| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 27,525,640 | 27,525,640 | 0 | 1.04 | 0.74 | -0.30 | hold |
| BAILLIE GIFFORD & CO | 21,911,014 | 12,894,703 | -9,016,311 | 0.05 | 0.03 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,624,185 | 10,624,185 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Prosight Management, LP | 2,352,633 | 9,079,539 | +6,726,906 | 2.08 | 5.99 | +3.90 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,598,626 | 4,590,103 | -8,523 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 4,180,768 | 4,180,768 | 0 | 0.25 | 0.20 | -0.05 | hold |
| ArrowMark Colorado Holdings LLC | 4,105,095 | 4,105,095 | 0 | 0.14 | 0.14 | -0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,728,603 | 2,946,703 | +1,218,100 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,061,356 | 2,533,635 | +472,279 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 461,699 | 2,300,000 | +1,838,301 | 0.14 | 0.43 | +0.29 | buy |
| FEDERATED HERMES, INC. | 2,726,016 | 2,282,696 | -443,320 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 1,764,800 | 2,177,600 | +412,800 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,473,210 | 1,499,640 | +26,430 | 0.00 | 0.00 | -0.00 | buy |
| Novo Holdings A/S | 1,126,915 | 1,126,915 | 0 | 0.18 | 0.15 | -0.03 | hold |
| LAZARD ASSET MANAGEMENT LLC | 1,092,169 | 1,096,575 | +4,406 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 922,214 | 922,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Opaleye Management Inc. | 200,000 | 800,000 | +600,000 | 0.14 | 0.35 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 450,690 | 753,887 | +303,197 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 552,130 | 589,653 | +37,523 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 545,533 | 545,533 | 0 | 0.44 | 0.36 | -0.08 | hold |
| D. E. Shaw & Co., Inc. | 466,565 | 420,240 | -46,325 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 408,874 | 407,384 | -1,490 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 334,264 | 355,747 | +21,483 | 0.00 | 0.00 | -0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 308,567 | 340,267 | +31,700 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 318,550 | 323,229 | +4,679 | 0.00 | 0.00 | -0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 311,890 | 311,890 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Walleye Capital LLC | 0 | 256,881 | +256,881 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 22,163 | 241,866 | +219,703 | 0.00 | 0.05 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 248,748 | 234,064 | -14,684 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 245,604 | 232,424 | -13,180 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 95,768 | 205,707 | +109,939 | 0.00 | 0.00 | +0.00 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 161,620 | 195,500 | +33,880 | 0.11 | 0.11 | +0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 63,000 | 191,150 | +128,150 | 0.01 | 0.01 | +0.01 | buy |
| TrueMark Investments, LLC | 109,957 | 134,414 | +24,457 | 0.11 | 0.11 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 129,904 | +129,904 | 0.00 | 0.00 | +0.00 | buy |
| FIL Ltd | 119,973 | 123,879 | +3,906 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 117,830 | 117,830 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EntryPoint Capital, LLC | 28,091 | 117,158 | +89,067 | 0.04 | 0.17 | +0.13 | buy |
| AMERICAN CENTURY COMPANIES INC | 117,216 | 117,126 | -90 | 0.00 | 0.00 | -0.00 | sell |
| ArchPoint Investors | 115,055 | 115,055 | 0 | 0.13 | 0.10 | -0.03 | hold |
| ADAR1 Capital Management, LLC | 0 | 114,981 | +114,981 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 314,866 | 113,653 | -201,213 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 154,772 | 105,952 | -48,820 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 106,477 | 104,254 | -2,223 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 87,000 | 87,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STANSBERRY ASSET MANAGEMENT, LLC | 88,410 | 83,937 | -4,473 | 0.03 | 0.03 | -0.01 | sell |
| GROUP ONE TRADING LLC | 18,975 | 74,984 | +56,009 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 102,377 | 74,814 | -27,563 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 69,900 | 69,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 39,095 | 65,097 | +26,002 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 238,188 | 64,304 | -173,884 | 0.07 | 0.01 | -0.05 | sell |
| SIMPLEX TRADING, LLC | 37,185 | 64,183 | +26,998 | 0.00 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 62,000 | 62,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Resolute Advisors LLC | 57,526 | 61,576 | +4,050 | 0.04 | 0.03 | -0.01 | buy |
| Quadrature Capital Ltd | 13,929 | 59,617 | +45,688 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 58,237 | +58,237 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 41,659 | 58,013 | +16,354 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 34,546 | 56,674 | +22,128 | 0.01 | 0.02 | +0.00 | buy |
| Cerity Partners LLC | 20,557 | 53,057 | +32,500 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 24,709 | 48,515 | +23,806 | 0.06 | 0.10 | +0.04 | buy |
| Stratos Wealth Advisors, LLC | 45,500 | 45,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 39,668 | 39,668 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 40,382 | 39,447 | -935 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 0 | 35,799 | +35,799 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 10,365 | 35,659 | +25,294 | 0.00 | 0.00 | +0.00 | buy |
| B. Riley Wealth Advisors, Inc. | 21,500 | 34,000 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 16,810 | 31,503 | +14,693 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,052 | 29,838 | +28,786 | 0.00 | 0.01 | +0.01 | buy |
| BRANDYWINE MANAGERS, LLC | 28,488 | 28,488 | 0 | 0.09 | 0.08 | -0.01 | hold |
| VIRTUS ADVISERS, LLC | 27,185 | 27,678 | +493 | 0.04 | 0.03 | -0.01 | buy |
| Lantern Wealth Advisors, LLC | 23,300 | 23,300 | 0 | 0.05 | 0.04 | -0.01 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 14,999 | 23,209 | +8,210 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 17,779 | 22,598 | +4,819 | 0.07 | 0.12 | +0.05 | buy |
| BARCLAYS PLC | 20,828 | 22,293 | +1,465 | 0.00 | 0.00 | -0.00 | buy |
| Clarkston Capital Partners, LLC | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 21,497 | 21,497 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GTS SECURITIES LLC | 18,355 | 21,479 | +3,124 | 0.00 | 0.00 | -0.00 | buy |
| Ballentine Partners, LLC | 0 | 20,732 | +20,732 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,787 | 19,593 | +6,806 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKET INC. | 18,165 | 17,665 | -500 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 18,152 | 17,412 | -740 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 15,012 | 16,499 | +1,487 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,780 | 15,983 | +5,203 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 24,168 | 15,705 | -8,463 | 0.00 | 0.00 | -0.00 | sell |
| SCOTIA CAPITAL INC. | 15,069 | 15,124 | +55 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,927 | 14,951 | +1,024 | 0.00 | 0.00 | -0.00 | buy |
| PFG Investments, LLC | 15,100 | 14,000 | -1,100 | 0.00 | 0.00 | -0.00 | sell |
| SEARLE & CO. | 15,000 | 13,900 | -1,100 | 0.01 | 0.01 | -0.00 | sell |
| Cetera Investment Advisers | 0 | 13,877 | +13,877 | 0.00 | 0.00 | +0.00 | buy |
| Kestra Advisory Services, LLC | 10,818 | 13,818 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 13,371 | +13,371 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 68,908 | 13,318 | -55,590 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 19,063 | 13,313 | -5,750 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 12,886 | +12,886 | 0.00 | 0.00 | +0.00 | buy |
| Integrity Financial Corp /WA | 12,050 | 12,050 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Baader Bank Aktiengesellschaft | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 10,685 | 11,902 | +1,217 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 10,200 | 11,750 | +1,550 | 0.00 | 0.00 | -0.00 | buy |
| NBC SECURITIES, INC. | 7,320 | 11,420 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |