| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Prosight Management, LP | 2,352,633 | 9,079,539 | +6,726,906 | 2.08 | 5.81 | +3.73 | buy |
| TANG CAPITAL MANAGEMENT LLC | 461,699 | 2,300,000 | +1,838,301 | 0.14 | 0.43 | +0.29 | buy |
| Opaleye Management Inc. | 200,000 | 800,000 | +600,000 | 0.14 | 0.35 | +0.21 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,061,356 | 2,533,635 | +472,279 | 0.02 | 0.02 | 0.00 | buy |
| Quadrature Capital Ltd | 13,929 | 59,617 | +45,688 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 161,620 | 195,500 | +33,880 | 0.11 | 0.11 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 308,567 | 340,267 | +31,700 | 48.86 | 6.38 | -42.48 | buy |
| TrueMark Investments, LLC | 109,957 | 134,414 | +24,457 | 0.11 | 0.11 | +0.00 | buy |
| Green Alpha Advisors, LLC | 24,709 | 48,515 | +23,806 | 0.06 | 0.10 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 34,546 | 56,674 | +22,128 | 0.01 | 0.02 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 17,779 | 22,598 | +4,819 | 0.07 | 0.11 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 1,092,169 | 1,096,575 | +4,406 | 0.00 | 0.00 | 0.00 | buy |
| Resolute Advisors LLC | 57,526 | 61,576 | +4,050 | 0.04 | 0.03 | -0.01 | buy |
| FIL Ltd | 119,973 | 123,879 | +3,906 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 27,185 | 27,678 | +493 | 0.04 | 0.03 | -0.01 | buy |
| SCOTIA CAPITAL INC. | 15,069 | 15,124 | +55 | 0.00 | 0.00 | -0.00 | buy |
| SEARLE & CO. | 15,000 | 13,900 | -1,100 | 0.01 | 0.01 | -0.00 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 88,410 | 83,937 | -4,473 | 0.03 | 0.03 | -0.01 | sell |
| PDT Partners, LLC | 238,188 | 64,304 | -173,884 | 0.07 | 0.01 | -0.05 | sell |
| BAILLIE GIFFORD & CO | 21,911,014 | 12,894,703 | -9,016,311 | 0.05 | 0.03 | -0.03 | sell |