sell |
| Moloney Securities Asset Management, LLC | 14,400 | 12,000 | -2,400 | 0.00 | 0.01 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 9,929 | 11,530 | +1,601 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 13,443 | 11,146 | -2,297 | 0.00 | 0.00 | +0.00 | sell |
| MISSION WEALTH MANAGEMENT, LP | 10,651 | 10,651 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Janney Montgomery Scott LLC | 13,043 | 10,543 | -2,500 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 10,127 | +10,127 | 0.00 | 0.02 | +0.02 | buy |